Dm_2L:104545
memory suppressor gene - functions in a single dopamine neuron by supporting the process of active forgetting - controls dopamine activity for forgetting by modulating the presynaptic AZ structure - RNAi knockdown of sickie enhances memory through effects in dopaminergic neurons - regulates F-actin-mediated axonal growth in mushroom body neurons via the non-canonical Rac-Cofilin pathway - required for activation of Relish in the innate immune response
Please see the JBrowse view of Dmel\sick for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Gene model reviewed during 5.45
Gene model reviewed during 5.48
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sick using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as salivary gland primordium
Comment: reported as embryonic leading edge cell specific anlage
Comment: reported as dorsal/lateral sensory complexes
sick protein is broadly expressed in the neuropil of the pupal brain. Intense labeling can be observed in the core region of developing alpha/beta Kenyon cell axon bundles.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sick in JBrowse2-54
2-53.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: sick CG33316
Source for merge of: sick CG13964
Source for merge of: CG13959 CG13960 CG13961
Source for merge of: sick CG13958
Annotations CG42589 and CG13958 merged as CG43720 in release 5.43 of the genome annotation. Merge supported by GenBank accession GH291268 (MODENCODE_DM_A PCR-derived clone) and by second tier modENCODE junction (FBrf0217580).
Annotations CG34343 and CG13964 merged as CG42589 in release 5.18 of the genome annotation.
Annotations CG10662 and CG33316 merged as CG34343 in release 5.2 of the genome annotation.
Annotations CG13959, CG13960 and CG13961 merged as CG33316 in release 3.2 of the genome annotation.
Source for identity of: CG10662 sick