FB2024_03 , released June 25, 2024
Gene: Dmel\sona
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General Information
Symbol
Dmel\sona
Species
D. melanogaster
Name
sol narae
Annotation Symbol
CG9850
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034903
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
sol narae (sona) encodes a member of the ADAMTS family of proteases secreted to the extracellular matrix. It is involved in Wg signaling by promoting the secretion of the product of wg, and is essential for development and growth. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dimp

Key Links
Genomic Location
Cytogenetic map
59F7-60A1
Sequence location
Recombination map
2-104
RefSeq locus
NT_033778 REGION:23753477..23798395
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables metalloendopeptidase activity
inferred from direct assay
(Won et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables metalloendopeptidase activity
inferred from electronic annotation with InterPro:IPR001590
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN008529451
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in imaginal disc-derived appendage development
inferred from mutant phenotype
(Kim et al., 2016)
involved_in positive regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Won et al., 2019)
involved_in positive regulation of Wnt protein secretion
inferred from mutant phenotype
(Kim et al., 2016)
involved_in proteolysis
inferred from direct assay
(Won et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001590
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN008529451
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Kim et al., 2016)
located_in extracellular exosome
inferred from direct assay
(Won et al., 2019)
located_in extracellular space
inferred from direct assay
(Won et al., 2019, Kim et al., 2016)
located_in Golgi-associated vesicle
inferred from direct assay
(Kim et al., 2016)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
sol narae (sona) encodes a member of the ADAMTS family of proteases secreted to the extracellular matrix. It is involved in Wg signaling by promoting the secretion of the product of wg, and is essential for development and growth. [Date last reviewed: 2018-10-18]
Gene Group (FlyBase)
ADAM WITH THROMBOSPONDIN MOTIF -
A Disintegrin And Metalloprotease Thrombospondin motif (ADAMTS) belongs to the metzincin superfamily of metalloproteases. ADAMTS is related to ADAM proteins, sharing in part their domain organisation. However, ADAMTS includes proteins that contain a variable number of thrombospondin-like repeats instead of disintegrin and cysteine rich domains. ADAMTS proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506).
Pathway (FlyBase)
Positive Regulators of Wnt-TCF Signaling Pathway -
Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
Summary (Interactive Fly)

a member of A Disintegrin And Metalloprotease with ThromboSpondin motif (ADAMTS) family - positively regulates Wingless signaling by promoting Wg secretion - activates a subset of Wg signaling whose major function is the regulation of cell proliferation - a mutually positive genetic interaction exists between ana3 and sona - wing discs

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\sona for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry B7YZP6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Alternative translation stop created by use of multiphasic reading frames within coding region.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.42

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sona-RA
FBtr0100329
NM_137983
3588
639
sona-RC
FBtr0290120
NM_001144274
5497
1102
sona-RD
FBtr0310328
NM_001274228
4388
913
sona-RE
FBtr0310329
NM_001032400
4642
896
sona-RF
FBtr0310330
NM_001274229
3585
638
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
sona-PA
FBpp0072001
71.2
639
7.10
Q9W1J9
NP_611827
AAF47059
sona-PC
FBpp0288559
121.6
1102
7.28
B7YZP6
NP_001137746
ACL83199
sona-PD
FBpp0302011
101.6
913
6.67
A0A0B4KFG8
NP_001261157
AGB93687
sona-PE
FBpp0302012
99.0
896
8.54
Q2MGN5
NP_001027572
AAZ93569
sona-PF
FBpp0302013
71.2
638
7.45
A0A0B4KGD6
NP_001261158
AGB93688
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sona using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.23

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc | ubiquitous
(Kim et al., 2016)
leg disc | ubiquitous
(Kim et al., 2016)
eye-antennal disc | ubiquitous
(Kim et al., 2016)
Additional Descriptive Data

In contrast to the sona-GAL4 line, sona protein is distributed ubiquitously in wing, leg, and eye-antennal discs in late third instar larvae.

