proneural - basic amphipathic alpha-helix - novel effector or modulator of Notch signaling - inhibits Neuralized-mediated endocytosis and signaling activity of Delta
Please see the JBrowse view of Dmel\Brd for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Gene model reviewed during 5.46
0.6 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
81 (aa); 9 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Brd using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reference states 4-8 hr AEL
Brd transcripts are detected in third instar larval eye discs in the morphogenetic furrow in closely spaced stripes, one anterior to the stripe of dpp staining in the furrow and one within the furrow and posterior to it. They are detected in the pupal wing at 8h APF in large clusters of proximal campaniform sensilla.
Brd transcripts are detected weakly in preblastoderm embryos, are abundant in 4-8hr embryos and drop off dramatically in later embryonic stages on northern blots. Brd is expressed specifically in proneural clusters in the imaginal discs. In the wing imaginal disc, it is present at the positions of all developing adult external sensory organs. Further, it was found that Brd expression precedes sensory organ precursor specification.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Brd in JBrowse3-42
3-36.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
The Brd 3' UTR confers negative regulatory activity on heterologous reporter genes in vivo.
Mutations of Brd cause either sensory organ multiplication or loss. Cell markers reveal that multiplication results from the determination of supernumerary precursor cells and loss from the inappropriate differentiation of all precursor cells as neurons.
Causes production of supernumerary chaetae and sensilla at or near normal positions. Brd alleles affect all classes of adult sensory organs. The combination of sensilla multiplication and loss phenotypes is made more severe by loss-of-function mutations at N and neur and are decreased in the presence of three wild-type copies of these genes.
Possibly "Hi" was a "Brd" allele.
Source for identity of: Brd CG3096
