Gene Group: NON-PEPTIDASE HOMOLOGS

General Information

Name

NON-PEPTIDASE HOMOLOGS

Species

D. melanogaster

Symbol

NPH

FlyBase ID

FBgg0001481

Date last reviewed

2020-06-15

Number of members

179

Description

A protein of known sequence that can be placed in a peptidase family but lacks one or more of the expected catalytic residues is described as a 'non-peptidase homolog'. Some non-peptidase homologs are enzymes of other kinds. (Adapted from FBrf0239469.)

Notes on Group

Source Material

The NON-PEPTIDASE HOMOLOGS Gene Group has been compiled using the following publication(s): Li et al., 2022, Meyer et al., 2021, Jiang, 2019.3.1, Laurinyecz et al., 2019, Metwally et al., 2019, Cao and Jiang, 2018, Meyer et al., 2018.7.18, Sitnik et al., 2014, Clague et al., 2013, Crosby et al., 2013.1.30, Adolphsen et al., 2012, Dorus et al., 2011, Belote and Zhong, 2009, Bland et al., 2008, Chihara et al., 2005, Friedrich et al., 2004, Kocks et al., 2003, Ma et al., 2002, Urban et al., 2002, Coates et al., 2000, Guichard et al., 2000, Wasserman et al., 2000, and Rawlings and Barrett, 1996- .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

Cellular Component

Related Gene Groups

Parent group(s)

PSEUDOENZYMES

Component group(s)

CYSTEINE-TYPE NON-PEPTIDASE HOMOLOGS

METALLO-TYPE NON-PEPTIDASE HOMOLOGS

SERINE-TYPE NON-PEPTIDASE HOMOLOGS

THREONINE-TYPE NON-PEPTIDASE HOMOLOGS

Other related group(s)

PEPTIDASES

Members (179)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ANGIOTENSIN-CONVERTING PSEUDOENZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ance-2

(Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance-3

DS00180.5, BG:DS00180.5

(Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance-4

(Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance-5

(Coates et al., 2000, Rawlings and Barrett, 1996-)

C1 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6337

(Kocks et al., 2003, Rawlings and Barrett, 1996-)

CG6357

(Kocks et al., 2003)

CG13423

(Rawlings and Barrett, 1996-)

Swim

Secreted Wg-interacting molecule

(Kocks et al., 2003, Rawlings and Barrett, 1996-)

C19 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

echinus

EG:EG0002.3

(FlyBase, 2017-, Clague et al., 2013, Rawlings and Barrett, 1996-)

PAN2

Poly(A)-binding protein-dependent poly(A) ribonuclease 2

(FlyBase, 2017-, Clague et al., 2013, Rawlings and Barrett, 1996-)

Usp39

Ubiquitin specific protease 39

(FlyBase, 2017-, Clague et al., 2013, Rawlings and Barrett, 1996-)

C26 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

rudimentary

Su(b), CAD, fs(1)M34

(Rawlings and Barrett, 1996-)

C48 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1503

(Rawlings and Barrett, 1996-)

C110 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Hil

Hillarin

(Rawlings and Barrett, 1996-)

CALPAIN NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CalpC

Calpain C

(Metwally et al., 2019, Friedrich et al., 2004, Rawlings and Barrett, 1996-)

M1 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2111

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG4467

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG6071

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG9806

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG40470

(Li et al., 2022, Rawlings and Barrett, 1996-)

Taf2

TBP-associated factor 2

dTAF_II150, TAF_II150, Taf150, TFIID, TAFII150

(Rawlings and Barrett, 1996-)

M3 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG11771

(Rawlings and Barrett, 1996-)

M12 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

mmd

mind-meld

CT26192

(Rawlings and Barrett, 1996-)

M14 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8945

(Rawlings and Barrett, 1996-)

CG42264

(Rawlings and Barrett, 1996-)

M16 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

UQCR-C2

Ubiquinol-cytochrome c reductase core protein 2

dUQCRC2, BEST:GH10978

(Rawlings and Barrett, 1996-)

