FB2024_03 , released June 25, 2024
Allele: Dmel\uspUAS.cUa
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General Information
Symbol
Dmel\uspUAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0305272
Feature type
allele
Associated gene
Dmel\usp
Associated Insertion(s)
Carried in Construct
P{UAS-usp.U}
Key Links
Transgenic product class
wild_type
(Koyama et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Koyama et al., 2014)
Mutagen
in vitro construct
(Koyama et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-usp.U}
Cytology
Description

UAS regulatory sequences drive expression of usp.

(Koyama et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
usp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of uspScer\UAS.cUa under the control of Scer\GAL4phm.PO does not alter the timing of the 'critical weight' ecdysone peak compared to controls in response to starvation. Body size at critical weight is also similar to controls.

      Expression of uspScer\UAS.cUa under the control of Scer\GAL4phm.PO in starved larvae results in pharate adults with an increased body size compared to controls.

      (Koyama et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Statement
      Reference

      uspUAS.cUa/Scer\GAL4phtm.PO is an enhancer of increased body size | pharate adult stage | nutrition conditional phenotype of Scer\GAL4phtm.PO, foxoUAS.cKc

      (Koyama et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of uspScer\UAS.cUa enhances the delay in 'critical weight' ecdysone peak in response to starvation seen when foxoScer\UAS.cKc is expressed under the control of Scer\GAL4phm.PO. The increase in larval body size at critical weight is also enhanced.

      Co-expression of uspScer\UAS.cUa and foxoScer\UAS.cKc under the control of Scer\GAL4phm.PO enhances the increase in pharate adult body size seen following larval starvation compared with either transgene alone.

      Expressing foxoNK.Scer\UAS and uspScer\UAS.cUa under the control of Scer\GAL4phm.PO in foxoΔ94/Df(3R)Exel8159 mutant larvae does not alter the age and size of the 'critical weight' ecdysone peak, nor does it alter final body size when compared to overexpressing foxoNK.Scer\UAS alone.

      (Koyama et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The authors obtained this line from Michael O'Connor.

      (Koyama et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      uspScer\UAS.cUa
      uspUAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)