FlyBase Allele Report: Dmel\Apc2[UAS.cUa]

General Information

Symbol

Dmel\Apc2^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0305293

Feature type

allele

Associated gene

Dmel\Apc2

Associated Insertion(s)

Carried in Construct

P{UAS-Apc2.U}

Also Known As

UAS-Apc2

Key Links

Transgenic product class

wild_type

(Zhang et al., 2015)

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Transgenic product class

wild_type

(Zhang et al., 2015)

Mutagen

in vitro construct - regulatory fusion

(Zhang et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-Apc2.U}

Cytology

Description

UAS regulatory sequences drive expression of Apc2.

(Zhang et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Apc2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Apc2^Scer\UAS.cUa alone under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} has no obvious effect on the germline stem cell population in adult testes, as compared to controls.

(Liu et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Apc2^UAS.cUa is a suppressor | partially of decreased cell number | germline clone | adult stage phenotype of Mgtor^k03905

(Liu et al., 2015)

Apc2^UAS.cUa, Scer\GAL4^GMR.PF is a suppressor of abnormal size phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

Apc2^UAS.cUa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

Apc2^UAS.cUa, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

NOT Suppressor of

Statement

Reference

Apc2^UAS.cUa, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of decreased cell number | adult stage phenotype of Mgtor^GD13871, Scer\GAL4^{VP16.nanos.UTR}

(Liu et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Apc2^UAS.cUa is a suppressor | partially of male germline stem cell | adult stage phenotype of Mgtor^k03905

(Liu et al., 2015)

Apc2^UAS.cUa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

NOT Suppressor of

Statement

Reference

Apc2^UAS.cUa, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of testis | adult stage phenotype of Mgtor^GD13871, Scer\GAL4^{VP16.nanos.UTR}

(Liu et al., 2015)

Apc2^UAS.cUa, Scer\GAL4^{VP16.nanos.UTR} is a non-suppressor of male germline stem cell | adult stage phenotype of Mgtor^GD13871, Scer\GAL4^{VP16.nanos.UTR}

(Liu et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Apc2^Scer\UAS.cUa under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} does not suppress the decrease in germline stem cell numbers present in the testes of adults expressing Mtor^GD13871 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

Expression of Apc2^Scer\UAS.cUa under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} partially rescues the decreased number of germline stem cells in homozygous Mtor^k03905 within mosaic testes, as compared to control clones in control testes.

(Liu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Co-expression of Apc2^Scer\UAS.cUa significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU.

(Dupont et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Apc2^Scer\UAS.cUa

Apc2^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (3)

Report Sections

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