FB2024_04 , released June 25, 2024
Aberration: Dmel\Df(2L)TW161
Open Close
General Information
Symbol
Df(2L)TW161
Species
D. melanogaster
Name
Deficiency (2L) Ted Wright
FlyBase ID
FBab0001648
Feature type
chromosomal_deletion
Also Known As
Df(2L)161
Computed Breakpoints include

38A6;40A4-40B1

Features within 38A6--40B1
Genomic Maps
Sequence coordinates
2L:19,795,851..20,061,370 (Df(2L)TW161:bk1)
(Marygold and Cook, 2016.11.11)
2L:22,247,111..22,532,279 (Df(2L)TW161:bk2)
(Marygold and Cook, 2016.11.11)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Stathakis et al., 1995, Siegel, 1981)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Holmes et al., 1998, Molina et al., 1997, Prout et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Chadov et al., 1994, Brittnacher and Ganetzky, 1984, Wright et al., 1976)
Breakpoints

38A6-38B1;40A4-40B1

(Holmes et al., 1998, Prout et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Brittnacher and Ganetzky, 1984, Wright et al., 1976)

38A6;40

(Chadov et al., 1994)

38A6--B1;[]

(Molina et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

l(2)39DEn << bk1 << sine << blis << bk2 << lt

Genetic mapping information
Comments

The 2L:19795851..20061370 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the right end of fs(2)ltoPP43, which published results say is not deleted. The right extent corresponds to the right end of barr, which published results say is deleted.

(Marygold and Cook, 2016.11.11)

The 2L:22247111..22532279 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of RpL21, which is deleted. The right extent corresponds to the left end of RpL5, which is not deleted.

(Marygold and Cook, 2016.11.11)

