FlyBase Allele Report: Dmel\Dronc[HMS00758]

General Information

Symbol

Dmel\Dronc^HMS00758

Species

D. melanogaster

Name

FlyBase ID

FBal0257441

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00758}

Also Known As

UAS-dronc RNAi, UAS-dronc-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00758}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00758

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cSa

(Asadzadeh et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with Scer\GAL4^ap-md544

(Shinoda et al., 2019)

Detailed Description

Statement

Reference

The expression of Dronc^HMS00758 under the control of Scer\GAL4^ap-md544, with or without Dicer-2 (for a more efficient RNAi), leads to opaque but straight wings, which respectively indicate apoptosis but no growth inhibition during development.

(Shinoda et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dronc^HMS00758/Scer\GAL4^mirr-DE is a suppressor of increased cell death | larval stage phenotype of hid^GMR.PG

(Farrell et al., 2022)

Dronc^HMS00758/Scer\GAL4^mirr-DE is a suppressor | partially of decreased size | adult stage phenotype of hid^GMR.PG

(Farrell et al., 2022)

Dronc^HMS00758, Scer\GAL4^ey.PU is a suppressor of increased occurrence of cell division | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

Dronc^HMS00758/Scer\GAL4^da.PU is a suppressor of abnormal neuroanatomy | progressive phenotype of YME1L^del

(Qi et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dronc^HMS00758, Scer\GAL4^Act.PU is a suppressor of filamentous actin | somatic clone | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^Act.PU, hid^UAS.cUa

(Farrell et al., 2022)

Dronc^HMS00758/Scer\GAL4^mirr-DE is a suppressor of eye disc | larval stage phenotype of hid^GMR.PG

(Farrell et al., 2022)

Dronc^HMS00758/Scer\GAL4^mirr-DE is a suppressor | partially of eye | adult stage phenotype of hid^GMR.PG

(Farrell et al., 2022)

Dronc^HMS00758, Scer\GAL4^ey.PU is a suppressor of filamentous actin | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

Dronc^HMS00758, Scer\GAL4^ey.PU is a suppressor of eye disc | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

Dronc^HMS00758, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone | larval stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^Act.PU, hid^UAS.cUa

(Farrell et al., 2022)

Dronc^HMS00758/Scer\GAL4^da.PU is a suppressor of rhabdomere | progressive phenotype of YME1L^del

(Qi et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Dronc^HMS00758 suppresses the age-dependent locomotor defect and loss of rhabdomeres seen in YME1L^del homozygotes.

(Qi et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32963

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00758}attP2

NIG-Fly

HMS00758

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00758}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dronc^HMS00758

Dronc^IR

(Qi et al., 2016)

Nc^HMS00758

dronc^RNAi

(Xie et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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