FlyBase Allele Report: Dmel\mfrn[NIG.4963R]

General Information

Symbol

Dmel\mfrn^NIG.4963R

Species

D. melanogaster

Name

FlyBase ID

FBal0274459

Feature type

allele

Associated gene

Dmel\mfrn

Associated Insertion(s)

Carried in Construct

P{NIG.4963R}

Also Known As

dmfrn RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.4963R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-4963R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Friedreich ataxia

modeled by fh^RNAi.UAS.cLa

(Navarro et al., 2015)

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Wan et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive, with Scer\GAL4^Act5C.PU

(Navarro et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of mfrn^NIG.4963R under the control of Scer\GAL4^Act5C.PU causes lethality in under low iron conditions, whereas flies eclose at normal rates when reared on normal or iron-enriched food.

(Navarro et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is an enhancer of visible | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa

(Xue et al., 2022)

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is an enhancer of visible | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Tsf1^KK103815

(Xue et al., 2022)

NOT Enhancer of

Statement

Reference

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-enhancer of visible | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-enhancer of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

mfrn^NIG.4963R/Tsf1^KK103815, Scer\GAL4^Mhc.PU is a non-enhancer of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa/mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-enhancer of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

NOT Suppressor of

Statement

Reference

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-suppressor of visible | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-suppressor of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa/mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-suppressor of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

mfrn^NIG.4963R/Tsf1^KK103815, Scer\GAL4^Mhc.PU is a non-suppressor of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Phenotype Manifest In

Enhancer of

Statement

Reference

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is an enhancer of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa

(Xue et al., 2022)

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is an enhancer of adult thorax phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa

(Xue et al., 2022)

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is an enhancer of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Tsf1^KK103815

(Xue et al., 2022)

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is an enhancer of adult thorax phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Tsf1^KK103815

(Xue et al., 2022)

NOT Enhancer of

Statement

Reference

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-enhancer of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

NOT Suppressor of

Statement

Reference

mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-suppressor of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of mfrn^NIG.4963R suppresses the reduced survival seen when fh^{dsRNA.Scer\UAS.cLa} is expressed under the control of Scer\GAL4^Act5C.PU in response to 2.5mM iron treatment. The reduced survival seen in fh^{dsRNA.Scer\UAS.cLa}-expressing flies at 15mM iron treatment is not suppressed by mfrn^NIG.4963R.

(Navarro et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mfrn^NIG.4963R

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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