FlyBase Gene Report: Dmel\ZnT63C

antennal anlage in statu nascendi

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

(Fisher et al., 2012)

procrystal cell

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval plasmatocyte

(Fisher et al., 2012)

(Fisher et al., 2012)

sensory nervous system primordium

(Fisher et al., 2012)

third instar larval stage

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval Malpighian tubule

(Wang et al., 2009)

embryonic/larval midgut | restricted

(Wang et al., 2009)

embryonic/larval midgut enterocyte

(Wang et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Lye et al., 2013, Lye et al., 2012)

located_in basolateral plasma membrane

inferred from direct assay

(Lye et al., 2013, Lye et al., 2012)

located_in plasma membrane

inferred from direct assay

(Wang et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ZnT63C in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ZnT63C

View exonic expression by tissue for Dmel\ZnT63C

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035432

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38407/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035432

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035432

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035432

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17723

Flygut - An atlas of the Drosophila adult midgut

FBgn0035432

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\ZnT63C

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ZnT63C

Transgenic constructs containing regulatory region of ZnT63C

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6093

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

ZnT63C²

lethal - all die before end of first instar larval stage

ZnT63C¹

lethal - all die before end of larval stage, with Scer\GAL4^Act5C.PI

ZnT63C^RNAi.UAS.cWa

lethal - all die before end of larval stage, with Scer\GAL4^da.G32

lethal - all die before end of larval stage, with Scer\GAL4^NP3084

ZnT63C^RNAi.UAS.cWa

lethal - all die before end of larval stage, with Scer\GAL4^NP5021

ZnT63C^RNAi.UAS.cWa

viable

ZnT63C^c01408

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ZnT63C^GD2276

viable, with Scer\GAL4^da.G32

ZnT63C^RNAi.UAS.cWa

viable, with Scer\GAL4^Mef2.PR

ZnT63C^GD2276

viable, with Scer\GAL4^pnr-MD237

ZnT63C^GD2276

viable, with Scer\GAL4^tin.CΔ4

ZnT63C^GD2276

viable, with Scer\GAL4^Tub.PU

Sterility

Allele

fertile

ZnT63C^c01408

fertile, with Scer\GAL4^da.G32

ZnT63C^RNAi.UAS.cWa

Other Phenotypes

Allele

chemical sensitive, with Scer\GAL4^NP1093

ZnT63C^KK102261

majority die during larval stage

ZnT63C²

melanotic mass phenotype, with Scer\GAL4^Tub.PU

ZnT63C^UAS.Tag:FLAG

some die during larval stage, with Scer\GAL4^Act5C.PI

ZnT63C^RNAi.UAS.cWa

some die during larval stage, with Scer\GAL4^da.G32

ZnT63C^UAS.cWa

some die during larval stage, with Scer\GAL4^NP3084

ZnT63C^RNAi.UAS.cWa

some die during larval stage, with Scer\GAL4^NP5021

ZnT63C^RNAi.UAS.cWa

some die during P-stage

ZnT63C²

some die during third instar larval stage, with Scer\GAL4^da.G32

ZnT63C^RNAi.UAS.cWa

Phenotype manifest in

Allele

melanotic mass, with Scer\GAL4^Tub.PU

ZnT63C^UAS.Tag:FLAG

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\SLC30A1

12 of 14

Yes

Hsap\SLC30A10

10 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Slc30a1

12 of 14

Yes

Rnor\Slc30a10

10 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Rnor\Slc30a2

1 of 14

Mus musculus (laboratory mouse) (9)

Mmus\Slc30a1

11 of 14

Yes

Mmus\Slc30a10

10 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Xenopus tropicalis (Western clawed frog) (12)

Xtro\slc30a1

10 of 13

Yes

Xtro\slc30a10

4 of 13

Yes

Xtro\LOC101730999

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slc45a3

1 of 13

Yes

Danio rerio (Zebrafish) (10)

Drer\slc30a1a

12 of 14

Yes

Drer\slc30a1b

11 of 14

Yes

Drer\slc30a10

6 of 14

Yes

Drer\LOC100002134

4 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\cdf-1

9 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\toc-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP005918

