FlyBase Allele Report: Hsap\APP[Aβ42.UAS.Tag:SS(nec)]

General Information

Symbol

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

Species

H. sapiens

Name

FlyBase ID

FBal0324202

Feature type

allele

Associated gene

Hsap\APP

Associated Insertion(s)

Carried in Construct

P{UAS-Aβ42.C}

Also Known As

Aβ_1-42, Aβ₄₂, Aβ1-42, Aβ42, Alz42, UAS-Aβ_1-42, UAS-Aβ42, UAS-Aβ₄₂

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Crowther et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Aβ42.C}

Cytology

Description

UASt regulatory sequences drive expression of the Tag:SS(nec) secretion signal peptide fused to the Aβ1-42 peptide.

(Crowther et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\APP

Tagged with

Tag:SS(nec)

signal sequence

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease 1

CEA

(Elovsson et al., 2024, Gerenu et al., 2021, Garrido-Maraver et al., 2020, Xie et al., 2019, Briffa et al., 2017, Zhang et al., 2017, Bergkvist et al., 2016, Ott et al., 2016, Poska et al., 2016, Shen et al., 2016, Sofola-Adesakin et al., 2016, Tabuchi et al., 2015, Hermansson et al., 2014, Hou et al., 2014)

CEC

(Zhu et al., 2022)

CEA with Hsap\APP^{3Q42.Aβ42.Tag:SS(rPENK)}

(Sofola-Adesakin et al., 2016)

model of Kennedy's disease

CEA

(Pandey et al., 2007)

model of Alzheimer's disease

CEA

(Bergkvist et al., 2020, Sun et al., 2018, Helmfors et al., 2015, Costa et al., 2011, Kumar et al., 2011, Zhao et al., 2010, Rival et al., 2009, Luheshi et al., 2007, Crowther et al., 2005)

CEA with Hsap\APP^UAS.cUa

(Bergkvist et al., 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Kennedy's disease

is ameliorated by HDAC6^UAS.Tag:V5

(Pandey et al., 2007)

model of Alzheimer's disease

is ameliorated by Fer1HCH^UAS.cRa

(Rival et al., 2009)

is exacerbated by Sod1^UAS.cAa

(Rival et al., 2009)

is ameliorated by Cat^UAS.cAa

(Rival et al., 2009)

is ameliorated by Fer2LCH^UAS.cRa

(Rival et al., 2009)

is ameliorated by Hsap\LYZ^{UAS.Tag:SS(nec)}

(Helmfors et al., 2015)

is exacerbated by Hsap\HYCC1^UAS.cSa

(Sun et al., 2018)

is ameliorated by Hyccin^KK108796

(Sun et al., 2018)

is ameliorated by Ttc7^k15603

(Sun et al., 2018)

is exacerbated by Ttc7^EY09582

(Sun et al., 2018)

model of Alzheimer's disease 1

is ameliorated by Hsap\SFTPC^{BRICHOS.UAS.Tag:SS(hSFTPB)}

(Poska et al., 2016, Hermansson et al., 2014)

is ameliorated by Hsap\ITM2B^{BRICHOS.UAS.Tag:SS(hSFTPB)}

(Poska et al., 2016)

is ameliorated by Lnk^UAS.cSb

(Shen et al., 2016)

is exacerbated by Lnk^unspecified

(Shen et al., 2016)

is ameliorated by Hsap\TXN^80.UAS

(Gerenu et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight | progressive, with Scer\GAL4^shot-OK307

(Zhao et al., 2010)

abnormal locomotor behavior, with Scer\GAL4^elav-C155

(Helmfors et al., 2015, Crowther et al., 2005)

abnormal locomotor behavior | adult stage, with Scer\GAL4^shot-OK307

(Sun et al., 2018)

abnormal locomotor behavior | progressive, with Scer\GAL4^elav-C155

(Costa et al., 2011)

abnormal locomotor rhythm | progressive, with Scer\GAL4^elav.PU

(Long et al., 2014)

abnormal neuroanatomy, with Scer\GAL4^shot-OK307

(Lin et al., 2014)

abnormal neurophysiology | adult stage, with Scer\GAL4^shot-OK307

(Sun et al., 2018)

abnormal neurophysiology | adult stage | progressive, with Scer\GAL4^shot-OK307

(Zhao et al., 2010)

short lived, with Scer\GAL4^elav-C155

(Helmfors et al., 2015, Costa et al., 2011, Luheshi et al., 2010, Crowther et al., 2005)

short lived, with Scer\GAL4^shot-OK307

(Sun et al., 2018, Zhao et al., 2010)

visible, with Scer\GAL4^elav-C155

(Crowther et al., 2005)

visible, with Scer\GAL4^GMR.PF

(Kumar et al., 2011, Pandey et al., 2007)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell, with Scer\GAL4^shot-OK307

