FB2024_03 , released June 25, 2024
Allele: Dmel\taraNIG.6889R
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General Information
Symbol
Dmel\taraNIG.6889R
Species
D. melanogaster
Name
FlyBase ID
FBal0275328
Feature type
allele
Associated gene
Dmel\tara
Associated Insertion(s)
Carried in Construct
P{NIG.6889R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.6889R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-6889R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neuronal co-expression of taraNIG.6889R and taraJF01421 under the control of either Scer\GAL4elav.PU or Scer\GAL4nSyb.PU results in a substantial reduction in daily sleep levels.

      Co-expression of taraNIG.6889R and taraJF01421 in cholinergic neurons under the control of Scer\GAL4ChAT.PU results in a reduction in sleep levels, but no phenotypes are seen when taraNIG.6889R and taraJF01421 are expressed using any of Scer\GAL4VGlut.PU, Scer\GAL4Gad1.PU, Scer\GAL4Tdc2.PU, Scer\GAL4c309, Scer\GAL4ey-OK107, Scer\GAL4104Y, Scer\GAL4Ilp2.PU, Scer\GAL4Dh44.PU, Scer\GAL4tim.PU or Scer\GAL4Pdf.PU.

      Co-expression of taraNIG.6889R and taraJF01421 in the pars lateralis under the control of either Scer\GAL4Crz.504.Δ311-249 results in a reduction in daily sleep levels.

      (Afonso et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4elav.PU, taraJF01421, taraNIG.6889R has abnormal sleep phenotype, enhanceable by CycAC8LR1/CycA[+]

      (Afonso et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of CycAC8LR1 enhances the sleep defects seen in flies co-expressing taraNIG.6889R and taraJF01421 under the control of Scer\GAL4elav.PU.

      (Afonso et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      taraNIG.6889R
      Name Synonyms
      Secondary FlyBase IDs
        References (3)