M19 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5282

(Rawlings and Barrett, 1996-)

M24 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6225

(Rawlings and Barrett, 1996-)

CG10576

(Rawlings and Barrett, 1996-)

CG32454

(Rawlings and Barrett, 1996-)

dre4

Spt16, dSPT16, l(3)dre4, l(3)62Bg

(Rawlings and Barrett, 1996-)

M48 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7573

(Adolphsen et al., 2012, Rawlings and Barrett, 1996-)

M67 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CSN6

COP9 signalosome subunit 6

Dch6

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Prp8

pre-mRNA processing factor 8

(FlyBase, 2017-)

Rpn8

Regulatory particle non-ATPase 8

Mov34, p39B, l(2)k08003

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

NEPRILYSIN-LIKE METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

frma

fra mauro

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

goe

gone early

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl3

Neprilysin-like 3

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl4

Neprilysin-like 4

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl5

Neprilysin-like 5

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl6

Neprilysin-like 6

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl7

Neprilysin-like 7

(Meyer et al., 2021, Meyer et al., 2018.7.18, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl8

Neprilysin-like 8

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl9

Neprilysin-like 9

(Meyer et al., 2021, Meyer et al., 2018.7.18, Rawlings and Barrett, 1996-)

Nepl10

Neprilysin-like 10

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl11

Neprilysin-like 11

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl12

Neprilysin-like 12

(Meyer et al., 2021, Meyer et al., 2018.7.18, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl13

Neprilysin-like 13

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl14

Neprilysin-like 14

(Meyer et al., 2021, Meyer et al., 2018.7.18, Rawlings and Barrett, 1996-)

Nepl15

Neprilysin-like 15

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl16

Neprilysin-like 16

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl17

Neprilysin-like 17

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl18

Neprilysin-like 18

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl19

Neprilysin-like 19

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl20

Neprilysin-like 20

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl21

Neprilysin-like 21

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

PROTEASOME ALPHA SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Prosα1

Proteasome α1 subunit

α1, Prosalpha6, Proteasome alpha6 subunit, Proteasome α6 subunit, alpha1

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα1R

Proteasome α1 subunit-related

(Crosby et al., 2013.1.30)

Prosα2

Proteasome α2 subunit

Pros25, α2, PROS Dm25, Su(DTS)-1, Proteasome 25kD subunit

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα3

Proteasome α3 subunit

Pros29, α3, Proteasome 29kD subunit

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα3T

Proteasome α3 subunit, Testis-specific

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα4

Proteasome α4 subunit

Pros28.1, α4, Proteasome 28kD subunit 1, PROS-Dm28.1, α4_dm

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα4T1

Proteasome α4 subunit, Testis-specific 1

Pros28.1A, α4t1_dm

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα4T2

Proteasome α4 subunit, Testis-specific 2

Pros28.1B, α4t2_dm

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα5

Proteasome α5 subunit

ProsMA5, α5, PSMA5, alpha5

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα6

Proteasome α6 subunit

Pros35, α6, anon-SAGE:Wang-116, PROS-35, Proteasome 35kD subunit

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα6T

Proteasome α6 subunit, Testis-specific

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα7

Proteasome α7 subunit

α7, CPα7, alpha7

(Belote and Zhong, 2009, Ma et al., 2002)

PROTEASOME NON-CATALYTIC BETA SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Prosβ3

Proteasome β3 subunit

β3

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ4

Proteasome β4 subunit

β4

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ4R1

Proteasome β4 subunit-related 1

(Belote and Zhong, 2009, Ma et al., 2002)

Prosβ4R2

Proteasome β4 subunit-related 2

(Belote and Zhong, 2009, Ma et al., 2002)

Prosβ6

Proteasome β6 subunit

Pros26, DTS5, l(3)73Ai, β6, DTS-5

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ7

Proteasome β7 subunit

Prosβ4, β7

(Belote and Zhong, 2009, Ma et al., 2002)

