Combined analysis of the MEROPS database (https://www.ebi.ac.uk/merops/), several published papers (FBrf0224452, FBrf0214506, FBrf0204608, FBrf0134455) and InterPro annotations (Peptidase M13 family", IPR000718) in FlyBase identifies a total of 28 D. melanogaster genes encoding M13 class metalloendopeptidases. 7 of these contain all four of the conserved motifs identified as important for catalytic activity in vertebrate neprilysins - these are classed as 'Neprilysins' and given a 'Nep' prefix, and include the previously named genes Nep1, Nep2, Nep3, Nep4 and Nep5. The other 21 genes encode proteins with significant similarity to Neprilysins but lack one of more of the catalytically important motifs - these may be catalytically inactive, and are classed as 'Neprilysin-like' and given a 'Nepl' prefix. The names of 'frma' (CG3239) and 'goe' (CG9634) have not been changed, but 'Nepl1' and 'Nepl2' are added as respective synonyms to recognize the fact they were the first and second Nep-like genes to be characterized. The remaining Nepl genes are given a numerical suffix, incremented based on their genomic location. See associated files for additional information and analysis. The full list of Nep and Nepl genes: CG# SYMBOL CG5905 Nep1 CG9761 Nep2 CG9565 Nep3 CG4058 Nep4 CG6265 Nep5 CG3775 Nep6 CG5527 Nep7 CG3239 frma (Nepl1) CG9634 goe (Nepl2) Nepl3 CG31918 Nepl4 CG9505 Nepl5 CG9507 Nepl6 CG42370 Nepl7 CG15485 Nepl8 CG4580 Nepl9 CG13283 Nepl10 CG8550 Nepl11 CG9780 Nepl12 CG8358 Nepl13 CG4725 Nepl14 CG4723 Nepl15 CG4721 Nepl16 CG13650 Nepl17 CG14529 Nepl18 CG14528 Nepl19 CG14523 Nepl20 CG14527 Nepl21 CG14526
