FB2024_02 , released April 23, 2024
Allele: Dmel\Hto-BLYBLY
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General Information
Symbol
Dmel\Hto-BLYBLY
Species
D. melanogaster
Name
FlyBase ID
FBal0317101
Feature type
allele
Associated gene
Hto-BLY
Associated Insertion(s)
Mi{Hto-WP}Hto-BLYBLY
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
minos activity
(Javeed et al., 2015)
Progenitor genotype
Associated Insertion(s)
Mi{Hto-WP}Hto-BLYBLY
Cytology
Description

Insertion of a Mi{Hto-WP} element upstream of Scr ( 3R:6 ,854,635 (-) -Release 6). The hostile takeover (hto) exon in the Mi{Hto-WP} element, which contains a T:Zzzz\FLAG tag and the mCherry form of Disc\RFP and usually splices to the next exon and tagging it, is out of frame with the Scr coding region so no Scr fusion protein is made.

(Javeed et al., 2015)
Allele components
Component
Use(s)
Inserted element
Mi{Hto-WP}
Regulatory region(s)
UAS
Tagged with
mCherry
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hto-BLYBLY under the control of Scer\GAL4ey.PU results in strong deformation of the head. The eyes are smaller, set back posteriorly, and bulging out laterally. The aristae are often curled instead of flat.

      No obvious wing defects are observed when Hto-BLYBLY is expressed under the control of Scer\GAL4Bx-MS1096.

      Eyes of flies expressing Hto-BLYBLY under the control of Scer\GAL4GMR.PU are normal.

      (Javeed et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Hto-BLYBLY, Scer\GAL4ey.PU has visible phenotype, non-suppressible by ScrJF03091, Scer\GAL4ey.PU

      (Javeed et al., 2015)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Hto-BLYBLY, Scer\GAL4ey.PU has head phenotype, non-suppressible by ScrJF03091, Scer\GAL4ey.PU

      (Javeed et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ScrJF03091 does not suppress the head deformation phenotypes seen when Hto-BLYBLY is expressed under the control of Scer\GAL4ey.PU.

      (Javeed et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hto-BLYBLY
      Name Synonyms
      Secondary FlyBase IDs
        References (1)