FlyBase Allele Report: Dmel\hh[ΔaptDB1]

General Information

Symbol

Dmel\hh^ΔaptDB1

Species

D. melanogaster

Name

FlyBase ID

FBal0335647

Feature type

allele

Associated gene

Dmel\hh

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Wang et al., 2017)

Mutagen

CRISPR/Cas9

(Wang et al., 2017)

Progenitor genotype

Cytology

Description

Deletion of 11 nucleotides within the apt binding site of hh.

(Wang et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:23,142,253..23,142,263 [-]

Comment:

Deletion of 11 nucleotides within the apt binding site of hh.

(Wang et al., 2017)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Wang et al., 2017)

abnormal size | adult stage (with hh²)

(Wang et al., 2017)

visible

(Wang et al., 2017)

visible (with hh²)

(Wang et al., 2017)

Phenotype Manifest In

crossvein | ectopic (with hh²)

(Wang et al., 2017)

wing

(Wang et al., 2017)

wing (with hh²)

(Wang et al., 2017)

Detailed Description

Statement

Reference

hh^ΔaptDB1/hh^ΔaptDB1 mutant adults exhibit a decrease in the size of the adult wing, and reduces the area between vein L3 and vein L4 as a percentage of the whole wing area, as compared to controls; but hh^ΔaptDB1/+ mutants appear normal.

hh^ΔaptDB1/hh² mutant adults exhibit smaller wings with an ectopic crossvein, as compared to controls.

(Wang et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hh^ΔaptDB1 is an enhancer of visible phenotype of Scer\GAL4^Bx-MS1096, smo^PKA12.UAS

(Wang et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

hh^ΔaptDB1 is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, smo^PKA12.UAS

(Wang et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of hh^ΔaptDB1 enhances the fused wing phenotype of flies expressing smo^{PKA12.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096.

(Wang et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hh^ΔaptDB1

(Wang et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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