(Sun et al., 2018, Lin et al., 2014)

eye, with Scer\GAL4^elav-C155

(Crowther et al., 2005)

eye, with Scer\GAL4^GMR.PF

(Pandey et al., 2007)

mitochondrion | adult stage | progressive, with Scer\GAL4^shot-OK307

(Zhao et al., 2010)

synaptic vesicle | adult stage | progressive, with Scer\GAL4^shot-OK307

(Zhao et al., 2010)

tergosternal muscle cell, with Scer\GAL4^shot-OK307

(Lin et al., 2014)

Detailed Description

Statement

Reference

Adults expressing Hsap\APP^{Aβ42.UAS.Tag:SS(nec)} under the control of Scer\GAL4^shot-OK307 show a significant decrease in climbing ability, as well as a significant decrease in neurotransmission to DM muscles, as compared to controls.

(Sun et al., 2018)

Expression of Hsap\APP^{Aβ42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^elav-C155 results in a significant decrease in lifespan and a significant increase in locomotor defects, as compared to controls.

(Helmfors et al., 2015)

At ages less than 3 weeks, the latency of evoked dorsal longitudinal flight muscle (DLM) and Tergotrochanter muscle (TTM) excitatory junctional potentials (EJPs) is about 0.8ms in flies expressing one or two copies of Hsap\APP^{1-42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^OK307 (compared to 1.2ms in controls). At ages over 3 weeks, the latencies of evoked DLM and TTM EJPs in flies expressing one or two copies of Hsap\APP^{1-40.Scer\UAS.T:SS-nec} are significantly increased, in a dosage-dependent manner, demonstrating a slowing of neurotransmission in both the TTM and DLP pathways. In some 2xHsap\APP^{1-42.Scer\UAS.T:SS-nec} flies over 3 weeks old, neither DLM nor TTM EJPs are evoked by brain stimulation, demonstrating a loss of neurotransmission. Failure of neurotransmission in the TTM pathway is more frequent than in the DLM pathway, suggesting that the TTM pathway is more susceptible to the intraneuronal accumulation of Hsap\APP, although the TTM pathway is relatively shorter and contains fewer synapses.

(Lin et al., 2014)

Expression of Hsap\APP^{1-42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^elav.PU does not significantly shorten lifespan compared to controls.

Flies expressing Hsap\APP^{1-42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^elav.PU do not show any defects in locomotor rhythm in LD (12 hours light, 12 hours dark). In DD (total darkness) no different from controls is seen at 5 or 35 days, but a substantial difference in rhythm is seen at 50 days.

(Long et al., 2014)

Adult flies expressing Hsap\APP^{1-42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^elav-C155 show significantly decreased median lifespan relative to controls and rapid age-progressive loss of climbing ability.

(Costa et al., 2011)

Expression of Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^GMR.PF results in age-dependent degeneration of photoreceptor cells.

Expression of Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155 results in an age-dependent decrease in locomotor activity compared to controls flies of the same age.

(Kumar et al., 2011)

Flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155 display significantly increased survival when cultured on food containing 1000μ YM-F24 (an iron-specific metal chelator).

