38B.9
Please see the JBrowse view of Dmel\pr for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
1.3, 1.1 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
168 (aa); 19 (kD observed)
Homohexamer formed of two homotrimers in a head to head fashion.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\pr in JBrowse2-54
2-53.9
2-53.6 +/- 0.2
2-54.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Transcription unit identified during molecular analysis of the neb genomic region.
pr gene product is very complex and exists as higher multimeric forms.
The enzyme sepiapterin synthase A, is involved in early steps leading to the synthesis of the drosopterins.
When pr+ has been translocated into the Y chromosome <up>T(Y;2)prC5</up>, the T(Y;2)prC5, cn1/prC4,cn1 flies show a variegated eye color.
Mutants deficient in pteridines. When pr+ has been translocated into the Y chromosome <up>T(Y;2)prC5</up>, the T(Y;2)prC5, cn1/prC4, cn1 flies show a variegated eye color. The suppressors su(s)2 and su(pr)3 restore the pyrimidine level of pr1 and prbw to that of wild-type or nearly wild-type.
Mutants deficient in pteridines.
Eye color ruby at hatching, darkening to purplish ruby with age.
Larval Malpighian tubules wild-type in color.
pr eye color autonomous in larval optic discs transplanted into wild-type hosts.
The P{lacW}l(2)k09314bk09314b insertion maps between pr and neb, mapping between the predicted neb promoter and transcription start site.