RHOMBOID PSEUDOPROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

rho-5

rhomboid-5

iRhom

(Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000)

S1A NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aqrs

aquarius

(Cao and Jiang, 2018)

CG1632

SPH198

(Cao and Jiang, 2018)

CG3088

SPH188

(Cao and Jiang, 2018)

CG3117

(Cao and Jiang, 2018)

CG3505

(Cao and Jiang, 2018)

CG4259

SPH173

(Cao and Jiang, 2018)

CG4271

SPH164

(Cao and Jiang, 2018)

CG4477

(Cao and Jiang, 2018)

CG4650

SPH197

(Cao and Jiang, 2018)

CG4653

SPH179

(Cao and Jiang, 2018)

CG4793

BG:DS07486.3

(Cao and Jiang, 2018)

CG4998

(Cao and Jiang, 2018)

CG6067

(Cao and Jiang, 2018)

CG8586

(Cao and Jiang, 2018)

CG8738

(Cao and Jiang, 2018)

CG9377

(Cao and Jiang, 2018)

CG9672

SPH161

(Cao and Jiang, 2018)

CG9673

SPH81

(Cao and Jiang, 2018)

CG9897

SPH195

(Cao and Jiang, 2018)

CG9997

(Cao and Jiang, 2018)

CG13318

(Cao and Jiang, 2018)

CG13527

SPH182

(Cao and Jiang, 2018)

CG14088

SPH199

(Cao and Jiang, 2018)

CG14990

SPH97

(Cao and Jiang, 2018)

CG15046

(Jiang, 2019.3.1)

CG15873

SPH184

(Cao and Jiang, 2018)

CG17242

SPH187, anon-SAGE:Wang-110

(Cao and Jiang, 2018)

CG17572

(Cao and Jiang, 2018)

CG18223

SPH200

(Cao and Jiang, 2018)

CG18420

BG:DS06874.6, SPH111

(Cao and Jiang, 2018)

CG18477

BG:DS07108.1

(Cao and Jiang, 2018)

CG18478

BG:DS07108.5, DS07108.5, SPH157

(Cao and Jiang, 2018)

CG18557

(Cao and Jiang, 2018)

CG18563

(Cao and Jiang, 2018)

CG30323

SPH206

(Cao and Jiang, 2018)

CG31199

(Cao and Jiang, 2018)

CG31200

(Cao and Jiang, 2018)

CG31205

(Cao and Jiang, 2018)

CG31266

(Cao and Jiang, 2018)

CG31267

(Cao and Jiang, 2018)

CG31326

SPH144

(Cao and Jiang, 2018)

CG31780

(Cao and Jiang, 2018)

CG31827

(Cao and Jiang, 2018)

CG32833

(Cao and Jiang, 2018)

CG32834

(Cao and Jiang, 2018)

CG33127

(Cao and Jiang, 2018)

CG33225

(Cao and Jiang, 2018)

CG33460

(Cao and Jiang, 2018)

CG33465

(Cao and Jiang, 2018)

CG34129

(Cao and Jiang, 2018)

CG34130

(Cao and Jiang, 2018)

CG34171

(Cao and Jiang, 2018)

CG34295

(Cao and Jiang, 2018)

CG34436

(Cao and Jiang, 2018)

CG34437

(Cao and Jiang, 2018)

CG42694

(Cao and Jiang, 2018)

CG43124

(Cao and Jiang, 2018)

CG43125

(Cao and Jiang, 2018)

intr

intrepid

SPH202

(Cao and Jiang, 2018)

κTry

SPH109

(Cao and Jiang, 2018)

mas

masquerade

(Cao and Jiang, 2018)

scaf

scarface

(Cao and Jiang, 2018)

Sph35

Serine protease homolog 35

cSPH35

(Cao and Jiang, 2018)

SPH93

Serine protease homolog 93

(Cao and Jiang, 2018)

