FB2024_02 , released April 23, 2024
Gene: Dmel\Ance
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General Information
Symbol
Dmel\Ance
Species
D. melanogaster
Name
Angiotensin converting enzyme
Annotation Symbol
CG8827
Feature Type
protein_coding_gene
FlyBase ID
FBgn0012037
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Race, ACE, BG:DS08220.3

Key Links
Genomic Location
Cytogenetic map
34E2-34E2
Sequence location
Recombination map
2-50
RefSeq locus
NT_033779 REGION:13905645..13909212
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables metallopeptidase activity
inferred from direct assay
(Kim et al., 2003)
enables peptidyl-dipeptidase activity
inferred from direct assay
(Akif et al., 2012, Rylett et al., 2007, Bingham et al., 2006, Siviter et al., 2002, Wilson et al., 2002, Coates et al., 2000, Houard et al., 1998, Isaac et al., 1998, Williams et al., 1996, Cornell et al., 1995)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables metallopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000828236
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001548
(InterPro Project Members, 2004-)
enables peptidyl-dipeptidase activity
inferred from electronic annotation with InterPro:IPR001548
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in metamorphosis
inferred from expression pattern
(Siviter et al., 2002)
involved_in peptide hormone processing
inferred from direct assay
(Wilson et al., 2002, Houard et al., 1998, Isaac et al., 1998)
involved_in proteolysis
inferred from direct assay
(Akif et al., 2012, Rylett et al., 2007, Bingham et al., 2006, Siviter et al., 2002, Wilson et al., 2002, Houard et al., 1998, Isaac et al., 1998, Williams et al., 1996, Cornell et al., 1995)
involved_in response to symbiotic bacterium
inferred from expression pattern
(Xi et al., 2008)
involved_in sexual reproduction
inferred from expression pattern
(Rylett et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001548
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Rylett et al., 2007, Siviter et al., 2002, Houard et al., 1998, Cornell et al., 1995)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN002575170
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR001548
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000828236
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peptidase M2 family. (Q10714)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
ANGIOTENSIN-CONVERTING ENZYME-LIKE PEPTIDYL-DIPEPTIDASES -
Drosophila angiotensin-converting enzyme-like peptidyl-dipeptidases are secreted peptidases that remove the two terminal amino acids from peptides by hydrolysis. They share ancestry with the membrane-anchored mammalian angiotensin I-converting enzyme (ACE). Although the endogenous target(s) of these enzymes have not been identified, they have been shown to cleave various mammalian ACE peptide hormone targets and peptide hormones from other insects. They belong to MEROPS family M2. (Adapted from FBrf0129770, FBrf0100789 and FBrf0105845.)
Protein Function (UniProtKB)
May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.
(UniProt, Q10714)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(2)34Eb
Heteroallelic combinations escape about 10% with thin bristles; female fertile; male sterile.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ance for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q10714)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ance-RA
FBtr0080552
NM_057698
2004
615
Ance-RB
FBtr0080553
NM_165070
2062
615
Ance-RC
FBtr0343667
NM_001298986
2048
615
Additional Transcript Data and Comments
Reported size (kB)

2.1 (northern blot)

(Cornell et al., 1995)

4.0, 2.0 (northern blot)

(Tatei et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ance-PA
FBpp0080129
70.9
615
4.78
Q10714
NP_477046
AAF53353
Ance-PB
FBpp0080130
70.9
615
4.78
Q10714
NP_723852
AAN10856
Ance-PC
FBpp0310259
70.9
615
4.78
Q10714
NP_001285915
AHN54429
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

615 aa isoforms: Ance-PA, Ance-PB, Ance-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

615 (aa); 67 (kD observed)

(Cornell et al., 1995)

615 (aa)

(Tatei et al., 1995)
Comments
External Data
Post Translational Modification

Glycosylated.

(UniProt, Q10714)
Crossreferences
InterPro - A database of protein families, domains and functional sites
MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ance using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.49

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
amnioserosa anlage in statu nascendi
(Rusch and Levine, 1997)
organism | dorsal
(Sandler and Stathopoulos, 2016)
embryonic stage 6
amnioserosa anlage
(Wharton et al., 2004)
embryonic stage 7 -- 8
amnioserosa anlage
(Fisher et al., 2012)
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
amnioserosa primordium
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
dorsal head epidermis primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
embryonic stage 12
pericardial cell primordium
(Tatei et al., 1995)
dorsal vessel primordium
(Tatei et al., 1995)
embryonic stage 13 -- 16
amnioserosa
(Fisher et al., 2012)
dorsal head epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
prothoracic gland
(Fisher et al., 2012)
embryonic stage 15
lateral head epidermis | dorsal

Comment: dorsolateral stripe

(Chang et al., 2001)
adult stage | male
male accessory gland secondary cell
(Rylett et al., 2007)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Tatei et al., 1995)
embryonic stage 5 -- 13
amnioserosa
(Tatei et al., 1995)
embryonic stage 9 -- 15

