FB2024_04 , released June 25, 2024
Allele: Dmel\OrcoCBSΔ.UAS.mCherry
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General Information
Symbol
Dmel\OrcoCBSΔ.UAS.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0325832
Feature type
allele
Associated gene
Dmel\Orco
Associated Insertion(s)
Carried in Construct
P{UAS-Orco.CBSΔ.mCherry}
Key Links
Transgenic product class
inframe_deletion
(Bahk and Jones, 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Bahk and Jones, 2016)
Mutagen
in vitro construct
(Bahk and Jones, 2016)
Progenitor genotype
Carried in construct
P{UAS-Orco.CBSΔ.mCherry}
Cytology
Description

UAS regulatory sequences drive expression of Orco cDNA with deletions in the N- (S-A-I) and C (E-R) -termini of the putative Cam binding site, tagged with mCherry at the N-terminal.

(Bahk and Jones, 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Orco
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Orco1 homozygotes expressing OrcoCBSΔ.UAS.mCherry under the control of Scer\GAL4Orco.2.642.Hsim\VP22 show adult olfactory receptor neurons with an apparently normal dendritic morphology, as compared to controls.

      (Bahk and Jones, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4Orco.2.642.Hsim\VP22/OrcoCBSΔ.UAS.mCherry fails to rescue Orco1

      (Bahk and Jones, 2016)
      Comments

      The expression of OrcoCBSΔ.UAS.mCherry under the control of Scer\GAL4Orco.2.642.Hsim\VP22 does not rescue the lack of electrophysiological activity observed in the adult olfactory receptor neurons of Orco1 homozygotes.

      (Bahk and Jones, 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      OrcoCBSΔ.Scer\UAS.T:Disc\RFP-mCherry
      OrcoCBSΔ.UAS.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)