FlyBase Gene Report: Dmel\Nep1

General Information

Symbol

Dmel\Nep1

Species

D. melanogaster

Name

Neprilysin 1

Annotation Symbol

CG5905

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029843

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Neprilysin 1 (Nep1) encodes a plasma membrane bound metallopeptidase considered to cleave and thus inactivate signaling peptides in the extracellular space. It contributes to female and male fertility. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dNEP1

Key Links

Genomic Location

Cytogenetic map

5D4-5D5

Sequence location

X:6,091,205..6,103,971 [+]

Recombination map

1-15

RefSeq locus

NC_004354 REGION:6091205..6103971

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR018497

(InterPro Project Members, 2004-)

enables metallopeptidase activity

inferred from sequence model

(Sitnik et al., 2014)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in proteolysis

inferred from sequence or structural similarity with HGNC:7154

(Gene Ontology Curators, 2002-)

inferred from sequence model

(Sitnik et al., 2014)

inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR008753, InterPro:IPR018497

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Sitnik et al., 2014)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000199753

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NEPRILYSINS

Protein Family (UniProt)

Belongs to the peptidase M13 family. (Q9W436)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NEPRILYSINS -: Neprilysins belong to the MEROPS M13 family of metalloproteases. The majority of proteins of this family are integral membrane proteins located at the cell surface, acting as ectoenzymes that catalyze the hydrolysis of extracellular signaling peptides. They contain all four of the conserved motifs defined as important for catalytic activity. (Adapted from FBrf0214506 and FBrf0239474.)

Protein Function (UniProtKB)

Metalloendoprotease which functions in fertility and memory formation (PubMed:24395329, PubMed:27629706). Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories (PubMed:27629706). Required in males to maximise egg-laying in female mates and is also required in females for their fertility (PubMed:24395329).

(UniProt, Q9W436)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nep1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W436)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nep1-RA

FBtr0070873

NM_078501

3368

849

Nep1-RB

FBtr0070872

NM_167059

3389

849

Nep1-RC

FBtr0340032

NM_001297996

3557

849

Nep1-RD

FBtr0343930

NM_001297997

4026

849

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nep1-PA

FBpp0070838

96.5

849

5.46

FBpp0070837

96.5

849

5.46

FBpp0309046

96.5

849

5.46

FBpp0310420

96.5

849

5.46

Q9W436

NP_001284926

AHN59397

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

849 aa isoforms: Nep1-PA, Nep1-PB, Nep1-PC, Nep1-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W436

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nep1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.10

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

adult midgut progenitor cell

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic/larval tracheal dorsal trunk

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

adult stage

adult mushroom body | restricted

(Kobayashi et al., 2006)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

Comment: levels decline with age

(Iijima-Ando et al., 2008)

Additional Descriptive Data

The level of Nep1 declines with age in adults. It was reduced by ~40% by 25 days as compared to the level at 2 days.

(Iijima-Ando et al., 2008)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nep1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nep1

View exonic expression by tissue for Dmel\Nep1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029843

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31547/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029843

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029843

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029843

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5905

Flygut - An atlas of the Drosophila adult midgut

FBgn0029843

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Nep1

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nep1

Transgenic constructs containing regulatory region of Nep1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6238

