FlyBase Allele Report: Dmel\Pink1[5]

General Information

Symbol

Dmel\Pink1⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0196293

Feature type

allele

Associated gene

Dmel\Pink1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Clark et al., 2006)

Progenitor genotype

Pink1^G900

(Clark et al., 2006)

Cytology

Description

Imprecise excision of the insertion in Pink1^G900, resulting in a deletion of Pink1 sequences, including the mitochondrial targeting sequence and over 70% of the kinase domain.

(Clark et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease 6

CEC

(Moehlman et al., 2023, Liu et al., 2022, Paradis et al., 2022)

CEA

(Zhang et al., 2017, Tsai et al., 2014)

model of early-onset Parkinson's disease

CEA

(West et al., 2015)

model of Hirschsprung's disease

CEA

(Myers et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Parkinson's disease 6

is ameliorated by Creld^UAS.Tag:HA

(Paradis et al., 2022)

is ameliorated by Sting^ΔRG5

(Moehlman et al., 2023)

is ameliorated by TER94^UAS.cCa

(Zhang et al., 2017)

is exacerbated by park^{K56R.K77R.UAS}

(Liu et al., 2022)

is exacerbated by park^K56R.UAS

(Liu et al., 2022)

is exacerbated by park^K77R.UAS

(Liu et al., 2022)

is exacerbated by park^UAS.cSa

(Liu et al., 2022)

model of Parkinson's disease

is ameliorated by Mul1^UAS.cYa

(Yun et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult somatic muscle cell of thorax | adult stage

(Yang et al., 2022)

adult thorax

(Moehlman et al., 2023, Yang et al., 2022)

adult thorax | dorsal

(Yun et al., 2014)

axon | adult stage

(Smith et al., 2019)

axon | third instar larval stage

(Tsai et al., 2018)

dendrite | third instar larval stage

(Tsai et al., 2018)

dopaminergic neuron | progressive

(Yun et al., 2008)

dopaminergic PPL1 neuron

(Yun et al., 2014)

embryonic/larval hypocerebral ganglion | embryonic stage

(Myers et al., 2018)

embryonic/larval hypodermal muscle cell | third instar larval stage

(Tsai et al., 2018)

embryonic/larval neuromuscular junction | third instar larval stage

(Tsai et al., 2018)

embryonic frontal ganglion

(Myers et al., 2018)

indirect flight muscle

(Moehlman et al., 2023)

indirect flight muscle cell

(Yun et al., 2014, Deng et al., 2008, Yun et al., 2008, Clark et al., 2006)

indirect flight muscle cell | progressive

(Tsai et al., 2018)

larval ventral nerve cord | third instar larval stage

(Tsai et al., 2018)

minor mitochondrial derivative

(Deng et al., 2008)

mitochondrial crista

(Deng et al., 2008, Yun et al., 2008)

mitochondrial crista & indirect flight muscle

(Clark et al., 2006)

mitochondrial crista | adult stage | progressive

(Tsai et al., 2018)

mitochondrial crista | third instar larval stage

(Tsai et al., 2018)

mitochondrial crista junction | third instar larval stage

(Tsai et al., 2018)

mitochondrial derivative

(Yun et al., 2008)

mitochondrion

(Yun et al., 2014, Deng et al., 2008, Yun et al., 2008)

mitochondrion | adult stage

(Yang et al., 2022, Mori et al., 2019, Smith et al., 2019)

mitochondrion | adult stage | progressive

(Tsai et al., 2018)

mitochondrion | third instar larval stage

(Tsai et al., 2018)

Nebenkern

(Deng et al., 2008, Yun et al., 2008, Clark et al., 2006)

paraesophageal ganglion | embryonic stage

(Myers et al., 2018)

spermatid

(Yun et al., 2008)

synapse | third instar larval stage

(Tsai et al., 2018)

wing

(Moehlman et al., 2023, Deng et al., 2008)

Detailed Description

Statement

Reference

The DA neurons of Pink1⁵ adults exhibit aggregated or elongated mitochondria.

(Mori et al., 2019)

Pink1⁵/+ heterozygous mutants have significantly reduced mitochondrial length and significantly increased mitochondrial number in axons of adult neurons, compared to controls.