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)
Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0028752) Right limit of break 1 from polytene analysis (FBrf0089934) Limits of break 2 from polytene analysis (FBrf0028752)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
barr
(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Bl
(Cicchetti and Loverre, 1988, Siegel, 1981, Wright et al., 1976)
bur
(Spradling et al., 1999, Neufeld et al., 1998, BDGP Project Members, 1994-1999)
cad
(Harbecke and Lengyel, 1995)
crc
(Hewes et al., 2000, Siegel, 1981, Ganetzky, 1977, Wright et al., 1976)
Cul2
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
del
(Schupbach and Wieschaus, 1991)
dia
(BDGP Project Members, 1994-1999)
Fs(2)Ket
(Butler et al., 2001)
gl(2L)260-24
(Luschnig et al., 2004)
Gr39a
(BDGP Project Members, 1994-1999)
HIS-C
(Rushlow et al., 1984, Siegel, 1981)
l(2)38Aa
(Butler et al., 2001)
l(2)38ABa
(Butler et al., 2001)
l(2)39Aa
(Siegel, 1981)
l(2)39Ad
(Siegel, 1981)
l(2)39ADa
(Siegel, 1981)
l(2)39ADb
(Siegel, 1981)
l(2)39ADc
(Siegel, 1981)
l(2)39ADd
(Siegel, 1981)
l(2)39ADe
(Siegel, 1981)
l(2)39Ah
(Siegel, 1981)
l(2)39DEa
(Siegel, 1981)
l(2)39DEb
(Siegel, 1981)
l(2)39DEc
(Siegel, 1981)
l(2)39DEd
(Siegel, 1981)
l(2)39DEe
(Siegel, 1981)
l(2)39DEf
(Siegel, 1981)
l(2)39DEg
(Siegel, 1981)
l(2)39DEh
(Siegel, 1981)
l(2)39DEi
(Siegel, 1981)
l(2)39DEj
(Siegel, 1981)
l(2)39DEk
(Siegel, 1981)
l(2)39DEl
(Siegel, 1981)
l(2)39DEm
(Siegel, 1981)
l(2)39Ea
(Beaton, 1998.3.3)
l(2)01528
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)03832a
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)05287
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)Co
(Cicchetti and Loverre, 1988)
l(2)k05001
(BDGP Project Members, 1994-1999)
l(2)k07215
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k07312b
(BDGP Project Members, 1994-1999)
l(2)k08046
(BDGP Project Members, 1994-1999)
l(2)k09017a
(Doerig, 1999.8.9)
l(2)k09314b
(BDGP Project Members, 1994-1999)
l(2)k10239
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k11226
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k14505
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k14603b
(BDGP Project Members, 1994-1999)
Low
(Bhadra et al., 1997)
M(2)39F
(Wright et al., 1976)
mAcon1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Mpp6
(Cayirlioglu et al., 2001, BDGP Project Members, 1994-1999)
neb
(Spradling et al., 1999, Molina et al., 1997, BDGP Project Members, 1994-1999)
pr
(Butler et al., 2001, Cicchetti and Loverre, 1988, Ganetzky, 1977, Wright et al., 1976)
sine
(Holmes et al., 1998)
spir
(Schupbach and Wieschaus, 1991)
Su(dpp)39CDE
(Murthy, 1999.3.3)
tsh
(Soanes and Bell, 1999, Spradling et al., 1999, Duffy et al., 1996, Kerridge, 1996.1.25, Bilder and Scott, 1995, BDGP Project Members, 1994-1999, Fasano et al., 1991)
vari
(Beitel and Krasnow, 2000)
vkg
(BDGP Project Members, 1994-1999)
vls
(Butler et al., 2001, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)
Partially deleted / disrupted
blis
(Prout et al., 1997)
l(2)39DEn
(Siegel, 1981)
l(2)39DEo
(Siegel, 1981)
Molecular Data
Completely deleted
mRpS18B
(Marygold et al., 2007)
RpL21
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
amd
(Wright et al., 1976)
amos
(Ganetzky, 1977, Wright et al., 1976)
ap
(Cicchetti and Loverre, 1988)
CadN
(Wright et al., 1976)
cn
(Cicchetti and Loverre, 1988)
CycE
(BDGP Project Members, 1994-1999)
Ddc
(Wright et al., 1976)
Df31
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
dpp
(BDGP Project Members, 1994-1999)
eIF4A
(BDGP Project Members, 1994-1999)
esc
(Wright et al., 1976)
fs(2)ltoPP43
(Butler et al., 2001)
hook
(Wright et al., 1976)
l(2)37Fc
(Butler et al., 2001)
l(2)37Fe
(Butler et al., 2001, Jones and McGinnis, 1993)
l(2)37Fg
(Jones and McGinnis, 1993)
l(2)05095a
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k02501
(BDGP Project Members, 1994-1999)
l(2)k05636
(BDGP Project Members, 1994-1999)
l(2)k06113
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k06712
(BDGP Project Members, 2000-, Kania et al., 1995, BDGP Project Members, 1994-1999)
l(2)k07219
(BDGP Project Members, 1994-1999)
l(2)k07525
(BDGP Project Members, 1994-1999)
l(2)k07526
(BDGP Project Members, 1994-1999)
l(2)k07713
(BDGP Project Members, 1994-1999)
l(2)k08306
(BDGP Project Members, 1994-1999)
l(2)k09005
(BDGP Project Members, 1994-1999)
l(2)k11241
(BDGP Project Members, 1994-1999)
l(2)k11537
(BDGP Project Members, 1994-1999)
l(2)k14810
(BDGP Project Members, 1994-1999)
l(2)k16703
(BDGP Project Members, 1994-1999)
lt
(Cicchetti and Loverre, 1988, Siegel, 1981, Ganetzky, 1977, Wright et al., 1976)
mle
(Cicchetti and Loverre, 1988)
neb
(Butler, 2001)
Nipped-B
(BDGP Project Members, 1994-1999)
pk
(Cicchetti and Loverre, 1988)
rdo
(Wright et al., 1976)
RpL5
(Marygold et al., 2005)
RpL38
(Cicchetti and Loverre, 1988)
RpS26
(Wright et al., 1976)
scw
(Butler et al., 2001, Jones and McGinnis, 1993)
spi
(Jones and McGinnis, 1993)
st
(Cicchetti and Loverre, 1988)
stw
(Cicchetti and Loverre, 1988)
vlc
(BDGP Project Members, 1994-1999)
ytr
(BDGP Project Members, 1994-1999)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Lethal in combination with Df(2L)Exel6049.

(Kahsai et al., 2016)

Viable in combination with Df(2L)lt31 or Df(2L)lt64.

(Marygold and Cook, 2016.11.11)

Semilethal in combination with Df(2L)TW50. Lethal in combination with Df(2L)Sd37.

(Butler et al., 2001)
NOT in combination with other aberrations

Associated with a Minute phenotype.

(Marygold and Cook, 2016.11.11)

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpphr4.

(Nicholls and Gelbart, 1998)

Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

(Duffy et al., 1996)

Deficient embryos show a mutant midgut phenotype: variable anterior and absent central constriction.

(Bilder and Scott, 1995)

Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.

(Pauli et al., 1995)

Poorly differentiated.

(Smith et al., 1993)

Trans-heterozygotes with tsh1 are semilethal: escapers have malformed prothoracic trochanters. No tsh gene product produced.

(Fasano et al., 1991)

Shows a Minute phenotype.

(Wright et al., 1976)

Moderate M phenotype

Stocks (3)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

Interchromosomal effect on crossing-over (IEC) is not observed in Df(2L)TW161 heterozygous females.

(Chadov et al., 1994)
Synonyms and Secondary IDs (7)
References (78)