FB2024_03 , released June 25, 2024
Allele: Dmel\sevAct.hs2sev
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General Information
Symbol
Dmel\sevAct.hs2sev
Species
D. melanogaster
Name
FlyBase ID
FBal0276783
Feature type
allele
Associated gene
Dmel\sev
Associated Insertion(s)
Carried in Construct
P{sev-hs-sev.Act}
Key Links
Transgenic product class
gain_of_function_variant
(Mavromatakis and Tomlinson, 2012)
Mutagen
Nature of the Allele
Transgenic product class
gain_of_function_variant
(Mavromatakis and Tomlinson, 2012)
Mutagen
in vitro construct
(Mavromatakis and Tomlinson, 2012)
Progenitor genotype
Carried in construct
P{sev-hs-sev.Act}
Cytology
Description

A 1.2kb restriction fragment containing a copy of the sev enhancer guides the expression of activated sev sequence expressed from an Hsp70 promoter.

(Mavromatakis and Tomlinson, 2012)
Allele components
Component
Use(s)
Regulatory region(s)
sev
Encoded product / tool
sev
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sevAct.hs2sev mutant flies exhibit rough eyes that show the multiple R7 photoreceptors in tangential section.

      (Mavromatakis and Tomlinson, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      sevAct.hs2sev has eye phenotype, suppressible by R[+]/Rap1rvB3

      (Mavromatakis and Tomlinson, 2012)

      sevAct.hs2sev has photoreceptor cell R7 | increased number phenotype, suppressible by R[+]/Rap1rvB3

      (Mavromatakis and Tomlinson, 2012)

      sevAct.hs2sev has ommatidium phenotype, suppressible by R[+]/Rap1rvB3

      (Mavromatakis and Tomlinson, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Removal of one copy of R (sevAct.hs2sev/+; RrvB3/+) results in a decrease the eye roughening and a significant reduction in the multiple R7 phenotype (from 90% of the ommatidia containing multiple R7 cells to 48%).

      (Mavromatakis and Tomlinson, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sevAct.hs2sev
      Name Synonyms
      Secondary FlyBase IDs
        References (2)