(Smith et al., 2019)

Pink1⁵ mutant embryos display asymmetric frontal ganglia and altered esophageal ganglia, as compared to controls.

(Myers et al., 2018)

Pink1⁵ hemizygous male third instar larvae show nearly fully penetrant mitochondrial defects in the body wall muscles, including a rounder shape, an "onion"-like crista phenotype, a "vacuole" phenotype and decreased number of crista junctions, but no changes in mitochondria size; there are no obvious muscle degeneration signs in these larvae. In the nervous system, mitochondria cristae defects are observed in the ventral nerve cord neuropils (synapses, dendrites, and axons, but not in the cell bodies), in the segmental nerves (axons), and at the neuromuscular junctions. These larvae have impaired crawling ability.

In 3 days old Pink1⁵ hemizygous male adults, indirect flight muscles present vacuolated and "onion"-like mitochondria, all of which convert to vacuolated mitochondria at day 5; at day 5 these indirect flight muscles show signs of degeneration.

(Tsai et al., 2018)

Pink1⁵ mutant escapers do not exhibit lipid droplet accumulation. Aconitase activity is reduced in these mutants and there is a strong correlation between decreased aconitase enzymatic activity and the number of lipid droplets per ommatidium, suggesting reactive oxygen species may play a role in lipid droplet accumulation.

(Liu et al., 2015)

Pink1⁵ mutant flies show elevated response across a range of spatiotemporal frequencies of contrast-reversing sine-wave gratings as compared to responses from control flies.

(West et al., 2015)

PPL1 dopaminergic neurons in the brain have abnormally clumped mitochondria in mutant adults.

Mutants show severe defects in mitochondrial morphology in the indirect flight muscle (IFM): mitochondrial size is irregular and clumping of mitochondria are seen. Many of the mitochondria are swollen and have fragmented cristae. The mutant muscle shows cell death and vacuolisation, indicating degeneration. The mutant adults have a thoracic indentation due to this degeneration of the IFM.

(Yun et al., 2014)

Mutant spermatids show vacuolated onion-stage nebenkerns, and in subsequent stages, show only one mitochondrial derivative rather than the normal two seen in wild-type spermatids. A cross-section through mutant sperm tails shows the presence of only the major mitochondrial derivative, but not the minor mitochondrial derivative.

Indirect flight muscles of mutant flies show severe defects in mitochondrial morphology, including swollen mitochondria with broken cristae. Vacuolisation, indicative of degeneration, is seen in the indirect flight muscles.

Mutant adults have an abnormal wing posture.

(Deng et al., 2008)

Pink1⁵ mutant males exhibit mitochondrial morphology defects in the testes. Spermatids show vacuolisation in the spherical "onion stage" nebenkern. Only one mitochondrial derivative is seen during spermatid elongation (the "leaf blade" stage), as opposed to the two usually seen in wild type. Pink1⁵ mutant spermatids also exhibit dramatic defects in mitochondrial morphology during the post-individualisation stages.

An-age dependent decrease in the number of dopaminergic neurons is seen in Pink1⁵ mutant flies. Fewer neurons are observed in 40 day old flies at 25[o]C. Pink1⁵ mutant flies also show striking indirect flight muscle degeneration and severely disrupted mitochondrial morphology with broken cristae.

(Yun et al., 2008)

Indirect flight muscles of 1-2 day old mutant adults show a marked increase in TUNEL-positive nuclei compared to controls, indicating an increase in the number of apoptotic cells.

Mutant flies show a 59% reduction in resistance to paraquat and a 71% reduction in resistance to rotenone compared to controls. They are also more sensitive to dithiothreitol and to high concentrations of salt compared to wild-type flies.

Mutant males show vacuolation of Nebenkern in the testes.

The indirect flight muscles of 2 day old flies have mitochondria with fragmented cristae.

