securin
novel protein required for sister chromatid separation in mitosis - shares functional similarities to securin a protein that acts to premature activation of separins - securin inhibits separase endoprotease activity via an inhibitory pseudosubstrate region
Please see the JBrowse view of Dmel\pim for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
199 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pim using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
pim transcripts are detected in embryos, third instar larvae, and pupae. By in situ hybridization, pim transcripts are seen distributed throughout the embryo up to embyronic cycle 16. At later stages they become restricted to the developing nervous system and appear to be correlated with mitotic proliferation.
JBrowse - Visual display of RNA-Seq signals
View Dmel\pim in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
pim is required for separation of sister chromatids in mitosis.
Five (unnamed) recessive lethal alleles have been isolated during a cytogenetic analysis of chromosomal region 31.