FlyBase Allele Report: Dmel\spoon[KH.UAS.Tag:HA]

General Information

Symbol

Dmel\spoon^{KH.UAS.Tag:HA}

Species

D. melanogaster

Name

FlyBase ID

FBal0337789

Feature type

allele

Associated gene

Dmel\spoon

Associated Insertion(s)

Carried in Construct

P{UAS-spoon.KH.HA}

Key Links

Transgenic product class

inframe_deletion

(Tripathi et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Tripathi et al., 2016)

Mutagen

in vitro construct

(Tripathi et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-spoon.KH.HA}

Cytology

Description

UAS regulatory sequences drive expression of the KH domain of spoon, tagged with Tag:HA.

(Tripathi et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

spoon

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates spinocerebellar ataxia type 8

modeled by Hsap\ATXN8OS^CTG112.UAS

(Tripathi et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

spoon^{KH.UAS.Tag:HA}/Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Das et al., 2023)

spoon^{KH.UAS.Tag:HA}/Scer\GAL4^GMR.PU is a non-enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Das et al., 2023)

Suppressor of

Statement

Reference

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of increased cell death | third instar larval stage phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of visible | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

NOT Suppressor of

Statement

Reference

spoon^{KH.UAS.Tag:HA}/Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Das et al., 2023)

spoon^{KH.UAS.Tag:HA}/Scer\GAL4^GMR.PU is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Das et al., 2023)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

spoon^{KH.UAS.Tag:HA}/Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Das et al., 2023)

Suppressor of

Statement

Reference

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of ommatidium phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of optic nerve phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of eye disc | third instar larval stage phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of nucleus | third instar larval stage phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU is a suppressor of cytoplasm | third instar larval stage phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580 is a suppressor | partially of wing | progressive phenotype of Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

NOT Suppressor of

Statement

Reference

spoon^{KH.UAS.Tag:HA}/Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, egr^GS9830

(Das et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The disorganization of the adult eye ommatidial lattice, disarrayed axonal projection in the optic nerve along with the increased cell death of developing photoreceptors and formation of nuclear as well as cytoplasmic toxic RNAi foci in larval eye discs characteristic for flies expressing Hsap\ATXN8OS^{CTG112.Scer\UAS} under the control of Scer\GAL4^GMR.PU is significantly improved by co-expression of spoon^{KH.UAS.Tag:HA}.

Similarly, expression of spoon^{KH.UAS.Tag:HA} also ameliorates the age-progressive wing posture and climbing ability defects in flies expressing Hsap\ATXN8OS^{CTG112.Scer\UAS} under the Scer\GAL4^Mhc.F3-580 driver.

(Tripathi et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

spoon^{KH.Scer\UAS.T:Ivir\HA1}

spoon^{KH.UAS.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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