FB2024_03 , released June 25, 2024
Allele: Dmel\Herc4C-A.UAS
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General Information
Symbol
Dmel\Herc4C-A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0327466
Feature type
allele
Associated gene
Dmel\Herc4
Associated Insertion(s)
Carried in Construct
P{UAS-Herc4.C-A}
Key Links
Transgenic product class
missense_variant
(Aerne et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Aerne et al., 2015)
Mutagen
in vitro construct
(Aerne et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Herc4.C-A}
Cytology
Description

UAS regulates expression of HECT domain mutant version of Herc4 predicted to eliminate the E3 ligase activity of the protein.

(Aerne et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Herc4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Herc4C-A.Scer\UAS under the control of Scer\GAL4rn.PU leads to insignificant changes in wing area, as compared to controls.

      (Aerne et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Herc4C-A.UAS, Scer\GAL4rn.PU is a non-suppressor of wing | adult stage phenotype of Scer\GAL4rn.PU, savUAS.WT

      (Aerne et al., 2015)

      Herc4C-A.UAS, Scer\GAL4rn.PU is a non-suppressor of wing | adult stage phenotype of Scer\GAL4rn.PU, savS413A.UAS

      (Aerne et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of Herc4C-A.Scer\UAS does not suppress the decreased wing area observed upon the expression of either savScer\UAS.WT or savS413A.Scer\UAS under the control of Scer\GAL4rn.PU.

      (Aerne et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Herc4C-A.Scer\UAS
      Herc4C-A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)