Comment: reference states 4-12 hr AEL

(Tatei et al., 1995)
embryonic stage 10 -- 17
embryonic/larval anterior midgut
(Tatei et al., 1995)
embryonic/larval posterior midgut
(Tatei et al., 1995)
Additional Descriptive Data

The major 2kb Ance transcript is expressed throughout development but is not present in ovaries. Ance transcripts are detected in embryos by in situ hybridization in the amnioserosa from 1.5 hrs through germ band shortening. Expression is detected in the anterior and posterior midguts in germ band elongated and retracting embryos. In later embryos, expression appears in pericardial cells associated with the dorsal vessel. In zen and dpp mutants, there is a complete absence of staining in the amnioserosa but midgut expression is normal.

(Tatei et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
male accessory gland secondary cell
(Rylett et al., 2007)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Rylett et al., 2007, Siviter et al., 2002, Houard et al., 1998, Cornell et al., 1995)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ance in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ance
Transgenic constructs containing regulatory region of Ance
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal - all die before end of P-stage, with Scer\GAL4btl.PU
lethal - all die during P-stage, with Scer\GAL4Act5C.PI
partially lethal, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4Mhc.PK
partially lethal, with Scer\GAL4repo
partially lethal - majority die, with Scer\GAL4how-24B
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Act5C.PI
viable, with Scer\GAL4elav-C155
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4RapGAP1-OK6
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal body color | adult stage, with Scer\GAL4elav-C155
decreased rate of adult locomotory behavior, with Scer\GAL4Act5C.PI
decreased rate of adult locomotory behavior, with Scer\GAL4Mef2.PR
decreased rate of flight behavior, with Scer\GAL4Mef2.PR
decreased rate of larval locomotory behavior, with Scer\GAL4Mef2.PR
decreased size | adult stage, with Scer\GAL4elav-C155
short lived, with Scer\GAL4Mef2.PR
visible | adult stage, with Scer\GAL4elav-C155
wild-type
Phenotype manifest in
Allele
adult cuticle, with Scer\GAL4elav-C155
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
embryonic/larval hypodermal muscle | larval stage, with Scer\GAL4Mef2.PR
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
scutellar bristle, with Scer\GAL4elav-C155
wing, with Scer\GAL4elav-C155
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\ACE
9 of 14
Yes
Yes
3  
Hsap\ACE2
8 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Ace3
10 of 14
Yes
Yes
Rnor\Ace
10 of 14
Yes
Yes
Rnor\Ace2
6 of 14
No
Yes
Mus musculus (laboratory mouse) (3)
Mmus\Ace3
11 of 14
Yes
Yes
Mmus\Ace
8 of 14
No
Yes
Mmus\Ace2
7 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\ace
5 of 13
Yes
Yes
Xtro\ace2
3 of 13
No
Yes
Xtro\dsp
1 of 13
No
No
Danio rerio (Zebrafish) (2)
Drer\ace
10 of 14
Yes
Yes
Drer\ace2
8 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\acn-1
9 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (10)
Agam\ANCE2
12 of 12
Yes
Yes
Agam\ANCE4
12 of 12
Yes
Yes
Agam\ANCE5
12 of 12
Yes
Yes
Agam\ANCE6
12 of 12
Yes
Yes
Agam\ANCE9
6 of 12
No
Yes
Agam\ANCE3
5 of 12
No
Yes
Agam\ANCE1
4 of 12
No
Yes
Agam\ANCE7
4 of 12
No
No
Agam\ANCE8
4 of 12
No
No
Agam\AgaP_AGAP009753
3 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ance. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Acer
11 of 13
Ance-3
9 of 13
Ance-4
7 of 13
Ance-5
7 of 13
Ance-2
6 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACE; angiotensin I converting enzyme
9 of 14
106180
     
    ACE2; angiotensin converting enzyme 2
    8 of 14
    300335
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        MIST Molecular Interaction Search Tool
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-50
        Cytogenetic map
        34E2-34E2
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        34E2-34E2
        Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        34E-34E
        (determined by in situ hybridisation)
        (Tatei et al., 1995)
        34A-34A
        (determined by in situ hybridisation)
        (Cornell et al., 1995)
        Experimentally Determined Recombination Data
        Location

        2-50

        (FlyBase, 2016)

        2-45.3

        (Comeron et al., 2012)

        2-

        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (12)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (336)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Rylett et al., 2007)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              zen directly activates the amnioserosa-specific expression of a downstream target gene, Ance.

              (Rusch and Levine, 1997)

              Isolated from a 4-8 hour embryo cDNA library, using a fragment of a human ACE cDNA as a probe.

              (Cornell et al., 1995)

              An Ance cDNA has been cloned.

