Under constant darkness conditions, most flies expressing dom^HMC04203 under the control of either Scer\GAL4^P2.4.Pdf alone, Scer\GAL4^tim.PE alone, or Scer\GAL4^tim.PE in combination of Scer\GAL80^Pdf.PS, lose circadian rhythmicity and periods become longer, as compared to controls. Longer periods are also observed when the Scer\GAL4^tim.PE, Scer\GAL80^Pdf.PS-regulated expression is restricted to adulthood, but not to development (by using Gal80[ts] for the temporal control of expression).

The expression of dom^HMC04203 under the control of Scer\GAL4^tim.PE alone has no effect on amplitude of rhythms or morning anticipation under LD cycles.

The expression of dom^HMC04203 under the control of either Scer\GAL4^tim.PE or Scer\GAL4^P2.4.Pdf does not lead to obvious defects in the brain structure and does not affect the number of lLNvs neurons or their dorsal projections. Expression under the control of Scer\GAL4^tim.PE also does not affect the number of sLNv neurons.

Expression of dom^HMC04203 under the control of Scer\GAL4^Act5C.PI results in pupal lethality.

Expression of dom^HMC04203 under the control of Scer\GAL4^bbg-C96 results in a minority of flies exhibiting wing nicks or defective wing margins, in contrast to controls.

Expression of dom^HMC04203 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{otu.T:Hsim\VP16} causes significantly decreased female fertility, with germline development in the germarium appearing normal, but later stage egg chambers appearing defective, as compared to controls.

Expression of dom^HMC04203 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} does not affect the development of the germarium or ovariole, but results in a significant proportion of eggs showing the 'dumpless' egg phenotype, as shown by defective late stage egg chambers with short eggs and non-fragmented nurse cells, and a significant reduction in egg-laying, as compared to controls.

Expression of dom^HMC04203 under the control of Scer\GAL4^tj.PU or Scer\GAL4^C587 leads to severe packaging defects during oogenesis, ranging from two cysts in a single egg chamber to complete ovariole fusions; many germaria show additional stalk-like structures without germline cysts, and egg laying is nearly completely abolished, as compared to controls.