12 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT2G04620

2 of 13

Yes

Atha\AT3G12100

2 of 13

Yes

Atha\MTPA1

2 of 13

Yes

Atha\MTPA2

2 of 13

Yes

Atha\MTPB1

2 of 13

Yes

Atha\ZAT

2 of 13

Yes

Atha\AT1G33020

1 of 13

Yes

Atha\AT2G47830

1 of 13

Atha\AT5G38380

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\ZRC1

13 of 13

Yes

Scer\COT1

12 of 13

Yes

Scer\MSC2

2 of 13

Scer\MMT1

1 of 13

Scer\MMT2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\zhf1

12 of 12

Yes

Spom\cis4

2 of 12

Escherichia coli (enterobacterium) (1)

Ecol\zitB

4 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ZnT63C. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

6 of 13

3 of 13

3 of 13

3 of 13

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC30A10; solute carrier family 30 member 10

model of hypermanganesemia with dystonia 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ZnT63C^KK102261

ameliorates Friedreich ataxia 1

modeled by fh^RNAi.UAS.cAa

(Soriano et al., 2016)

DOES NOT ameliorate xanthinuria

modeled by ry^HMS02827

(Yin et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC30A1; solute carrier family 30 member 1

12 of 14

609521

SLC30A10; solute carrier family 30 member 10

10 of 14

611146

HYPERMANGANESEMIA WITH DYSTONIA 1; HMNDYT1

hypermanganesemia with dystonia 1

SLC30A8; solute carrier family 30 member 8

4 of 14

611145

TYPE 2 DIABETES MELLITUS; T2D

type 2 diabetes mellitus

SLC30A3; solute carrier family 30 member 3

3 of 14

602878

SLC30A4; solute carrier family 30 member 4

3 of 14

602095

SLC30A7; solute carrier family 30 member 7

3 of 14

611149

ZIEGLER-HUANG SYNDROME; ZHS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Hsap\SLC30A1

(Wang et al., 2020, Wang et al., 2009)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

ZnT63C - Agpat3

(Guruharsha et al., 2011)

ZnT63C - Atpα

(Guruharsha et al., 2011)

ZnT63C - CARPB

(Guruharsha et al., 2011)

ZnT63C - CG14767

(Guruharsha et al., 2011)

ZnT63C - CG15098

(Guruharsha et al., 2011)

ZnT63C - CG2065

(Guruharsha et al., 2011)

ZnT63C - CG2070

(Guruharsha et al., 2011)

ZnT63C - CG3164

(Guruharsha et al., 2011)

ZnT63C - CG31729

(Guruharsha et al., 2011)

ZnT63C - CG33253

(Guruharsha et al., 2011)

ZnT63C - CG7668

(Guruharsha et al., 2011)

ZnT63C - Karyβ3

(Guruharsha et al., 2011)

ZnT63C - KdelR

(Guruharsha et al., 2011)

ZnT63C - Kdsr

(Guruharsha et al., 2011)

ZnT63C - MRP

(Guruharsha et al., 2011)

ZnT63C - Mcad

(Guruharsha et al., 2011)

ZnT63C - Mec2

(Guruharsha et al., 2011)

ZnT63C - Ost48

(Guruharsha et al., 2011)

ZnT63C - OstΔ

(Guruharsha et al., 2011)

ZnT63C - PMCA

(Guruharsha et al., 2011)

ZnT63C - Rab5

(Guruharsha et al., 2011)

ZnT63C - Rdh1

(Guruharsha et al., 2011)

ZnT63C - SERCA

(Guruharsha et al., 2011)

ZnT63C - Scamp

(Guruharsha et al., 2011)

ZnT63C - Sec61α

(Guruharsha et al., 2011)

ZnT63C - Spindly

(Guruharsha et al., 2011)

ZnT63C - Spt-I

(Guruharsha et al., 2011)

ZnT63C - Surf4

(Guruharsha et al., 2011)

ZnT63C - Tecr

(Guruharsha et al., 2011)

ZnT63C - cPges

(Guruharsha et al., 2011)

ZnT63C - fax

(Guruharsha et al., 2011)

ZnT63C - jagn

(Guruharsha et al., 2011)

ZnT63C - porin

(Guruharsha et al., 2011)

ZnT63C - red

(Guruharsha et al., 2011)

ZnT63C - sax

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

suppressible

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

enhanceable

(Lye et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Chi et al., 2015)

Zip71B

suppressible

(Dechen et al., 2015)

Zip71B

enhanceable

(Dechen et al., 2015)

Zip89B

enhanceable

(Richards et al., 2015)

ZnT86D

suppressible

(Dechen et al., 2015)

ZnT86D

enhanceable