FlyBase Allele Report: Dmel\XNP[RNAi.UAS.Sym]

General Information

Symbol

Dmel\XNP^RNAi.UAS.Sym

Species

D. melanogaster

Name

FlyBase ID

FBal0278261

Feature type

allele

Associated gene

Dmel\XNP

Associated Insertion(s)

Carried in Construct

P{UAS-XNP.RNAi.Sym}

Key Links

Transgenic product class

RNAi_reagent

(Valadez-Graham et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Valadez-Graham et al., 2012)

Mutagen

in vitro construct

(Valadez-Graham et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-XNP.RNAi.Sym}

Cytology

Description

UAS regulatory sequences drive expression of a dsRNA corresponding to bases 3765-4087 of XNP.

(Valadez-Graham et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

XNP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

XNP^RNAi.UAS.Sym, Scer\GAL4^pnr-MD237 is a suppressor | partially of visible phenotype of Dref^GD11784, Scer\GAL4^pnr-MD237

(Valadez-Graham et al., 2012)

Scer\GAL4^pnr-MD237/XNP^RNAi.UAS.Sym is a suppressor | partially of partially lethal - majority die phenotype of pnr^MD237/pnr^VX6

(Valadez-Graham et al., 2012)

Scer\GAL4^pnr-MD237/XNP^RNAi.UAS.Sym is a suppressor of lethal | recessive phenotype of pnr^MD237

(Valadez-Graham et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

XNP^RNAi.UAS.Sym, Scer\GAL4^pnr-MD237 is a suppressor of adult thorax | dorsal phenotype of Dref^GD11784, Scer\GAL4^pnr-MD237

(Valadez-Graham et al., 2012)

XNP^RNAi.UAS.Sym, Scer\GAL4^pnr-MD237 is a suppressor | partially of macrochaeta phenotype of Dref^GD11784, Scer\GAL4^pnr-MD237

(Valadez-Graham et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of XNP^{dsRNA.Scer\UAS.Sym} under the control of Scer\GAL4^pnr-MD237 partially rescues the lethality of pnr^VX6/pnr^MD237 such that 33% of the animals survive.

Expression of two copies of XNP^{dsRNA.Scer\UAS.Sym} under the control of Scer\GAL4^pnr-MD237 partially rescues the lethality of pnr^MD237 homozygotes such that 32% of the animals survive.

Co-expression of XNP^{dsRNA.Scer\UAS.Sym} completely suppresses the thoracic cleft phenotype seen in flies expressing Dref^GD11784 under the control of Scer\GAL4^pnr-MD237 and the penetrance of the loss of thoracic macrochaetae phenotype is reduced to 65%.

(Valadez-Graham et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

XNP^RNAi.UAS.Sym

XNP^{dsRNA.Scer\UAS.Sym}

XNP^{dsRNA.UAS.Sym}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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