Hsap\MFN2UAS.Tag:MYC, MarfGD11094, Scer\GAL4elav.PLu has partially lethal phenotype, non-suppressible by Hsap\MFN1UAS.Tag:MYC, Scer\GAL4elav.PLu
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4elav.PLu is a suppressor | partially of lethal - all die during pupal stage phenotype of MarfGD11094, Scer\GAL4elav.PLu
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4Mef2.PR is a suppressor | partially of partially lethal - majority die phenotype of MarfGD11094, Scer\GAL4Mef2.PR
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4Mhc.PU is a suppressor of abnormal locomotor behavior | adult stage phenotype of MarfGD11094, Scer\GAL4Mhc.PU
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4elav.PLu is a suppressor of endoplasmic reticulum | larval stage phenotype of MarfGD11094, Scer\GAL4elav.PLu
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4Mef2.PR is a suppressor of sarcoplasmic reticulum | larval stage phenotype of MarfGD11094, Scer\GAL4Mef2.PR
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4elav.PLu is a non-suppressor of mitochondrion | larval stage phenotype of MarfGD11094, Scer\GAL4elav.PLu
Hsap\MFN2UAS.Tag:MYC, Scer\GAL4Mef2.PR is a non-suppressor of mitochondrion | larval stage phenotype of MarfGD11094, Scer\GAL4Mef2.PR
Expression of Hsap\MFN2Scer\UAS.T:Hsap\MYC in a Scer\GAL4elav.PLu MarfGD11094 background allows survival to adulthood of ~50% of individuals. Neuronal cell body mitochondria remain fragmented but ER morphology is restored.
Expression of Hsap\MFN2Scer\UAS.T:Hsap\MYC in a Scer\GAL4Mef2.PR MarfGD11094 background allows greater survival to adulthood, and ER, but not mitochondrial, morphology is restored.
Co-expression of Hsap\MFN2Scer\UAS.T:Hsap\MYC rescues the impaired climbing ability of Scer\GAL4Mhc.PU MarfGD11094 flies.