MDC1, mu-2
Please see the JBrowse view of Dmel\mu2 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
4.0 (northern blot)
None of the polypeptides share 100% sequence identity.
1261 (aa); 139 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mu2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
mu2 transcripts are detected at all stages on northern blots with the highest levels in adults and somewhat lower levels in embryos and pupae. In situ hybridization reveals strong expression during oogenesis. Transcripts are first detected in the germarium in one cell of the oocysts which may be the oocyte. At stages S5 to S6, transcripts become transiently more concentrated at the posterior end of the oocyte. After stage S8-S9, they accumulate at the anterior end of the oocyte where they form a ring-shaped pattern. mu2 transcripts are also observed in larval somatic cells especially in proliferating tissues. Expression is increased in proliferating zones in the brain and the morphogenetic furrow of the eye disc. In embryos, mu2 transcripts are ubiquitous at early stages. In later stages, they are expressed in the proliferating nervous system.
JBrowse - Visual display of RNA-Seq signals
View Dmel\mu2 in JBrowse3-1.0
3-3.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.
mu2 controls some aspect of the oocyte nucleus, possibly chromosome structure or association of the chromosomes with the matrix, that modulates both DNA repair and meiotic recombination.
mu2 gene product potentiates the recovery of terminal (one break) deletions. The putative gene product is associated with oocyte chromosomes and modulates indirectly the repair of broken chromosome ends. Unrepaired broken ends are then 'healed' after fertilization to give terminally deleted chromosomes. mu2 gene product controls a structural element during meiosis that modulates the activity of DNA repair.
mu2 gene product potentiates the recovery of terminal (one break) deletions. The putative gene product is associated with oocyte chromosomes and modulates indirectly the repair of broken chromosome ends. Unrepaired broken ends are then 'healed' after fertilization to give terminally deleted chromosomes.
mu2 potentiates the recovery of terminal (one break) deletions, a type of chromosomal aberration that is otherwise very rare.
Source for identity of: mu2 CG1960