kas, kastchen, l(3)neo13, l(3)j8E8
transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion - controls glial cell migration
Please see the JBrowse view of Dmel\foi for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Glycosylated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\foi using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\foi in JBrowse3-26
3-20.1
3-25.2
3-26 +/- 1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
foi is required during embryonic development for both germ cell ensheathment and gonad compaction.
Four EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
Isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis.
Mutants exhibit specific germ cell migration defects.
Source for merge of: foi CG6817
Source for merge of: foi l(3)neo13 l(3)j8E8
Source for merge of: foi kas
The gene is named "fear of intimacy" after the mutant phenotype; the germ cells fail to become intimately associated with one another in the gonad in mutant embryos.
"kastchen" means "small box" in German.