FlyBase Allele Report: Dmel\Sting[ΔRG5]

General Information

Symbol

Dmel\Sting^ΔRG5

Species

D. melanogaster

Name

FlyBase ID

FBal0340353

Feature type

allele

Associated gene

Dmel\Sting

Associated Insertion(s)

TI{TI}Sting^ΔRG5

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Martin et al., 2018)

Mutagen

CRISPR/Cas9

(Martin et al., 2018)

Progenitor genotype

Associated Insertion(s)

TI{TI}Sting^ΔRG5

Cytology

Description

Replacement of base pairs 1381-1993 of the Sting gene, which includes a majority of the second exon, with a w^+* marker.

(Martin et al., 2018)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2R:9,844,066..9,844,678 [+]

Comment:

"A 613bp deletion removes the middle third of the Sting coding sequence. These sequences have been replaced with a ""mini-white"" gene."

(Goodman, 2019.1.24)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 2

modeled by park²⁵

(Moehlman et al., 2023)

modeled by park¹

(Moehlman et al., 2023)

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Moehlman et al., 2023)

modeled by Pink1⁵

(Moehlman et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage

(Martin et al., 2018)

abnormal locomotor behavior | adult stage

(Lee et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sting^ΔRG5 homozygous mutants display a small but significant decrease in climbing ability in young (2 days old) flies, but not in aged (20 days old) flies, when compared to heterozygous and wild-type controls.

Neither homozygous nor heterozygous mutants of Sting^ΔRG5 display any obvious disruption in the tissue and mitochondrial integrity in the flight muscles when compared to controls.

Sting^ΔRG5 mutation alone does not lead to any changes in lifespan when compared to controls.

(Lee et al., 2020)

Sting^ΔRG5 mutants show a significantly increased mortality upon infection with Listeria monocytogenes, as compared to controls.

(Martin et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sting^ΔRG5 is an enhancer of short lived phenotype of Rnor\Apobec1^{Tag:Mito(hATP5F1B),Tag:HA}, Scer\GAL4^da.G32

(Lee et al., 2020)

park²⁵/Sting^ΔRG5 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Rnor\Apobec1^{Tag:Mito(hATP5F1B),Tag:HA}, Scer\GAL4^da.G32

(Lee et al., 2020)

Sting^ΔRG5 is an enhancer of short lived phenotype of Rnor\Apobec1^{Tag:Mito(hATP5F1B),Tag:HA}, Scer\GAL4^da.G32, park²⁵

(Lee et al., 2020)

NOT Enhancer of

Statement

Reference

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of visible | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of visible | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Rnor\Apobec1^{Tag:Mito(hATP5F1B),Tag:HA}, Scer\GAL4^da.G32

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of visible | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of visible | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Suppressor of

Statement

Reference

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of visible | adult stage phenotype of Pink1⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of visible | adult stage phenotype of Pink1^B9

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of visible | adult stage phenotype of park¹

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of decreased rate of adult locomotory behavior phenotype of park¹

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of visible | adult stage phenotype of park²⁵

(Moehlman et al., 2023)

Df(2R)BSC133/Sting^ΔRG5 is a suppressor of visible | adult stage phenotype of park²⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of decreased rate of adult locomotory behavior phenotype of park²⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of increased cell death | adult stage phenotype of park²⁵

(Moehlman et al., 2023)

NOT Suppressor of

Statement

Reference

Sting^ΔRG5 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Rnor\Apobec1^{Tag:Mito(hATP5F1B),Tag:HA}, Scer\GAL4^da.G32

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of visible | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of visible | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of visible | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of visible | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Other

Statement

Reference

Scer\GAL4^da.G32, Sting^ΔRG5, Sting^UAS.Tag:V5, park²⁵ has visible | adult stage phenotype

(Moehlman et al., 2023)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Sting[+]/Sting^ΔRG5 is a non-enhancer of adult thorax phenotype of Pink1^B9

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of adult thorax phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of adult thorax phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-enhancer of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-enhancer of adult thorax phenotype of Pink1^B9

(Lee et al., 2020)

Suppressor of

Statement

Reference

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of adult thorax phenotype of Pink1⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of indirect flight muscle phenotype of Pink1⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of wing phenotype of Pink1⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of indirect flight muscle phenotype of Pink1^B9

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of wing phenotype of Pink1^B9

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of adult thorax phenotype of park¹

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of indirect flight muscle phenotype of park¹

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of wing phenotype of park¹

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of mitochondrion phenotype of park¹

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of adult thorax phenotype of park²⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of indirect flight muscle phenotype of park²⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor of wing phenotype of park²⁵

(Moehlman et al., 2023)

Df(2R)BSC133/Sting^ΔRG5 is a suppressor of adult thorax phenotype of park²⁵

(Moehlman et al., 2023)

Df(2R)BSC133/Sting^ΔRG5 is a suppressor of indirect flight muscle phenotype of park²⁵

(Moehlman et al., 2023)

Df(2R)BSC133/Sting^ΔRG5 is a suppressor of wing phenotype of park²⁵

(Moehlman et al., 2023)

Sting^ΔRG5/Sting^ΔRG5 is a suppressor | partially of mitochondrion phenotype of park²⁵

(Moehlman et al., 2023)

NOT Suppressor of

Statement

Reference

Sting[+]/Sting^ΔRG5 is a non-suppressor of adult thorax phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of adult thorax phenotype of Pink1^B9

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of adult thorax phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of adult thorax phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Sting[+]/Sting^ΔRG5 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Sting^ΔRG5/Sting^ΔRG5 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Other

Statement

Reference

Scer\GAL4^da.G32, Sting^ΔRG5, Sting^UAS.Tag:V5, park²⁵ has wing phenotype

(Moehlman et al., 2023)

Scer\GAL4^da.G32, Sting^ΔRG5, Sting^UAS.Tag:V5, park²⁵ has adult thorax phenotype

(Moehlman et al., 2023)

Scer\GAL4^da.G32, Sting^ΔRG5, Sting^UAS.Tag:V5, park²⁵ has mitochondrion phenotype

(Moehlman et al., 2023)

Scer\GAL4^da.G32, Sting^ΔRG5, Sting^UAS.Tag:V5, park²⁵ has indirect flight muscle phenotype

(Moehlman et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Neither Sting^ΔRG5 homozygous nor heterozygous mutation modifies the impaired climbing ability, thoracic indentations, and disrupted tissue and mitochondrial integrity in the flight muscles phenotypes of young park²⁵ and Pink1^B9 mutants.

In young flies, Sting^ΔRG5 and park²⁵ mutations together enhance the impaired climbing ability phenotype observed as a result of expression of Rnor\Apobec1^{Tag:Mito(hATP5F1B),Tag:HA} under the control of Scer\GAL4^da.G32, while Sting^ΔRG5 or park²⁵ mutation alone does not modify that phenotype.

(Lee et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sting^ΔRG5

(Lee et al., 2020)

dmSTING^ΔRG5

(Martin et al., 2018)

sting^ΔRG5

(Moehlman et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (4)

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