Sph242

Serine protease homolog 242

cSPH242

(Cao and Jiang, 2018)

sphe

spheroide

SPH114

(Cao and Jiang, 2018)

sphinx1

SPH194

(Cao and Jiang, 2018)

sphinx2

SPH194

(Cao and Jiang, 2018)

S9 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ace

Acetylcholine esterase

AChE, acetylcholinesterase, DmAChE

(Rawlings and Barrett, 1996-)

α-Est1

α-Esterase-1

αE1, A, Est1, DmαE1, fragment A

(Rawlings and Barrett, 1996-)

α-Est3

α-Esterase-3

αE3, DmαE3, α-Ests

(Rawlings and Barrett, 1996-)

α-Est5

α-Esterase-5

αE5, DmαE5, Est-C

(Rawlings and Barrett, 1996-)

α-Est8

α-Esterase-8

αE8, Est8, DmαE8

(Rawlings and Barrett, 1996-)

α-Est9

α-Esterase-9

αE9, DmαE9, Dm_3R:18691

(Rawlings and Barrett, 1996-)

CG4382

(Rawlings and Barrett, 1996-)

CG5397

(Rawlings and Barrett, 1996-)

CG12869

(Rawlings and Barrett, 1996-)

CG45002

(FlyBase, 2017-, Chihara et al., 2005, Rawlings and Barrett, 1996-)

Est-6

Esterase 6

Est6, Est-D, Est

(Rawlings and Barrett, 1996-)

Gli

Gliotactin

l(2)35Dg, l(2)br45, BG:DS09217.3

(Rawlings and Barrett, 1996-)

Glt

Glutactin

(Rawlings and Barrett, 1996-)

Jhedup

Juvenile hormone esterase duplication

(Rawlings and Barrett, 1996-)

Nlg2

Neuroligin 2

neuroligin, dnlg2, dnl2

(Rawlings and Barrett, 1996-)

Nrt

Neurotactin

dab, BP106, disabled, Neur

(Rawlings and Barrett, 1996-)

S33 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2059

(Rawlings and Barrett, 1996-)

CG2082

BcDNA:GH02439

(Rawlings and Barrett, 1996-)

CG14717

anon-SAGE:Wang-126

(Rawlings and Barrett, 1996-)

Jheh1

Juvenile hormone epoxide hydrolase 1

Jheh, JH, EH, epoxide hydrolase

(Rawlings and Barrett, 1996-)

Jheh2

Juvenile hormone epoxide hydrolase 2

epoxide hydrolase, EH

(Rawlings and Barrett, 1996-)

Jheh3

Juvenile hormone epoxide hydrolase 3

EH, epoxide hydrolase

(Rawlings and Barrett, 1996-)

S60 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Tsf1

Transferrin 1

Transferrin, lincRNA.S9601

(Rawlings and Barrett, 1996-)

Tsf2

Transferrin 2

Melanotransferrin, MTf

(Rawlings and Barrett, 1996-)

Tsf3

Transferrin 3

(Rawlings and Barrett, 1996-)

S81 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6421

EG:EG0003.8

(Rawlings and Barrett, 1996-)

CG6426

n(2)k04810

(Rawlings and Barrett, 1996-)

CG6429

(Rawlings and Barrett, 1996-)

SPERM LEUCYL AMINOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

loopin-1

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap1

Sperm-Leucylaminopeptidase 1

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap2

Sperm-Leucylaminopeptidase 2

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap3

Sperm-Leucylaminopeptidase 3

lincRNA.S4635

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap4

Sperm-Leucylaminopeptidase 4

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap5

Sperm-Leucylaminopeptidase 5

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap7

Sperm-Leucylaminopeptidase 7

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap8

Sperm-Leucylaminopeptidase 8

(Laurinyecz et al., 2019, Dorus et al., 2011)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

NPH

NON-PEPTIDASE HOMOLOGS

Secondary FlyBase ID(s)

References (25)

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