FB2024_04 , released June 25, 2024
Allele: Dmel\unc-104UAS.mCherry
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General Information
Symbol
Dmel\unc-104UAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0294159
Feature type
allele
Associated gene
Dmel\unc-104
Associated Insertion(s)
Carried in Construct
P{UAS-unc-104.mCherry}
Key Links
Transgenic product class
wild_type
(Kern et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kern et al., 2013)
Mutagen
in vitro construct
(Kern et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-unc-104.mCherry}
Cytology
Description

UAS regulates expression of unc-104 tagged with mCherry.

(Kern et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
unc-104
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/unc-104UAS.mCherry rescues unc-104bris

      (Zhang et al., 2017)

      Scer\GAL4elav-C155/unc-104UAS.mCherry rescues unc-104bris/unc-104d11204

      (Kern et al., 2013)
      Partially rescues

      Scer\GAL4elav-C155/unc-104UAS.mCherry partially rescues unc-104bris/unc-104d11204

      (Kern et al., 2013)
      Fails to rescue

      Scer\GAL4how-24B/unc-104UAS.mCherry fails to rescue unc-104bris

      (Zhang et al., 2017)
      Comments

      Expression of unc-104Scer\UAS.T:Disc\RFP-mCherry under the control of Scer\GAL4elav.PU rescues the impaired synaptic transmission as well as the defects in the ultrastructure of the subsynaptic reticulum membrane in unc-104bris mutant larval neuromuscular junctions (NMJs). Expression driven by Scer\GAL4how-24B fails to improve the disrupted subsynaptic reticulum membrane morphology in the mutant NMJs.

      (Zhang et al., 2017)

      Scer\GAL4elav-C155-mediated expression of unc-104Scer\UAS.T:Disc\RFP-mCherry rescues the lethality, impaired locomotion, and defective body posture of unc-104bris/unc-104d11204 larvae. The defective apposition of active zones and post-synaptic densities of unc-104bris/unc-104d11204 larvae is partially rescued. The neuromuscular junction morphology defects of unc-104bris/unc-104d11204 larvae are rescued by Scer\GAL4elav-C155-mediated, but not Scer\GAL4how-24B-mediated expression of unc-104Scer\UAS.T:Disc\RFP-mCherry.

      (Kern et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Obtained from Thomas Schwarz.

      (Kern et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      unc-104Scer\UAS.T:Disc\RFP-mCherry
      unc-104UAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (2)