FlyBase Allele Report: Dmel\Mul1[UAS.cYa]

General Information

Symbol

Dmel\Mul1^UAS.cYa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Yun

FlyBase ID

FBal0301077

Feature type

allele

Associated gene

Dmel\Mul1

Associated Insertion(s)

Carried in Construct

P{UAS-Mul1.Y}

Also Known As

UAS-MUL1

Key Links

Transgenic product class

cDNA

(Yun et al., 2014)

wild_type

(Yun et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Yun et al., 2014)

wild_type

(Yun et al., 2014)

Mutagen

in vitro construct

(Yun et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-Mul1.Y}

Cytology

Description

UASt regulatory sequences drive expression of the Mul1 AT15655 cDNA.

(Yun et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mul1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1⁵

(Yun et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

indirect flight muscle cell, with Scer\GAL4^Mef2.PU

(Yun et al., 2014)

mitochondrion, with Scer\GAL4^Mef2.PU

(Yun et al., 2014)

Detailed Description

Statement

Reference

Flies expressing Mul1^Scer\UAS.cYa under the control of Scer\GAL4^Mef2.PU have significantly smaller mitochondria in the indirect flight muscles compared to wild type.

Expression of Mul1^Scer\UAS.cYa under the control of Scer\GAL4^RapGAP1-OK6 results in an increase in mitochondrial number and a reduction in mitochondrial size in the larval salivary glands compared to wild type.

(Yun et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Mul1^UAS.cYa, Scer\GAL4^Act5C.PI is a non-enhancer of decreased rate of adult locomotory behavior phenotype of Scer\GAL4^Act5C.PI, Usp30^UAS.cUa

(Sanchez-Martinez et al., 2023)

Suppressor of

Statement

Reference

Mul1^UAS.cYa/Scer\GAL4^Mef2.PU is a suppressor of visible phenotype of Pink1⁵

(Yun et al., 2014)

Mul1^UAS.cYa/Scer\GAL4^Mef2.PU is a suppressor of increased cell death phenotype of Pink1⁵

(Yun et al., 2014)

NOT Suppressor of

Statement

Reference

Mul1^UAS.cYa, Scer\GAL4^Act5C.PI is a non-suppressor of decreased rate of adult locomotory behavior phenotype of Scer\GAL4^Act5C.PI, Usp30^UAS.cUa

(Sanchez-Martinez et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mul1^UAS.cYa, Scer\GAL4^fln.IFM is a suppressor of mitochondrion phenotype of Marf^UAS.cYa, Scer\GAL4^fln.IFM

(Yun et al., 2014)

Scer\GAL4^ple.PF/Mul1^UAS.cYa is a suppressor of dopaminergic PPL1 neuron phenotype of Pink1⁵

(Yun et al., 2014)

Scer\GAL4^ple.PF/Mul1^UAS.cYa is a suppressor of mitochondrion phenotype of Pink1⁵

(Yun et al., 2014)

Mul1^UAS.cYa/Scer\GAL4^Mef2.PU is a suppressor of mitochondrion phenotype of Pink1⁵

(Yun et al., 2014)

Mul1^UAS.cYa/Scer\GAL4^Mef2.PU is a suppressor of indirect flight muscle cell phenotype of Pink1⁵

(Yun et al., 2014)

Mul1^UAS.cYa/Scer\GAL4^Mef2.PU is a suppressor of adult thorax | dorsal phenotype of Pink1⁵

(Yun et al., 2014)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Mul1^UAS.cYa is a non-suppressor of mitochondrion | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mul1^UAS.cYa is a non-suppressor of mitochondrial crista | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Scer\GAL4^da.PU/Mul1^UAS.cYa is a non-suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of Pink1⁵

(Tsai et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Mul1^Scer\UAS.cYa under the control of Scer\GAL4^ple.PF suppresses the abnormal clumping of mitochondria seen in the PPL1 dopaminergic neurons of Pink1⁵ adults.

Expression of Mul1^Scer\UAS.cYa under the control of Scer\GAL4^Mef2.PU suppresses almost all the defects seen in the indirect flight muscles of Pink1⁵ adults and the thoracic indentation phenotype is also suppressed.

Co-expression of Mul1^Scer\UAS.cYa suppresses the mitochondrial clumping which is seen in the indirect flight muscles of flies expressing Marf^Scer\UAS.cYa under the control of Scer\GAL4^fln.IFM.

(Yun et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mul1^Scer\UAS.cYa

Mul1^UAS.cYa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Yun

Secondary FlyBase IDs

References (4)

Report Sections

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