              (Cornell et al., 1995)

              A putative dpp/zen target gene, Ance, a homologue of the angiotensin converting enzyme, is expressed in the presumptive amnioserosa. The dpp signal leads to activation of Ance and to the determination of different dorsal cell fates.

              (Rusch et al., 1995)

              Ance has been cloned and sequenced, and its expression pattern has been analysed.

              (Tatei et al., 1995)

              The Coates and Levine groups published conflicting map locations and their submitted sequences conflicted in several places, but subsequent work has confirmed that their genes are the same. Clarification is in FBrf0089312.

              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Ance anon- EST:fe3D10

              (Bayraktaroglu, 2000.11.2)
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: Ance CG8827

              (Guan, 1999.11)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (17)
              Reported As
              Symbol Synonym
              ACE
              (Shirras et al., 2005, Smith et al., 2005, Isaac et al., 2002, Isaac et al., 1998, Schoofs et al., 1998)
              ANCE
              (Xi et al., 2008, Bingham et al., 2006)
              AnCE
              (Masuyer et al., 2014, Akif et al., 2011, Akif et al., 2010, Akif et al., 2010, Kim et al., 2003, Zhu et al., 2001, Williams et al., 1996, Cornell et al., 1995)
              Ance
              (Ghalayini and Boulianne, 2023, Herrera and Cauchi, 2023, Xu et al., 2023, Ciesielski et al., 2022, Egan et al., 2022, Kim, 2022.8.19, Marcogliese et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Cattenoz et al., 2021, Herrera and Cauchi, 2021, Ing-Simmons et al., 2021, Cho et al., 2020, Jevitt et al., 2020, Gabrawy et al., 2019, Sharma et al., 2019, Solares et al., 2018, Kim et al., 2017, Dominguez et al., 2016, Gene Disruption Project members, 2016-, Saha et al., 2016, Gene Disruption Project members, 2015-, Sawala et al., 2015, Van Bortle et al., 2015, Butchar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Nien et al., 2011, Zheng et al., 2011, Flaherty et al., 2009, Tarone et al., 2008, Wang et al., 2008, Xi et al., 2008, Rylett et al., 2007, Dionne et al., 2006, Siviter et al., 2002, Wilson et al., 2002, Isaac et al., 2000)
              BG:DS08220.3
              (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
              CG8827
              (National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Çiçek et al., 2016, Ni et al., 2011.7.19, Zheng et al., 2011, Ni et al., 2010.12.1, Moorman et al., 2006, Gonzalez-Aguero et al., 2005, Swanson et al., 2004)
              RACE
              (Stein et al., 2002)
              Race
              (Frampton et al., 2022, Ashe, 2016, Sandler and Stathopoulos, 2016, Sandler and Stathopoulos, 2016, Sawala et al., 2015, Saunders et al., 2013, Liang et al., 2012, Sawala et al., 2012, Lynch and Roth, 2011, Haecker et al., 2008, Miles et al., 2008, Wang et al., 2008, Bonds et al., 2007, Liang et al., 2007, Ashe, 2006, Lin et al., 2006, Mizutani et al., 2005, Okumura et al., 2005, Xu et al., 2005, Xu et al., 2005, Wharton et al., 2004, Xu et al., 2004, Xu et al., 2003, Kumar et al., 2002, Xu et al., 2002, Decotto and Ferguson, 2001, Gurdon and Bourillot, 2001, Ross et al., 2001, Ashe et al., 2000, Ashe and Levine, 1999, Podos and Ferguson, 1999, Rusch and Levine, 1997, Frank and Rushlow, 1996, Rusch et al., 1995, Tatei, 1995.8.21, Tatei et al., 1995)
              ance
              (Somogyi et al., 2010, Miotto et al., 2006)
              anon-EST:fe3D10
              race
              (Xue et al., 2023, Winstanley et al., 2015, Levine and Davidson, 2005, Shimmi et al., 2005, Stathopoulos and Levine, 2005, Gurunathan et al., 2004, Yu et al., 2004, Chang et al., 2003, Kunwar et al., 2003, Reim et al., 2003, Eldar et al., 2002, Stathopoulos et al., 2002, Chang et al., 2001, Yu et al., 2000, Riesgo-Escovar and Hafen, 1997, Biehs et al., 1996)
              Name Synonyms
              Ance
              (Duarte et al., 2022)
              Angiotensin Converting Enzyme
              (Xi et al., 2008)
              Angiotensin I-converting enzyme
              (Rylett et al., 2007)
              Angiotensin converting enzyme
              (Lee et al., 2014, Flaherty et al., 2009, Hurlbut et al., 2009)
              Race
              (Newton et al., 2015)
              Related to angiotensin converting enzyme
              angiotensin-converting enzyme
              (Bingham et al., 2006)
              anon-fast-evolving-3D10
              Secondary FlyBase IDs
              • FBgn0014013
              • FBgn0025190
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 76 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.
              PDB - An information portal to biological macromolecular structures
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (197)