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Nep1^GD3251

lethal, with Scer\GAL4^Tub.PU

Nep1^GD11797

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Nep1^GD3251

lethal - all die during P-stage, with Scer\GAL4^αTub84B.PL

Nep1^UAS.cJa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Nep1^GD11797

viable, with Scer\GAL4^pnr-MD237

Nep1^GD11797

viable, with Scer\GAL4^tin.CΔ4

Nep1^GD11797

Sterility

Allele

female semi-sterile | conditional, with Scer\GAL4^hs.2sev

Nep1^GD11797

female semi-sterile | conditional, with Scer\GAL4^nSyb.PS

Nep1^GD11797

female semi-sterile | conditional, with Scer\GAL4^Send1.4kb

Nep1^GD11797

female semi-sterile | conditional, with Scer\GAL4^Tub.PU

Nep1^GD11797

male semi-sterile | conditional, with Scer\GAL4^hs.2sev

Nep1^GD11797

male semi-sterile | conditional, with Scer\GAL4^Tub.PU

Nep1^GD11797

Other Phenotypes

Allele

abnormal memory | adult stage, with Scer\GAL4^c739

Nep1^GD11797

abnormal memory | adult stage, with Scer\GAL4^VT064246

Nep1^GD11797

visible, with Scer\GAL4^69B

Nep1^UAS.cJa

visible, with Scer\GAL4^bs-1348

Nep1^UAS.cJa

visible, with Scer\GAL4^da.G32

Nep1^UAS.cJa

Phenotype manifest in

Allele

wing, with Scer\GAL4^69B

Nep1^UAS.cJa

wing, with Scer\GAL4^bs-1348

Nep1^UAS.cJa

wing, with Scer\GAL4^da.G32

Nep1^UAS.cJa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\MMEL1

12 of 14

Yes

Hsap\MME

11 of 14

Yes

7 of 14

7 of 14

7 of 14

6 of 14

5 of 14

Yes

Hsap\PHEX

5 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Mmel1

12 of 14

Yes

Rnor\Mme

10 of 14

Yes

8 of 14

7 of 14

6 of 14

5 of 14

Yes

Rnor\Phex

5 of 14

Yes

Mus musculus (laboratory mouse) (8)

Mmus\Mmel1

11 of 14

Yes

Mmus\Mme

11 of 14

Yes

7 of 14

7 of 14

7 of 14

5 of 14

5 of 14

Yes

Mmus\Phex

5 of 14

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\mme

8 of 13

Yes

Xtro\mmel1

7 of 13

Yes

Xtro\ece2

6 of 13

Xtro\ecel1

4 of 13

Yes

Xtro\ece1

2 of 13

Xtro\hnrnpr

1 of 13

Xtro\phex

1 of 13

Yes

Danio rerio (Zebrafish) (6)

Drer\mmel1

9 of 14

Yes

6 of 14

6 of 14

6 of 14

5 of 14

Yes

Drer\kel

4 of 14

Caenorhabditis elegans (Nematode, roundworm) (27)

Cele\nep-2

12 of 14

Yes

Cele\nep-1

8 of 14

Cele\nep-11

8 of 14

Yes

Cele\nep-12

6 of 14

Yes

Cele\nep-22

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Cele\nep-18

4 of 14

Cele\nep-20

4 of 14

Cele\nep-21

4 of 14

Yes

Cele\nep-23

4 of 14

Cele\nep-24

4 of 14

Cele\nep-26

4 of 14

Yes

Cele\nep-4

3 of 14

Cele\nep-9

3 of 14

Cele\nep-25

3 of 14

Yes

Cele\nep-16

2 of 14

Yes

Cele\nep-19

2 of 14

Yes

Cele\F41C6.4

1 of 14

Cele\nep-7

1 of 14

Cele\nep-14

1 of 14

Yes

Cele\nep-15

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP009791

12 of 12

Yes

5 of 12

4 of 12

4 of 12

3 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nep1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

Nep4

9 of 13

Nep3

8 of 13

Nep2

6 of 13

goe

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

neurodegenerative disease, MME-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

MME; membrane metalloendopeptidase

model of Charcot-Marie-Tooth disease axonal type 2T

IEA

(FlyBase, 2019-)

model of cerebellar ataxia type 43

IEA

(FlyBase, 2019-)

PHEX; phosphate regulating endopeptidase X-linked

model of X-linked dominant hypophosphatemic rickets

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MMEL1; membrane metalloendopeptidase like 1

