FB2024_03 , released June 25, 2024
Allele: Dmel\Cdc37NIG.12019R
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General Information
Symbol
Dmel\Cdc37NIG.12019R
Species
D. melanogaster
Name
FlyBase ID
FBal0271079
Feature type
allele
Associated gene
Dmel\Cdc37
Associated Insertion(s)
Carried in Construct
P{NIG.12019R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.12019R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-12019R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      All larvae expressing Cdc37NIG.12019R under the control of Scer\GAL4A58 show defective epidermal wound closure; cells one to three rows distal to the wound margin fail to undergo the dramatic cell shape changes normally observed in controls, and instead retain a pentagonal or hexagonal cell shape, even 24-30 h after injury; epidermal cells remain small even 24h after injury. The size of epidermal cell nuclei is significantly decreased compared to controls and fails to increase upon wounding; the cell size also fails to increase upon wounding.

      (Lee et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Cdc37NIG.12019R, Scer\GAL4A58 has embryonic/larval epidermis | larval stage | conditional phenotype, suppressible by Dmoj\Cdc37UAS.cLa, Scer\GAL4A58

      (Lee et al., 2019)
      NOT suppressed by
      Statement
      Reference

      Cdc37NIG.12019R, Scer\GAL4A58 has embryonic/larval epidermis | larval stage | conditional phenotype, non-suppressible by JraUAS.cUa, Scer\GAL4A58

      (Lee et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdc37NIG.12019R
      cdc37-i12019
      (Lee et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)