FlyBase Allele Report: Dmel\Ntan1[UAS.cZa]

General Information

Symbol

Dmel\Ntan1^UAS.cZa

Species

D. melanogaster

Name

UAS construct of Zulbahar

FlyBase ID

FBal0342077

Feature type

allele

Associated gene

Dmel\Ntan1

Associated Insertion(s)

Carried in Construct

M{UAS-Ntan1.Z}

Key Links

Transgenic product class

cDNA

(Zülbahar et al., 2018)

wild_type

(Zülbahar et al., 2018)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zülbahar et al., 2018)

wild_type

(Zülbahar et al., 2018)

Mutagen

in vitro construct

(Zülbahar et al., 2018)

Progenitor genotype

Carried in construct

M{UAS-Ntan1.Z}

Cytology

Description

UASt regulates expression of a Ntan1 cDNA.

(Zülbahar et al., 2018)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ntan1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval glial cell | larval stage, with Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

eye disc, with Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

PNS glial cell | third instar larval stage, with Df(2R)Ntan^Δ, Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

PNS glial cell | third instar larval stage, with Scer\GAL4^repo.PU

(Zülbahar et al., 2018)

Detailed Description

Statement

Reference

In a wild-type or Df(2R)Ntan^Δ background, third instar larvae expressing Ntan1^UAS.cZa under the control of Scer\GAL4^repo.PU, induces a decreased number of glial cell nuclei along peripheral nerves, as compared to wild-type controls; in a wild-type background, expression under the control of Scer\GAL4^46F yields the same outcome; and the expression under the control of Scer\GAL4^repo.PU leads to a decrease in the number of perineurial glial cells in the eye imaginal disc and in the central nervous system, as compared to controls. However, expression under the control of Scer\GAL4^insc-Mz1407 does not seem to interfere with the larval brain size, and the expression under the control of Scer\GAL4^en-e16E does not lead to any obvious change in the number of cells in the wing disc posterior compartment, as compared to controls.