FB2024_03 , released June 25, 2024
Allele: Dmel\rheaB7
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General Information
Symbol
Dmel\rheaB7
Species
D. melanogaster
Name
FlyBase ID
FBal0304169
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
Also Known As
talin865
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Klapholz et al., 2015)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q865term.

(Klapholz and Brown, 2015.5.28)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,565,144..8,565,144 [+]
Nucleotide change:

C8565144T

Reported nucleotide change:

C?T

Amino acid change:

Q865term | rhea-PB; Q865term | rhea-PC; Q865term | rhea-PD; Q865term | rhea-PE; Q865term | rhea-PF; Q844term | rhea-PG; Q865term | rhea-PH

Reported amino acid change:

Q865term

Comment:

Reported as GAT CAG C>TAA CAG GAT mutation which maps to Q865 in the reference sequence, rather than Q866 as reported.

(Klapholz and Brown, 2015.5.28, Klapholz et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the wing result in wing blisters in more than 95% of wings.

      (Klapholz et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      rheaB7 homozygosity leads to a strong reduction in the number of ectopic VincCO.Scer\UAS.P\T.T:Equa\eqFP578-TagRFP-positive cytoplasmic protein aggregates formed in follicle cell clones upon Scer\GAL4Act5C.PU-driven expression.

      (Maartens et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rheaB7
      (Klapholz and Brown, 2015.5.28)
      talin865
      (Maartens et al., 2016, Klapholz et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)