Amino acid replacement: C136Y.
G18135091A
C136Y | ari-1-PA; C136Y | ari-1-PB; C136Y | ari-1-PC; C136Y | ari-1-PD; C136Y | ari-1-PE; C136Y | ari-1-PF
C136Y
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
The few ari-1A homozygous and ari-1A/ari-1D transheterozygous escapers show a severely decreased lifespan as compared to controls; ari-1A homozygotes rescued to adulthood by a copy Dp(1;3)DC342 or by the expression of ari-1UAS.cFa under the control of Scer\GAL4da.G32 also show decreases (although less severe) in lifespan; ari-1A escapers display thin macro and microchaeta.
ari-1A homozygous clones in mosaic individuals can reach large sizes in various tissues; eye clones show synaptic transmission defects (i.e. reduced ON transients but normal amplitude in electroretinograms).
Body wall muscles in ari-1A/ari-1B transheterozygous, ari-1A/Df(1)BSC352 transheterozygous and ari-1A homo/heterozygous third instar larvae frequently show nuclei clustering together or in contact with each other, instead of the typically even spaced in controls; ari-1A homozygous larvae, however, do not show significant changes in myonuclear number. In ari-1A homozygous and ari-1A/ari-1D transheterozygous backgrounds, these nuclei exhibit a smaller size and an irregular shape (uneven nuclear envelope), are displaced from the cell membrane, and do not seem to be surrounded by a microtubule cytoskeletal network. ari-1A/ari-1B transheterozygous adult indirect flight muscles and ari-1A homozygous larval body wall muscles do not display obvious mitochondrial morphology defects.
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, enhanceable by parkΔ21/parkΔ21
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, suppressible by Dp(1;Y)W39/+
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, suppressible by Dp(1;3)DC342/+
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, suppressible | partially by Scer\GAL4da.G32/parkUAS.cGa
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, suppressible by Hsap\ARIH1UAS.cFa/Scer\GAL4da.G32
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, suppressible | partially by Hsap\ARIH1R171stop.UAS/Scer\GAL4da.G32
ari-1A has short lived | recessive phenotype, suppressible by Hsap\ARIH1UAS.cFa/Scer\GAL4da.G32
ari-1A has short lived | recessive phenotype, non-suppressible by Hsap\ARIH1R171stop.UAS/Scer\GAL4da.G32
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, non-suppressible by Scer\GAL4da.G32/Hsap\ARIH1E15Q.UAS
ari-1A has lethal - all die before end of pupal stage | recessive phenotype, non-suppressible by Hsap\ARIH1E44G.UAS/Scer\GAL4da.G32
ari-1A, parkf01950/park[+] has abnormal size | third instar larval stage phenotype
ari-1A, parkΔ21/park[+] has abnormal size | third instar larval stage phenotype
Scer\GAL4da.G32, ari-1A, parkUAS.cGa has short lived phenotype
ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible | partially by Dp(1;3)DC342/+
ari-1A has nucleus | third instar larval stage phenotype, suppressible | partially by Dp(1;3)DC342/+
ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by Scer\GAL4da.G32/parkUAS.cGa
ari-1A has nucleus | third instar larval stage phenotype, suppressible by Scer\GAL4da.G32/parkUAS.cGa
ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, suppressible by Hsap\ARIH1UAS.cFa/Scer\GAL4da.G32
ari-1A has nucleus | third instar larval stage phenotype, suppressible by Hsap\ARIH1UAS.cFa/Scer\GAL4da.G32
ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by ari-2UAS.Tag:V5/Scer\GAL4da.G32
ari-1A has nucleus | third instar larval stage phenotype, non-suppressible by ari-2UAS.Tag:V5/Scer\GAL4da.G32
ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Hsap\ARIH1R171stop.UAS/Scer\GAL4da.G32
ari-1A has nucleus | third instar larval stage phenotype, non-suppressible by Hsap\ARIH1R171stop.UAS/Scer\GAL4da.G32
FBal0042573:, ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Hsap\ARIH1E15Q.UAS, Scer\GAL4da.G32/Scer\GAL4da.G32
FBal0042573:, ari-1A has nucleus | third instar larval stage phenotype, non-suppressible by Hsap\ARIH1E15Q.UAS, Scer\GAL4da.G32/Scer\GAL4da.G32
ari-1A has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype, non-suppressible by Hsap\ARIH1E44G.UAS/Scer\GAL4da.G32
ari-1A has nucleus | third instar larval stage phenotype, non-suppressible by Hsap\ARIH1E44G.UAS/Scer\GAL4da.G32
ari-1A, parkf01950/park[+] has nucleus | third instar larval stage phenotype
ari-1A, parkf01950/park[+] has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype
ari-1A, parkΔ21/park[+] has nucleus | third instar larval stage phenotype
ari-1A, parkΔ21/park[+] has embryonic/larval hypodermal muscle cell | third instar larval stage phenotype
Body wall muscles in ari-1A/+,park[Δ21]/+, ari-1A/Y,park[Δ21]/+, ari-1A/+,parkf01950/+ or ari-1A/Y,parkf01950/+ third instar larvae frequently show nuclei clustering together or in contact with each other, instead of the typically even spaced in controls; these nuclei also exhibit a smaller size and an irregular shape (uneven nuclear envelope).
ari-1A/+,park[13]/+ body wall muscles do not display obvious mitochondrial morphology defects.
ari-1A is rescued by ari-1UAS.cFa/Scer\GAL4da.G32
ari-1A is partially rescued by ari-1UAS.cFa/Scer\GAL4Mef2.PR
ari-1A is not rescued by ari-1UAS.cFa/Scer\GAL4C57