12 of 14

618104

MME; membrane metalloendopeptidase

11 of 14

120520

ECE1; endothelin converting enzyme 1

7 of 14

600423

essential hypertension

ECE2; endothelin converting enzyme 2

7 of 14

610145

EEF1AKMT4-ECE2; EEF1AKMT4-ECE2 readthrough

7 of 14

ECEL1; endothelin converting enzyme like 1

6 of 14

605896

ARTHROGRYPOSIS, DISTAL, TYPE 5D; DA5D

distal arthrogryposis type 5D

KEL; Kell metallo-endopeptidase (Kell blood group)

5 of 14

613883

BLOOD GROUP--KELL SYSTEM; KEL

PHEX; phosphate regulating endopeptidase X-linked

5 of 14

300550

HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; XLHR

X-linked dominant hypophosphatemic rickets

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

MIST Molecular Interaction Search Tool

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Nep1

enhanceable

Appl

(Turrel et al., 2017)

Nep1

enhanceable

Bace

(Turrel et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Appl

suppressible

Nep1

(Turrel et al., 2017)

Appl|Bace

suppressible

Nep1

(Turrel et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58041

DroID - A comprehensive database of gene and protein interactions.

FBgn0029843

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-15

Cytogenetic map

5D4-5D5

Sequence location

X:6,091,205..6,103,971 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5D4-5D5

Limits computationally determined from genome sequence between P{EP}EP1457^EP1457&P{EP}CG5928^EP1083 and P{EP}EP1311&P{EP}EP1384

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-15

(FlyBase, 2016)

1-15.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

22465

y¹ w^67c23 P{EPgy2}Nep1^EY21255

79257

y¹ w^* TI{CRIMIC.TG4.1}Nep1^{CR00415-TG4.1}/FM7h

65960

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06235}attP2

64911

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05784}attP40

VDRC

v108660

P{KK101227}VIE-260B

v27537

w¹¹¹⁸; P{GD11797}v27537

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH03315

Other clones

DPiM_GH03315

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029843

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029843

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG5894 CG5905

(FlyBase, 1996-)

Source for merge of: CG5905 CG5914

(FlyBase, 1996-)

Additional comments

Source for merge of CG5894 CG5905 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Source for merge of CG5905 CG5914 was sequence comparison ( date:001104 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Nep1 CG5894

(Shirras, 2001.8.23, Thomas et al., 2001)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG5894

(Jacobsen et al., 2006, Coates et al., 2000)

CG5905

(Meyer et al., 2021, Meyer et al., 2018.7.18, Yamaguchi and Takashima, 2018, Sekiya et al., 2017, Fukuoh et al., 2014, Keleman et al., 2009.8.5, Perkins et al., 2009, Chang et al., 2008)

CG5914

DmeNEP1

(Bland et al., 2008)

NEP

(Turner et al., 2001)

NEP1

(Lang et al., 2013, Iijima-Ando et al., 2008)

dNEP1

(Sekiya et al., 2017, Isaac et al., 2003, Shirras, 2001.8.23, Thomas et al., 2001)

nep1

(Meyer et al., 2011)

Name Synonyms

Neprilysin 1

(Meyer et al., 2011, Rebeiz et al., 2011, Chang et al., 2008, Thomas et al., 2001)

neprilysin 1

(Yamaguchi and Takashima, 2018)

Secondary FlyBase IDs

FBgn0029841
FBgn0029842

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31547

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W436

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W436

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W436

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029843

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31547/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029843

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029843

FlyMine - An integrated database for Drosophila genomics

FBgn0029843

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5905

MARRVEL_MODEL - MARRVEL (model organism gene)

31547

Linkouts

BioGRID - A database of protein and genetic interactions.

58041

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029843

DroID - A comprehensive database of gene and protein interactions.

FBgn0029843

DRSC - Results frm RNAi screens

FBgn0029843

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029843

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029843

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5905

Flygut - An atlas of the Drosophila adult midgut

FBgn0029843

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029843

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (66)

The following external sites may use different assemblies or annotations than FlyBase.

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