(Clark et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pink1⁵ has increased size | adult stage phenotype, enhanceable by clu^d00713/clu^d00713

(Yang et al., 2022)

Suppressed by

Statement

Reference

Pink1⁵ has visible | adult stage phenotype, suppressible | partially by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

Pink1⁵ has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^Act5C.PI/Creld^UAS.Tag:HA

(Paradis et al., 2022)

Pink1⁵ has visible | adult stage phenotype, suppressible by clu^UAS.cYa/Scer\GAL4^Mef2.PU

(Yang et al., 2022)

Pink1⁵ has increased cell death | adult stage phenotype, suppressible by clu^UAS.cYa/Scer\GAL4^Mef2.PU

(Yang et al., 2022)

Pink1⁵ has abnormal neuroanatomy | dominant | adult stage phenotype, suppressible | clone of cells by gfzf⁵⁴¹

(Smith et al., 2019)

Pink1⁵ has visible phenotype, suppressible by Mul1^UAS.cYa/Scer\GAL4^Mef2.PU

(Yun et al., 2014)

Pink1⁵ has increased cell death phenotype, suppressible by Mul1^UAS.cYa/Scer\GAL4^Mef2.PU

(Yun et al., 2014)

Pink1⁵ has visible phenotype, suppressible by Scer\GAL4^Mef2.PR/Marf^RNAi.CDS.UAS

(Deng et al., 2008)

Pink1⁵ has visible phenotype, suppressible by Marf^RNAi.UTR.UAS/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has visible phenotype, suppressible by Drp1^UAS.cDa/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has sterile phenotype, suppressible | partially by park^βTub85D.PC

(Clark et al., 2006)

Pink1⁵ has male sterile phenotype, suppressible | partially by Hsap\PINK1^βTub85D.PC

(Clark et al., 2006)

NOT suppressed by

Statement

Reference

Pink1⁵ has abnormal locomotor behavior | larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has increased cell death phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Mul1^LD.UAS

(Yun et al., 2014)

Pink1⁵ has visible phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Mul1^LD.UAS

(Yun et al., 2014)

Pink1⁵ has sterile phenotype, non-suppressible by HtrA2^βTub85D.PY

(Yun et al., 2008)

Suppressor of

Statement

Reference

Pink1⁵ is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

NOT Suppressor of

Statement

Reference

Pink1⁵/Pink1⁵ is a non-suppressor of visible | heat sensitive phenotype of HtrA2^UAS.cYa, Scer\GAL4^GMR.PF

(Yun et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pink1⁵ has mitochondrion | adult stage phenotype, enhanceable by clu^d00713/clu^d00713

(Yang et al., 2022)

Pink1⁵ has adult thorax | dorsal phenotype, enhanceable by Mul1^A6

(Yun et al., 2014)

NOT Enhanced by

Statement

Reference

Pink1⁵ has adult thorax | dorsal phenotype, non-enhanceable by park²⁵

(Yun et al., 2014)

Pink1⁵ has spermatid phenotype, non-enhanceable by HtrA2^NSO/Df(3R)ED5644

(Yun et al., 2008)

Pink1⁵ has Nebenkern phenotype, non-enhanceable by HtrA2^NSO/Df(3R)ED5644

(Yun et al., 2008)

Pink1⁵ has mitochondrial derivative phenotype, non-enhanceable by HtrA2^NSO/Df(3R)ED5644

(Yun et al., 2008)

Pink1⁵ has indirect flight muscle cell phenotype, non-enhanceable by HtrA2^RNAi.UAS.cYa/Scer\GAL4^Mef2.PR

(Yun et al., 2008)

Pink1⁵ has mitochondrion phenotype, non-enhanceable by HtrA2^RNAi.UAS.cYa/Scer\GAL4^Mef2.PR

(Yun et al., 2008)

Suppressed by

Statement

Reference

Pink1⁵ has adult thorax phenotype, suppressible | partially by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

Pink1⁵ has indirect flight muscle phenotype, suppressible | partially by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

Pink1⁵ has wing phenotype, suppressible | partially by Sting^ΔRG5/Sting^ΔRG5

(Moehlman et al., 2023)

Pink1⁵ has adult thorax phenotype, suppressible by clu^UAS.cYa/Scer\GAL4^Mef2.PU

(Yang et al., 2022)

