FB2024_03 , released June 25, 2024
Allele: Dmel\TkR86CΔF28
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General Information
Symbol
Dmel\TkR86CΔF28
Species
D. melanogaster
Name
FlyBase ID
FBal0295797
Feature type
allele
Associated gene
Dmel\TkR86C
Associated Insertion(s)
P{?SUPor-P}TkR86CΔF28
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Asahina et al., 2014)
Progenitor genotype
P{SUPor-P}TkR86CKG07724
(Asahina et al., 2014)
Associated Insertion(s)
P{?SUPor-P}TkR86CΔF28
Cytology
Description

Imprecise excision of the P{SUPor-P} element in P{SUPor-P}TkR86CKG07724 has generated a 1,020bp deletion that removes most of the first exon of TkR86C, including the start codon and the first 60 amino acids which contain the signal peptide and most of the N-terminal extracellular domain ( 3R:6 ,576,803-6,575,782, release 5 coordinates). 678bp of the P{SUPor-P} element is still inserted at the chromosome break point.

(Asahina et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:10,750,060..10,751,081 [-]
Comment:

1020 bp deletion in TkR86C resulting from the imprecise excsion of P{SUPor-P}TkR86CKG07724 removes most of the first exon of TkR86C. 678 bp of the P element remain.

(Asahina et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous TkR86CΔF28 does not diminish baseline aggression in single-housed flies compared to controls.

      (Asahina et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      TkR86CΔF28 is a suppressor of abnormal behavior | adult stage | heat sensitive phenotype of Scer\GAL4Tk, TrpA1UAS.(B).cKa

      (Asahina et al., 2014)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous TkR86CΔF28 significantly suppresses the aggression-promoting effect of activating neurons labeled with Scer\GAL4Tk (either the P{Tk-GAL4.TH}5Fa or P{Tk-GAL4.TH}3Ma insertion) through expression of thermosensitive TrpA1Scer\UAS.(B).cKa. This suppression is partially reversed upon expression of TkR86C+tCH322-17N40.

      TkR86CΔF28, TkR99DMB09356 double mutants show a strong reduction in baseline and induced aggression compared to controls.

      (Asahina et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      TkR86CΔF28
      Name Synonyms
      Secondary FlyBase IDs
        References (1)