semang, sag, EK2-3
signaling protein - a critical molecule functioning downstream of Alk - mutational loss genocopies the lack of visceral muscle founder cell specification of Alk and jeb mutants - interacts with Steppke as part of a larger signaling scaffold coordinating receptor tyrosine kinase-dependent MAPK activation
Please see the JBrowse view of Dmel\cnk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
5.420 (longest cDNA)
1557 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cnk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
cnk protein localization was assayed with an epitope tagged version of cnk using the sev enhancer system. Pi3K68D protein localizes to the apical portion of sev-expressing cells where adherens junctions are found. In S2 cells it is found in the cytoplasm and also in the membrane at points of cell-cellcontact.
JBrowse - Visual display of RNA-Seq signals
View Dmel\cnk in JBrowse2-82
2-86.2
Mapped relative to the P{lacW} insertions in l(2)k07110k07110 and l(2)k14517k14517.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene.
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
2 alleles of cnk been recovered in a screen for mutations with mutant phenotypes in clones in the wing.
sag is required for R1/R6/R7 development in the eye.
The N-terminal portion of the cnk protein strongly cooperates with Ras85D, whereas the C-terminal portion efficiently blocks Ras85D (Ras) and phl (Raf) signalling when overexpressed in the eye. Two domains in the N-terminal portion of cnk are critical for cooperation with Ras85D. cnk functions in more than one pathway downstream of Ras85D. The C-terminal portion of cnk regulates phl, a component of rl (MAPK) signalling while the N-terminal portion of cnk is involved in a rl-independent pathway.
sag functions in several receptor tyrosine kinase-mediated processes.
Identified via an extragenic revertant of the Src42A mutant phenotype.
Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.
Mutant retinas lack the normal complement of photoreceptor neurons and cone cells. sag mutation only affects those cells derived from the second mitotic wave during retinal development. BrdU staining revealed that the number of mitotic cells in the second mitotic wave is reduced, but not eliminated. The first mitotic wave appears normal in the mutant.
Source for merge of: cnk anon-WO0140519.129 anon-WO0257455.27
Source for merge of: cnk sag
Source for merge of cnk anon-WO0140519.129 anon-WO0257455.27 was sequence comparison ( date:051113 ).
The gene is named "semang" (meaning "colour blind" in Chinese) because mutations affect the development of a subset of photoreceptors in the eye.
"semang" means "colour-blind" in Chinese.