Pink1⁵ has adult somatic muscle cell of thorax | adult stage phenotype, suppressible by clu^UAS.cYa/Scer\GAL4^Mef2.PU

(Yang et al., 2022)

Pink1⁵ has mitochondrion | adult stage phenotype, suppressible | clone of cells by gfzf⁵⁴¹

(Smith et al., 2019)

Pink1⁵ has axon | adult stage phenotype, suppressible | clone of cells by gfzf⁵⁴¹

(Smith et al., 2019)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista junction | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{UAS.cTa.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | adult stage | progressive phenotype, suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | adult stage | progressive phenotype, suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has indirect flight muscle cell | progressive phenotype, suppressible by Scer\GAL4^da.PU/Mitofilin^UAS.Tag:MYC

(Tsai et al., 2018)

Pink1⁵ has dopaminergic PPL1 neuron phenotype, suppressible by Scer\GAL4^ple.PF/Mul1^UAS.cYa

(Yun et al., 2014)

Pink1⁵ has mitochondrion phenotype, suppressible by Scer\GAL4^ple.PF/Mul1^UAS.cYa

(Yun et al., 2014)

Pink1⁵ has mitochondrion phenotype, suppressible by Mul1^UAS.cYa/Scer\GAL4^Mef2.PU

(Yun et al., 2014)

Pink1⁵ has indirect flight muscle cell phenotype, suppressible by Mul1^UAS.cYa/Scer\GAL4^Mef2.PU

(Yun et al., 2014)

Pink1⁵ has adult thorax | dorsal phenotype, suppressible by Mul1^UAS.cYa/Scer\GAL4^Mef2.PU

(Yun et al., 2014)

Pink1⁵ has mitochondrion phenotype, suppressible | partially by Scer\GAL4^Mef2.PR/park^UAS.cGa

(Deng et al., 2008)

Pink1⁵ has mitochondrion phenotype, suppressible by Scer\GAL4^Mef2.PR/Marf^RNAi.CDS.UAS

(Deng et al., 2008)

Pink1⁵ has mitochondrial crista phenotype, suppressible by Scer\GAL4^Mef2.PR/Marf^RNAi.CDS.UAS

(Deng et al., 2008)

Pink1⁵ has mitochondrion phenotype, suppressible by Marf^RNAi.UTR.UAS/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has mitochondrial crista phenotype, suppressible by Marf^RNAi.UTR.UAS/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has mitochondrion phenotype, suppressible by Opa1^RNAi.CDS.UAS/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has mitochondrion phenotype, suppressible by Drp1^UAS.cDa/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has wing phenotype, suppressible by Scer\GAL4^Mef2.PR/Marf^RNAi.CDS.UAS

(Deng et al., 2008)

Pink1⁵ has wing phenotype, suppressible by Marf^RNAi.UTR.UAS/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has indirect flight muscle cell phenotype, suppressible by Scer\GAL4^Mef2.PR/Marf^RNAi.CDS.UAS

(Deng et al., 2008)

Pink1⁵ has indirect flight muscle cell phenotype, suppressible by Marf^RNAi.UTR.UAS/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has wing phenotype, suppressible by Drp1^UAS.cDa/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has indirect flight muscle cell phenotype, suppressible by Drp1^UAS.cDa/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ has Nebenkern phenotype, suppressible | partially by park^βTub85D.PC

(Clark et al., 2006)

Pink1⁵ has mitochondrial crista & indirect flight muscle phenotype, suppressible | partially by Scer\GAL4^how-24B/park^UAS.cGa

(Clark et al., 2006)

Pink1⁵ has Nebenkern phenotype, suppressible | partially by Hsap\PINK1^βTub85D.PC

(Clark et al., 2006)

NOT suppressed by

Statement

Reference

Pink1⁵ has mitochondrion | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista junction | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\PINK1^{ΔMTS.UAS.Tag:FLAG}

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/park^UAS.cGa

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/park^UAS.cGa

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/park^UAS.cGa

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Mul1^UAS.cYa

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Mul1^UAS.cYa

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Mul1^UAS.cYa

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Drp1^UAS.cUa

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Drp1^UAS.cUa

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/Drp1^UAS.cUa

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/ND-42^UAS.cBa

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/ND-42^UAS.cBa

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/ND-42^UAS.cBa

(Tsai et al., 2018)

