FB2024_03 , released June 25, 2024
Allele: Dmel\Pink1HMS01707
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General Information
Symbol
Dmel\Pink1HMS01707
Species
D. melanogaster
Name
FlyBase ID
FBal0278825
Feature type
allele
Associated gene
Dmel\Pink1
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01707}
Also Known As
PINK1 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS01707}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01707
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 6
      CEA
      (Liu et al., 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease 6
      is ameliorated by Chchd28-8
      (Liu et al., 2020)
      ameliorates  amyotrophic lateral sclerosis type 10
      modeled by Hsap\TARDBPUAS.cDa
      (Sun et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The eyes of adults expressing Pink1HMS01707 under the control of Scer\GAL4GMR.PF show a progressive loss of rhabdomeres (more frequent at day 30 than at day 2).

      (Liu et al., 2020)

      Adults expressing Pink1HMS01707 under the control of Scer\GAL4Act5C.PI or Scer\GAL4ple.PF show a progressive decline in climbing activity, and a progressive decrease in DA neuron number (PPL1, PPL2, PPM1/2 and PPM3 clusters); DA neurons also show decreased abundance of mitochondria.

      (Pirooznia et al., 2020)

      Females heterozygous for Pink1HMS01707 and Scer\GAL4mat.αTub67C.T:Hsim\VP16 crossed to Pink1HMS01707 males results in: 85% hatching; non-maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Pink1HMS01707, Scer\GAL4GMR.PF has rhabdomere | adult stage phenotype, enhanceable by Chchd28-8

      (Liu et al., 2020)
      Suppressed by
      Enhancer of
      NOT Enhancer of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pink1HMS01707
      Name Synonyms
      Secondary FlyBase IDs
        References (11)