β-tubulin, tubulin, β tubulin, βtubulin, βTub98C
Please see the JBrowse view of Dmel\βTub97EF for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
1.8 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\βTub97EF using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reference states 0-21 hr AEL
When localization of acetylated or glutamylated tubulin was detected, it was found only in stabilized microtubules.
JBrowse - Visual display of RNA-Seq signals
View Dmel\βTub97EF in JBrowse3-94
3-92.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Daur\βTub97EF and βTub97EF were thought to have discordant introns, but this is now known to be an error in the published sequence, the introns are concordant.
βTub97EF encodes a B4 β-Tubulin function.
Tubulins are the main structural components of microtubules in mitotic and meiotic spindles, cilia, flagella, neural processes and the cytoskeleton; nontubulin proteins (MAPS or microtubule-associated proteins) are involved along with tubulins in the formation of specialized microtubules (Theurkauf, Baum, Bo and Wensink, 1986; Rudolph, Kimble, Hoyle, Subler and Raff, 1987). Tubulin proteins are found in a wide variety of species from unicellular organisms to man; their biochemical and molecular structure is highly conserved. The α- and β-subunits from different organisms can be combined in vitro into hybrid microtubule structures and there is a high level of primary amino acid sequence identity in the proteins (Sanchez, Natzle, Cleveland, Kirschner and McCarthy, 1980; Raff, 1984). In D.melanogaster, two multigene families, each made up of four members, code for α- and β-tubulins, each tubulin subunit being a 55,000 dalton polypeptide. The tubulin genes in each multigene family are dispersed in the second and/or third chromosomes rather than arranged in clusters. βTub97EF is a structural gene for β-tubulin. It is transcribed into mRNA that occurs ubiquitously throughout development. βTub97EF is expressed coordinately with βTub56D, but the βTub97EF transcripts are much less prevalent. They occur at highest concentration during the first half of embryogenesis and the first and second larval instars (Natzle and McCarthy, 1984). No protein variant has been described (Gasch et al., 1988).
Source for merge of: βTub97EF CG4869