Pink1⁵ has mitochondrion | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/sicily^UAS.cZa

(Tsai et al., 2018)

Pink1⁵ has mitochondrial crista | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/sicily^UAS.cZa

(Tsai et al., 2018)

Pink1⁵ has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^da.PU/sicily^UAS.cZa

(Tsai et al., 2018)

Pink1⁵ has indirect flight muscle cell phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Mul1^LD.UAS

(Yun et al., 2014)

Pink1⁵ has adult thorax | dorsal phenotype, non-suppressible by Scer\GAL4^Mef2.PU/Mul1^LD.UAS

(Yun et al., 2014)

Pink1⁵ has spermatid phenotype, non-suppressible by HtrA2^βTub85D.PY

(Yun et al., 2008)

Pink1⁵ has Nebenkern phenotype, non-suppressible by HtrA2^βTub85D.PY

(Yun et al., 2008)

Pink1⁵ has mitochondrial derivative phenotype, non-suppressible by HtrA2^βTub85D.PY

(Yun et al., 2008)

NOT Enhancer of

Statement

Reference

Pink1⁵ is a non-enhancer of adult thorax | dorsal phenotype of park²⁵

(Yun et al., 2014)

Suppressor of

Statement

Reference

Pink1⁵ is a suppressor | partially of mitochondrion | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

Pink1⁵ is a suppressor | partially of axon | somatic clone | adult stage phenotype of gfzf⁵⁴¹

(Smith et al., 2019)

NOT Suppressor of

Statement

Reference

Pink1⁵/Pink1⁵ is a non-suppressor of eye | heat sensitive phenotype of HtrA2^UAS.cYa, Scer\GAL4^GMR.PF

(Yun et al., 2008)

Other

Statement

Reference

Mul1^A6, Pink1⁵ has mitochondrion phenotype

(Yun et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Mul1^Scer\UAS.cYa under the control of Scer\GAL4^ple.PF suppresses the abnormal clumping of mitochondria seen in the PPL1 dopaminergic neurons of Pink1⁵ adults.

Expression of Mul1^Scer\UAS.cYa under the control of Scer\GAL4^Mef2.PU suppresses almost all the defects seen in the indirect flight muscles of Pink1⁵ adults and the thoracic indentation phenotype is also suppressed.

Expression of Mul1^LD.Scer\UAS under the control of Scer\GAL4^Mef2.PU does not suppress the abnormal clumping of mitochondria or muscle cell death seen in the indirect flight muscles of Pink1⁵ adults. The thoracic indentation seen in Pink1⁵ adults is also not suppressed.

The degree of thoracic indentation seen in park²⁵ Pink1⁵ double mutants is the same as that seen in either single mutant. The mitochondrial morphology in the indirect flight muscles of the double mutants is similar to that seen in the single mutants.

The degree of thoracic indentation seen in Pink1⁵ Mul1^A6 is much more severe than that seen in Pink1⁵ single mutants.

The indirect flight muscles of Pink1⁵ Mul1^A6 mutants have highly elongated and interconnected mitochondria.

(Yun et al., 2014)

Pink1⁵/Y ; fzo¹/Df(3R)P2O double mutants have nebenkern and mitochondrial derivative phenotypes similar to those of Pink1⁵/Y single mutants.

Expression of park^Scer\UAS.cGa under the control of Scer\GAL4^Mef2.PR partially rescues the defects in mitochondrial morphology that are seen in the indirect flight muscles of Pink1⁵ mutants.

Expression of either Marf^{miRNA.CDS.Scer\UAS} or Marf^{miRNA.UTR.Scer\UAS} under the control of Scer\GAL4^Mef2.PR suppresses the defects in mitochondrial morphology that are seen in the indirect flight muscles of Pink1⁵ mutants. The defects in wing posture and indirect flight muscle degeneration phenotypes are also suppressed.