(Liu et al., 2011)

Expression of two copies of Hsap\APP^{1-42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^shot-OK307 significantly accelerates the age-related decline in the flight ability of adult flies and shortens adult lifespan relative to controls. It also hastens the age-related decline in neurotransmission functionality: the success rate of eliciting excitatory junction potentials (EJP) in the dorsal longitudinal muscle (DLM) fibers in response to brain stimulation is much lower compared to controls and decreases more steeply with the number of stimulations and enhances the age-progressive increase in synaptic transmission fatigue rate. The neurotransmission along the tergotrochanteral muscle pathway is affected to a much lesser degree. Expression of two copies of Hsap\APP^{1-42.Scer\UAS.T:SS-nec} also leads to age-progressive depletion of synaptic vesicles, their increased size and heterogeneity, depletion of presynaptic mitochondria (as well as slightly higher frequency of damaged mitochondria) and accumulation of presynaptic vacuoles compared to age-matched controls. Neither the mean area of the mitochondria nor the number of boutons on the neuromuscular junction is significantly changed by expressing either two or just one copy of Hsap\APP^{1-42.Scer\UAS.T:SS-nec}. Expression of just one copy also has much more subtle effect on flight capability of adult flies compared to when two copies are used, and it does not significantly change adult survival rate but it does reduce the DLM EJP success rate.

(Zhao et al., 2010)

The metal chelator clioquinol reduces the toxic effects of Scer\GAL4^elav-C155-driven Hsap\APP^{Scer\UAS.T:nec} overexpression.

(Rival et al., 2009)

Flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^unspecified have a median survival of about 24 days.

(Luheshi et al., 2007)

Expression of Hsap\APP^{Aβ42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^GMR.PF leads to a degenerative rough eye phenotype.

(Pandey et al., 2007)

Animals expressing Hsap\APP^{A&bgr1-42.Scer\UAS} under the control of Scer\GAL4^hs.2sev do not show embryonic lethality.

(Kinghorn et al., 2006)

Expression of Hsap\APP^{Scer\UAS.T:nec} driven by Scer\GAL4^elav-C155 results in a dose dependent rough eye phenotype.

Flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155 have a shorter lifespan than flies without a transgene. This effect is dependent on the dose of Hsap\APP^{Scer\UAS.T:nec}. Treatment with MK-801 markedly prolongs the survival of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155. Feeding these flies with azo-dye Congo Red from the time of hatching has no effect on survival.

Flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155 show accelerated decline in climbing behaviour relative to control flies, becoming immobile by day 10.

(Crowther et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal locomotor behavior | adult stage phenotype, enhanceable by Hsap\HYCC1^UAS.cSa, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has short lived phenotype, enhanceable by Hsap\HYCC1^UAS.cSa, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal neurophysiology | adult stage phenotype, enhanceable by Hsap\HYCC1^UAS.cSa, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal locomotor behavior | adult stage phenotype, enhanceable by Ttc7^EY09582, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has short lived phenotype, enhanceable by Ttc7^EY09582, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal neurophysiology | adult stage phenotype, enhanceable by Ttc7^EY09582, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, enhanceable by Sod1^UAS.cAa, Scer\GAL4^elav-C155

(Rival et al., 2009)

NOT Enhanced by

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has short lived phenotype, non-enhanceable by Saur\spa^{Z.UAS.Tag:MYC,Tag:SS(nec)}, Scer\GAL4^elav-C155

(Luheshi et al., 2010)

Suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal locomotor behavior | adult stage phenotype, suppressible by Hyccin^KK108796, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal locomotor behavior | adult stage phenotype, suppressible by Ttc7^k15603/Ttc7[+]

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has short lived phenotype, suppressible by Hyccin^KK108796, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has short lived phenotype, suppressible by Ttc7^k15603/Ttc7[+]

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal neurophysiology | adult stage phenotype, suppressible by Hyccin^KK108796, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has abnormal neurophysiology | adult stage phenotype, suppressible by Ttc7^k15603/Ttc7[+]

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, suppressible by Hsap\LYZ^{UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Helmfors et al., 2015)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Hsap\LYZ^{UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Helmfors et al., 2015)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Saur\spa^{ZAβ3.UAS.Tag:MYC,Tag:SS(nec)}, Scer\GAL4^elav-C155

(Luheshi et al., 2010)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Saur\spa^{2.ZAβ3.UAS.Tag:MYC,Tag:SS(nec)}, Scer\GAL4^elav-C155

(Luheshi et al., 2010)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, suppressible by Cat^UAS.cAa, Scer\GAL4^elav-C155

(Rival et al., 2009)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, suppressible by Fer1HCH^UAS.cRa, Scer\GAL4^elav-C155

(Rival et al., 2009)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, suppressible by GstS1^UASp.cWa, Scer\GAL4^elav-C155

(Rival et al., 2009)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by HDAC6^UAS.Tag:V5, Scer\GAL4^GMR.PF

