FlyBase Allele Report: Dmel\YME1L[del]

General Information

Symbol

Dmel\YME1L^del

Species

D. melanogaster

Name

FlyBase ID

FBal0322815

Feature type

allele

Associated gene

Dmel\YME1L

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

P{SUPor-P}YME1L^KG01861

(Qi et al., 2016)

Cytology

Description

2kb deletion which removes the majority of the YME1L coding region. Generated by imprecise excision of the progenitor P{SUPor-P}YME1L^KG01861 insertion.

(Qi et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | progressive

(Qi et al., 2016)

abnormal neuroanatomy | progressive

(Qi et al., 2016)

bang sensitive | progressive

(Qi et al., 2016)

male sterile

(Qi et al., 2016)

short lived | rescuable maternal effect

(Qi et al., 2016)

viable

(Qi et al., 2016)

Phenotype Manifest In

eye photoreceptor cell | progressive

(Qi et al., 2016)

indirect flight muscle cell | progressive

(Qi et al., 2016)

mitochondrion | progressive

(Qi et al., 2016)

rhabdomere | progressive

(Qi et al., 2016)

Detailed Description

Statement

Reference

Homozygotes (zygotically mutant) have a markedly reduced lifespan compared to controls, which is reduced even further if they are also derived from homozygous females.

Young homozygous flies appear similar to controls in a climbing test and bang sensitivity assay.

Homozygous adults show a number of age-dependent phenotypes, including defects in climbing ability, bang sensitivity and neurodegeneration of photoreceptor neurons (shown by progressive loss of rhabdomeres).

Homozygous adults show mitochondrial defects in the indirect flight muscles: the cristae are misoriented and are often loosely packed. Swollen mitochondria are also seen. These defects become more severe as the flies age and in addition, the mitochondria in aged flies (3 weeks old) contain electron-dense structures.

Apoptotic cell death is seen in the indirect flight muscles and in the photoreceptors of aged homozygous flies.

(Qi et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Sod1^UAS.cAa/Scer\GAL4^da.PU

(Qi et al., 2016)

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Scer\GAL4^da.PU/Sod2^UAS.cMa

(Qi et al., 2016)

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Scer\GAL4^da.PU/Dark^RNAi.UAS.cLa

(Qi et al., 2016)

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Dronc^HMS00758/Scer\GAL4^da.PU

(Qi et al., 2016)

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Scer\GAL4^da.PU/HtrA2^HM05030

(Qi et al., 2016)

YME1L^del has abnormal locomotor behavior | progressive phenotype, suppressible | partially by Sod1^UAS.cAa/Scer\GAL4^da.PU

(Qi et al., 2016)

YME1L^del has abnormal locomotor behavior | progressive phenotype, suppressible | partially by Scer\GAL4^da.PU/Sod2^UAS.cMa

(Qi et al., 2016)

YME1L^del has short lived phenotype, suppressible by Sod1^UAS.cAa/Scer\GAL4^da.PU

(Qi et al., 2016)

YME1L^del has short lived phenotype, suppressible by Scer\GAL4^da.PU/Sod2^UAS.cMa

(Qi et al., 2016)

YME1L^del has bang sensitive | progressive phenotype, suppressible by Scer\GAL4^da.PU/Hsap\YME1L1^UAS.GFP

(Qi et al., 2016)

YME1L^del has abnormal locomotor behavior | progressive phenotype, suppressible by Scer\GAL4^da.PU/Hsap\YME1L1^UAS.GFP

(Qi et al., 2016)

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Scer\GAL4^da.PU/Hsap\YME1L1^UAS.GFP

(Qi et al., 2016)

YME1L^del has abnormal neuroanatomy | progressive phenotype, suppressible by Diap1^GMR.PH

(Qi et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

YME1L^del has rhabdomere | progressive phenotype, suppressible by Diap1^GMR.PH

(Qi et al., 2016)

YME1L^del has rhabdomere | progressive phenotype, suppressible by Sod1^UAS.cAa/Scer\GAL4^da.PU

(Qi et al., 2016)

YME1L^del has rhabdomere | progressive phenotype, suppressible by Scer\GAL4^da.PU/Sod2^UAS.cMa

(Qi et al., 2016)

YME1L^del has rhabdomere | progressive phenotype, suppressible by Scer\GAL4^da.PU/Dark^RNAi.UAS.cLa

(Qi et al., 2016)

YME1L^del has rhabdomere | progressive phenotype, suppressible by Dronc^HMS00758/Scer\GAL4^da.PU

(Qi et al., 2016)

YME1L^del has rhabdomere | progressive phenotype, suppressible by Scer\GAL4^da.PU/HtrA2^HM05030

(Qi et al., 2016)

YME1L^del has rhabdomere | progressive phenotype, suppressible by Scer\GAL4^da.PU/Hsap\YME1L1^UAS.GFP

(Qi et al., 2016)

YME1L^del has eye photoreceptor cell | progressive phenotype, suppressible by Scer\GAL4^da.PU/Hsap\YME1L1^UAS.GFP

(Qi et al., 2016)

YME1L^del has eye photoreceptor cell | progressive phenotype, suppressible by BacA\p35^GMR.PH

(Qi et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either Sod1^Scer\UAS.cAa, Sod2^Scer\UAS.cMa, Dark^{dsRNA.Scer\UAS.cLa}, Dronc^HMS00758, HtrA2^HM05030 under the control of Scer\GAL4^da.PU suppresses the age-dependent loss of rhabdomeres seen in YME1L^del homozygotes.

Expression of either HtrA2^HM05030 or Dronc^HMS00758 under the control of Scer\GAL4^da.PU suppresses the age-dependent locomotor defect seen in YME1L^del homozygotes.

Expression of Dark^{dsRNA.Scer\UAS.cLa} under the control of Scer\GAL4^da.PU partially suppresses the age-dependent locomotor defect seen in YME1L^del homozygotes.

Diap1^GMR.PH suppresses the locomotor defect and age-dependent loss of rhabdomeres seen in YME1L^del homozygotes.

Expression of either Sod1^Scer\UAS.cAa or Sod2^Scer\UAS.cMa under the control of Scer\GAL4^da.PU partially suppresses the age-dependent locomotor defect seen in YME1L^del homozygotes.

Expression of either Sod1^Scer\UAS.cAa or Sod2^Scer\UAS.cMa under the control of Scer\GAL4^da.PU extends the lifespan of YME1L^del homozygotes.

(Qi et al., 2016)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\YME1L1^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^da.PU suppresses the age-dependent phenotypes (defects in climbing ability, bang sensitivity and neurodegeneration of photoreceptor neurons) seen in YME1L^del homozygotes.

BacA\p35^GMR.PH suppresses the age-dependent loss of rhabdomeres seen in YME1L^del homozygotes.

(Qi et al., 2016)

Complementation and Rescue Data

Rescued by

YME1L^del is rescued by Scer\GAL4^da.PU/YME1L^UAS.GFP

(Qi et al., 2016)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

95273

w¹¹¹⁸; YME1L^del/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

YME1L^del

dYME1L^del

(Qi et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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