Expression of Drp1^Scer\UAS.cDa under the control of Scer\GAL4^Mef2.PR suppresses the defects in mitochondrial morphology that are seen in the indirect flight muscles of Pink1⁵ mutants. The defects in wing posture and indirect flight muscle degeneration phenotypes are also suppressed.

Expression of opa1-like^{miRNA.CDS.Scer\UAS} under the control of Scer\GAL4^Mef2.PR suppresses the defects in mitochondrial morphology that are seen in the indirect flight muscles of Pink1⁵ mutants.

(Deng et al., 2008)

Homozygous Pink1⁵ fails to suppress the rough eye phenotype seen when HtrA2^Scer\UAS.cYa is expressed under the control of Scer\GAL4^GMR.PF at 29[o]C.

Expression of HtrA2^βTub85D.PY fails to suppress the mitochondrial morphology defects seen in Pink1⁵ mutant spermatids. The spherical "onion stage" nebenkern contain vacuoles, and only one mitochondrial derivative is seen in "leaf blade stage" elongating spermatids. As in Pink1⁵ mutants alone the flies are sterile.

A HtrA2^NSO/Df(3R)ED5644 mutant background does not enhance the mitochondrial morphology defects seen in Pink1⁵ mutant spermatids.

Expression of HtrA2^{dsRNA.Scer\UAS.cYa} under the control of Scer\GAL4^Mef2.PR does not enhance the mitochondrial morphology defects seen in Pink1⁵ mutant indirect flight muscles.

(Yun et al., 2008)

The indirect flight muscles of 2 day old Pink1⁵ adults that are also expressing park^Scer\UAS.cGa under the control of Scer\GAL4^how-24B have some mitochondria with normal densely packed cristae and some with fragmented cristae, in contrast to 2 day old Pink1⁵ single mutants, where the mitochondria of the indirect flight muscles have fragmented cristae.

(Clark et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pink1⁵ is rescued by Pink1^UAS.cCa/Scer\GAL4^Mef2.PR

(Deng et al., 2008)

Pink1⁵ is rescued by Pink1^+tCa

(Yun et al., 2008)

Pink1⁵ is rescued by Pink1^UAS.cCa

(Yun et al., 2008)

Pink1⁵ is rescued by Pink1^βTub85D.PC

(Yun et al., 2008)

Pink1⁵ is rescued by Pink1^+tCa

(Clark et al., 2006)

Not rescued by

Pink1⁵ is not rescued by Pink1^G426D

(Yun et al., 2008)

Comments

Expression of Pink1^Scer\UAS.cCa under the control of Scer\GAL4^Mef2.PR completely rescues the defects in mitochondrial morphology that are seen in the indirect flight muscles of Pink1⁵ mutants.

(Deng et al., 2008)

Expression of Pink1^βTub85D.PC rescues the mitochondrial morphology defects in Pink1⁵ mutant spermatids. The spherical "onion stage" nebenkern no longer contain vacuoles and, as in wild type, two mitochondrial derivatives are seen in "leaf blade stage" elongating spermatids.

Expression of Pink1^Scer\UAS.cCa under the control of Scer\GAL4^Mef2.PR rescues the mitochondria morphology defects seen in Pink1⁵ mutant indirect flight muscles.

Expression of Pink1^+tCa rescues the male sterility, indirect flight muscle degeneration and mitochondrial defects seen in Pink1⁵ mutant flies.

Expression of Pink1^G426D fails to rescue the male sterility, indirect flight muscle degeneration and mitochondrial defects seen in Pink1⁵ mutant flies.

(Yun et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51649

w^* Pink1⁵/FM7i, P{ActGFP}JMR3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

PINK1⁵

(Wang et al., 2023, Liu et al., 2022, Yang et al., 2022, Mori et al., 2019, Course et al., 2018, Tsai et al., 2018, Zhang et al., 2017, West et al., 2015, Yun et al., 2014)

PINK⁵

(Tsai et al., 2014)

Pink1⁵

(Cheramangalam et al., 2023, Paradis et al., 2022, Smith et al., 2019, Myers et al., 2018, Cao et al., 2017, Liu et al., 2015, Yun et al., 2008)

pink1⁵

(Moehlman et al., 2023, Deng et al., 2008, Clark et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (20)

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