(Kim et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Kim et al., 2016)
located_in extracellular exosome
inferred from direct assay
(Won et al., 2019)
located_in extracellular space
inferred from direct assay
(Won et al., 2019, Kim et al., 2016)
located_in Golgi-associated vesicle
inferred from direct assay
(Kim et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sona in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sona
Transgenic constructs containing regulatory region of sona
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage, with Scer\GAL4Act.PU
lethal - all die before end of larval stage, with Scer\GAL4hh.PU
lethal - all die before end of larval stage, with Scer\GAL4ptc.PU
lethal - all die before end of P-stage
lethal - all die before end of P-stage, with Scer\GAL430A
lethal - all die before end of P-stage, with Scer\GAL4Act.PU
lethal - all die before end of P-stage, with Scer\GAL4GMR.PU
lethal - all die before end of P-stage, with Scer\GAL4nub.PU
lethal - all die during embryonic stage, with Scer\GAL4en.PU
lethal - all die during embryonic stage, with Scer\GAL4ptc.PU
partially lethal - majority die, with Scer\GAL430A
partially lethal - majority live, with Scer\GAL430A
partially lethal - majority live, with Scer\GAL4nub.PU
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal size | adult stage, with Scer\GAL4nub.PU
decreased body size | adult stage, with Scer\GAL4NP5284
majority die during larval stage, with Scer\GAL4ptc.PU
majority die during P-stage, with Scer\GAL430A
majority die during P-stage, with Scer\GAL4en.PU
majority die during P-stage, with Scer\GAL4hh.PU
majority die during P-stage, with Scer\GAL4NP5284
majority die during P-stage, with Scer\GAL4ptc.PU
short lived, with Scer\GAL430A
some die during larval stage, with Scer\GAL4NP5284
some die during larval stage, with Scer\GAL4nub.PU
some die during P-stage, with Scer\GAL4NP5284
some die during P-stage, with Scer\GAL4nub.PU
some die during P-stage, with Scer\GAL4ptc.PU
visible
visible, with Scer\GAL4nub.PU
visible (with sona13)
visible (with sona18)
visible (with sona47)
visible | adult stage, with Scer\GAL4nub.PU
visible | adult stage, with Scer\GAL4wg-Gal4
Phenotype manifest in
Allele
arista
embryonic/larval tracheal section | larval stage, with Scer\GAL4NP5284
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4wg.PU
femur
interommatidial bristle
interommatidial bristle, with Scer\GAL4GMR.PU
interommatidial bristle, with Scer\GAL4NP5284
interommatidial bristle (with sona13)
interommatidial bristle (with sona18)
interommatidial bristle (with sona47)
leg, with Scer\GAL4NP5284
leg, with Scer\GAL4wg.PU
ocellar bristle, with Scer\GAL4wg.PU
salivary gland | adult stage, with Scer\GAL4NP5284
unguis
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4wg.PU
wing | adult stage, with Scer\GAL4nub.PU
wing | adult stage, with Scer\GAL4wg-Gal4
wing blade
wing blade, with Scer\GAL4en.PU
wing blade, with Scer\GAL4nub.PU
wing blade, with Scer\GAL4wg.PU
wing margin bristle
