FB2024_02 , released April 23, 2024
Allele: Dmel\mAcon11
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General Information
Symbol
Dmel\mAcon11
Species
D. melanogaster
Name
FlyBase ID
FBal0284597
Feature type
allele
Associated gene
Dmel\mAcon1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Esposito et al., 2013)
Progenitor genotype
Cytology
Description

Nonsense mutation in exon 2.

(Esposito et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Esposito et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      mAcon11/Acon[+] is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Esposito et al., 2013)

      mAcon11, Drp1+t9.4, Acon[+] is a suppressor | partially of abnormal flight phenotype of Pink1B9

      (Esposito et al., 2013)
      NOT Suppressor of
      Statement
      Reference

      mAcon11/Acon[+] is a non-suppressor of abnormal flight phenotype of parkΔ21/park1

      (Esposito et al., 2013)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      mAcon11/Acon[+] is a suppressor | partially of mitochondrion phenotype of Pink1B9

      (Esposito et al., 2013)

      mAcon11/Acon[+] is a suppressor | partially of mitochondrion phenotype of ND-19GD16787, Scer\GAL4ple.PF

      (Esposito et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mitochondrial morphology defects seen in Pink1B9 adult flight muscles and dopaminergic neurons are significantly suppressed by Acon1/+. The flight defects of Pink1B9 adults are also significantly rescued.

      Acon1/+ partially suppresses the defects in mitochondria morphology seen in the dopaminergic neurons of animals NDUFA8GD16787 under the control of Scer\GAL4ple.PF.

      The mitochondria morphological defects seen in park1/parkΔ21 adults are not rescued by Acon1/+.

      Pink1B9 ; Acon1/+ ; Drp1+t9.4/+ animals show increased flight ability compared to either Pink1B9 ; Acon1/+ or Pink1B9 ; Drp1+t9.4/+ animals.

      (Esposito et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Acon1
      acon1
      (Esposito et al., 2013)
      mAcon11
      Name Synonyms
      Secondary FlyBase IDs
        References (1)