FlyBase Allele Report: Dmel\cnk[CCT.hs.sev]

General Information

Symbol

Dmel\cnk^CCT.hs.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0304112

Feature type

allele

Associated gene

Dmel\cnk

Associated Insertion(s)

Carried in Construct

P{sE-cnk.CCT}

Key Links

Transgenic product class

inframe_deletion

(Baril et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Baril et al., 2014)

Mutagen

in vitro construct

(Baril et al., 2014)

Progenitor genotype

Carried in construct

P{sE-cnk.CCT}

Cytology

Description

sev enhancer sequences and a heat shock promoter drive expression of the C-terminal portion (amino acids 382-1557) of cnk.

(Baril et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

cnk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Baril et al., 2014)

Phenotype Manifest In

eye

(Baril et al., 2014)

eye photoreceptor cell

(Baril et al., 2014)

Detailed Description

Statement

Reference

Flies expressing cnk^CCT.hs.sev show loss of photoreceptor cells, which results in a mild rough eye phenotype.

(Baril et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

cnk^CCT.hs.sev has visible phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-322

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-696

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Btk29A[+]/Btk^E-306

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Btk^E-1152/Btk29A[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by swm^E-876/swm[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-174

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by swm^E-1154/swm[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Prp19[+]/Prp19^E-162

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Prp19[+]/Prp19^E-40

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Prp19[+]/Prp19^E-1036

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by R[+]/Rap1^E-814

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by R[+]/Rap1^E-299

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by R[+]/Rap1^E-173

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by R[+]/Rap1^E-831

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Bre1[+]/Bre1^E-243

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-1102

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Bre1^E-534/Bre1[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by cno^E-1103/cno[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by cno^E-197/cno[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Nsf2^E-293/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Nsf2^E-617/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Nsf2^E-723/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by Nsf2^E-865/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by R[+]/Rap1^E-722

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-185

(Baril et al., 2014)

cnk^CCT.hs.sev has visible phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-323

(Baril et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

cnk^CCT.hs.sev has eye phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-174

(Baril et al., 2014)

cnk^CCT.hs.sev has eye photoreceptor cell phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-174

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-696

(Baril et al., 2014)

cnk^CCT.hs.sev has eye photoreceptor cell phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-696

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Btk29A[+]/Btk^E-306

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Btk^E-1152/Btk29A[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by swm^E-876/swm[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by swm^E-1154/swm[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Prp19[+]/Prp19^E-162

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Prp19[+]/Prp19^E-40

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Prp19[+]/Prp19^E-1036

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by R[+]/Rap1^E-814

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-1102

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by R[+]/Rap1^E-299

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by R[+]/Rap1^E-173

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by R[+]/Rap1^E-831

(Baril et al., 2014)

cnk^CCT.hs.sev has eye photoreceptor cell phenotype, enhanceable by R[+]/Rap1^E-831

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Bre1[+]/Bre1^E-243

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Bre1^E-534/Bre1[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by cno^E-1103/cno[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by cno^E-197/cno[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Nsf2^E-293/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Nsf2^E-617/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Nsf2^E-723/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-185

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by Nsf2^E-865/Nsf2[+]

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by R[+]/Rap1^E-722

(Baril et al., 2014)

cnk^CCT.hs.sev has eye photoreceptor cell phenotype, enhanceable by R[+]/Rap1^E-722

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-323

(Baril et al., 2014)

cnk^CCT.hs.sev has eye phenotype, enhanceable by PDZ-GEF[+]/PDZ-GEF^E-322

(Baril et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype seen in flies expressing cnk^CCT.hs.sev is dominantly enhanced by PDZ-GEF^E-1102, PDZ-GEF^E-185, PDZ-GEF^E-323, PDZ-GEF^E-322, Btk29A^E-306, Btk29A^E-1152, swm^E-876, swm^E-1154, Prp19^E-162, Prp19^E-40, Prp19^E-1036, R^E-814, R^E-299, R^E-173, Bre1^E-243, Bre1^E-534, cno^E-1103, cno^E-197, Nsf2^E-293, Nsf2^E-617, Nsf2^E-723 and Nsf2^E-865.

The rough eye phenotype seen in flies expressing cnk^CCT.hs.sev is dominantly enhanced by PDZ-GEF^E-174, PDZ-GEF^E-696, R^E-722 and R^E-831. In addition, the double mutant flies show an increased loss of photoreceptor cells compared to cnk^CCT.hs.sev single mutants.

(Baril et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cnk^CCT.hs.sev

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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