(Pandey et al., 2007)

NOT suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Saur\spa^{Z.UAS.Tag:MYC,Tag:SS(nec)}, Scer\GAL4^elav-C155

(Luheshi et al., 2010)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155 has abnormal locomotor behavior phenotype, non-suppressible by sni^UAS.cBa, Scer\GAL4^elav-C155

(Rival et al., 2009)

Suppressor of

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^hs.2sev is a suppressor of partially lethal - majority die phenotype of Hsap\SERPINI1^UAS.cKa, Scer\GAL4^hs.2sev

(Kinghorn et al., 2006)

NOT Suppressor of

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^Act5C.PU is a non-suppressor of partially lethal - majority die | embryonic stage phenotype of Hsap\SERPINA1^UAS.cKa, Scer\GAL4^Act5C.PU

(Kinghorn et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has dorsal longitudinal indirect flight muscle cell phenotype, enhanceable by Hsap\HYCC1^UAS.cSa, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has dorsal longitudinal indirect flight muscle cell phenotype, enhanceable by Ttc7^EY09582, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Suppressed by

Statement

Reference

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has dorsal longitudinal indirect flight muscle cell phenotype, suppressible by Hyccin^KK108796, Scer\GAL4^shot-OK307

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^shot-OK307 has dorsal longitudinal indirect flight muscle cell phenotype, suppressible by Ttc7^k15603/Ttc7[+]

(Sun et al., 2018)

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by HDAC6^UAS.Tag:V5, Scer\GAL4^GMR.PF

(Pandey et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\LYZ^{Scer\UAS.T:SS-nec} suppresses the decrease in lifespan and partially suppresses the locomotor defects seen in flies expressing Hsap\APP^{Aβ42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^elav-C155.

(Helmfors et al., 2015)

Expression of Hsap\APP^{1-42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^elav.PU in a per⁰¹ mutant background does not significantly shorten lifespan compared to controls.

per⁰¹ enhances the climbing defects seen when Hsap\APP^{1-42.Scer\UAS.T:SS-nec} is expressed under the control of Scer\GAL4^elav.PU, but only in younger (5 day old) flies. No effect is seen at 15, 35 and 50 days.

(Long et al., 2014)

Expression of Fer1HCH^VDRC.cUa in flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155 reduces hatching efficiency.

Expression of Fer2LCH^VDRC.cUa in flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155 reduces hatching efficiency.

(Liu et al., 2011)

Co-expression of Saur\spa^{ZAβ3.Scer\UAS.T:Hsap\MYC,T:SS-nec} using Scer\GAL4^elav-C155 significantly prolongs the lifespan of flies expressing Hsap\APP^{Scer\UAS.T:SS-nec} alone.

Co-expression of Saur\spa^{2.ZAβ3.Scer\UAS.T:Hsap\MYC,T:SS-nec} using Scer\GAL4^elav-C155 restores the lifespan of flies expressing Hsap\APP^{Scer\UAS.T:SS-nec} alone to wild-type levels.

(Luheshi et al., 2010)

Overexpression of Fer1HCH^Scer\UAS.cRa suppresses the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of Cat^Scer\UAS.cAa suppresses the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of Sod^Scer\UAS.cAa accelerates the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of GstS1^{Scer\UAS.P\T.cWa} weakly suppresses the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of sni^Scer\UAS.cBa does not significantly suppress the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

(Rival et al., 2009)

Co-expression of HDAC6^{Scer\UAS.T:SV5\V5} partially suppresses the rough eye phenotype of flies expressing Hsap\APP^{Aβ42.Scer\UAS.T:SS-nec} under the control of Scer\GAL4^GMR.PF.

(Pandey et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Aβ WT

(Kumar et al., 2011)

Aβ42

(Costa et al., 2011)

Aβ₄₂

(Hou et al., 2014)

Hsap\APP^{1-42.Scer\UAS.T:SS-nec}

Hsap\APP^{Aβ1-42.Scer\UAS}

Hsap\APP^{Aβ42.Scer\UAS.T:SS-nec}

Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

Hsap\APP^{Scer\UAS.T:SS-nec}

Hsap\APP^{Scer\UAS.T:nec}

Name Synonyms

Secondary FlyBase IDs

FBal0248067
FBal0197912

References (34)

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