Expression of gekΔCC.Scer\UAS under the control of Scer\GAL4Glass38-1 results in normal R cell axon targeting. No photoreceptor morphology defects are seen in third instar eye discs, although adult animals have rough eyes.
Expression of gekΔCC.Scer\UAS under the control of Scer\GAL4Glass38-1 in gekomb1080/Df(2R)e03819-f02302 mutant third instar larvae results in early termination of many R cell growth cones, with large clumps appearing in the optic stalk and the distal lamina.
Scer\GAL4elav-C155/gekΔCC.UAS partially rescues gekomb1080
Expression of gekΔCC.Scer\UAS in pupal stage R cells under the control of Scer\GAL4elav-C155 rescues the axon targeting phenotypes seen in gekomb1080 homozygous clones. 84% of axons extend correctly, 4% mistarget and 12% do not extend. Premature stopping of R1-R6 axons above the lamina plexus was not observed. However, approximately 18% of R cells exhibit morphological defects, with apical domains extending too far towards the center of the ommatidium or being located basally. 6% of all R cell bodies are below the plane of the ommatidium. All remaining R cells appear normal.
