FB2024_03 , released June 25, 2024
Allele: Dmel\Gyc76CRNAi.UAS.WIZ
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General Information
Symbol
Dmel\Gyc76CRNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0268059
Feature type
allele
Associated gene
Dmel\Gyc76C
Associated Insertion(s)
Carried in Construct
P{UAS-Gyc76C.RNAi.WIZ}
Also Known As
UAS-Gyc76C RNAi
Key Links
Transgenic product class
RNAi_reagent
(Overend et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Overend et al., 2012)
Mutagen
in vitro construct
(Overend et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Gyc76C.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 333bp Gyc76C fragment. The repeats are in tail-to-tail orientation and are separated by w intron sequences.

(Overend et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Gyc76C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Gyc76CdsRNA.UAS.WIZ under the control of Scer\GAL4Cg.PA show increased susceptibility (i.e. mortality) to infection with Staphylococcus saprophyticus bacteria. Larvae expressing Gyc76CdsRNA.UAS.WIZ under the control of Scer\GAL4c564 (together with Dicer-2, for more efficient RNAi) also exhibit increased susceptibility to infection with Staphylococcus saprophyticus bacteria.

      (Kanoh et al., 2021)

      Expression of Gyc76CdsRNA.UAS.WIZ under the control of Scer\GAL4Cg.PA leads to increased mortality upon infection by S. saprophyticus when compared to control adults.

      (Iwashita et al., 2020)

      Flies expressing Gyc76CdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4Uro.PT show normal survival in response to infection with E. coli.

      Flies expressing Gyc76CdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4Uro.PT show reduced survival under salt stress compared to controls.

      (Overend et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gyc76CRNAi.UAS.WIZ
      Gyc76CdsRNA.Scer\UAS.WIZ
      Gyc76CdsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (6)