wing vein, with Scer\GAL4ptc.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (39)
Hsap\ADAMTS1
2 of 14
Yes
No
1  
Hsap\ADAMTS2
2 of 14
Yes
No
Hsap\ADAMTS3
2 of 14
Yes
No
Hsap\ADAMTS4
2 of 14
Yes
No
Hsap\ADAMTS5
2 of 14
Yes
No
Hsap\ADAMTS6
2 of 14
Yes
No
Hsap\ADAMTS7
2 of 14
Yes
No
Hsap\ADAMTS8
2 of 14
Yes
No
Hsap\ADAMTS9
2 of 14
Yes
No
Hsap\ADAMTS12
2 of 14
Yes
No
Hsap\ADAMTS13
2 of 14
Yes
No
Hsap\ADAMTS14
2 of 14
Yes
No
Hsap\ADAMTS15
2 of 14
Yes
No
1  
Hsap\ADAMTS16
2 of 14
Yes
No
Hsap\ADAMTS17
2 of 14
Yes
No
Hsap\ADAMTS18
2 of 14
Yes
No
Hsap\ADAMTS19
2 of 14
Yes
No
Hsap\ADAMTS20
2 of 14
Yes
No
Hsap\ADAMTSL1
2 of 14
Yes
No
Hsap\ADAMTSL3
2 of 14
Yes
No
Hsap\PAPLN
2 of 14
Yes
No
Hsap\ADAM7
1 of 14
No
No
Hsap\ADAM9
1 of 14
No
No
Hsap\ADAM12
1 of 14
No
No
Hsap\ADAM19
1 of 14
No
No
Hsap\ADAM20
1 of 14
No
No
Hsap\ADAM21
1 of 14
No
No
1  
Hsap\ADAM22
1 of 14
No
No
Hsap\ADAM23
1 of 14
No
No
Hsap\ADAM33
1 of 14
No
No
Hsap\ADAMTS10
1 of 14
No
No
Hsap\ADAMTSL2
1 of 14
No
No
Hsap\ADAMTSL4
1 of 14
No
No
Hsap\ADAMTSL5
1 of 14
No
No
Hsap\ADGRB1
1 of 14
No
No
Hsap\THSD4
1 of 14
No
No
Hsap\THSD7A
1 of 14
No
No
Hsap\WFIKKN1
1 of 14
No
No
Hsap\WFIKKN2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (25)
Rnor\Adamts1
2 of 14
Yes
No
Rnor\Adamts4
2 of 14
Yes
No
Rnor\Adamts7
2 of 14
Yes
No
Rnor\Adamts8
2 of 14
Yes
No
Rnor\Adamts12
2 of 14
Yes
No
Rnor\Adamts15
2 of 14
Yes
No
Rnor\Adamts17
2 of 14
Yes
No
Rnor\Adamts18
2 of 14
Yes
No
Rnor\Adamts19
2 of 14
Yes
No
Rnor\Adamts5
1 of 14
No
No
Rnor\Adamts6
1 of 14
No
No
Rnor\Adamts9
1 of 14
No
No
Rnor\Adamts10
1 of 14
No
No
Rnor\Adamts13
1 of 14
No
No
Rnor\Adamts16
1 of 14
No
No
Rnor\Adamts20
1 of 14
No
No
Rnor\Adamtsl2
1 of 14
No
No
Rnor\Adamtsl3
1 of 14
No
No
Rnor\Adamtsl4
1 of 14
No
No
Rnor\Adamtsl5
1 of 14
No
No
Rnor\Sspo
1 of 14
No
No
Rnor\Thsd7a
1 of 14
No
No
Rnor\Thsd7b
1 of 14
No
No
Rnor\Wfikkn1
1 of 14
No
No
Rnor\Wfikkn2
1 of 14
No
No
Mus musculus (laboratory mouse) (30)
Mmus\Adamts1
2 of 14
Yes
No
Mmus\Adamts5
2 of 14
Yes
No
Mmus\Adamts6
2 of 14
Yes
No
Mmus\Adamts7
2 of 14
Yes
No
Mmus\Adamts8
2 of 14
Yes
No
Mmus\Adamts9
2 of 14
Yes
No
Mmus\Adamts10
2 of 14
Yes
No
Mmus\Adamts12
2 of 14
Yes
No
Mmus\Adamts13
2 of 14
Yes
No
Mmus\Adamts14
2 of 14
Yes
No
Mmus\Adamts15
2 of 14
Yes
No
Mmus\Adamts16
2 of 14
Yes
No
Mmus\Adamts17
2 of 14
Yes
No
Mmus\Adamts18
2 of 14
Yes
No
Mmus\Adamts20
2 of 14
Yes
No
Mmus\Adamts2
1 of 14
No
No
Mmus\Adamts3
1 of 14
No
No
Mmus\Adamts4
1 of 14
No
No
Mmus\Adamts19
1 of 14
No
No
Mmus\Adamtsl1
1 of 14
No
No
Mmus\Adamtsl2
1 of 14
No
No
Mmus\Adamtsl3
1 of 14
No
No
Mmus\Adamtsl4
1 of 14
No
No
Mmus\Adamtsl5
1 of 14
No
No
Mmus\Adgrb1
1 of 14
No
No
Mmus\Papln
1 of 14
No
No
Mmus\Sspo
1 of 14
No
No
Mmus\Thsd4
1 of 14
No
No
Mmus\Thsd7b
1 of 14
No
Yes
Mmus\Wfikkn2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (27)
Xtro\abo.2
1 of 13
Yes
Yes
Xtro\adam9
1 of 13
Yes
No
Xtro\adam12
1 of 13
Yes
No
Xtro\adam28.1
1 of 13
Yes
No
Xtro\adam28.2
1 of 13
Yes
No
Xtro\adamts3
1 of 13
Yes
No
Xtro\adamts6
1 of 13
Yes
No
Xtro\adamts13
1 of 13
Yes
No
Xtro\adamts15
1 of 13
Yes
No
Xtro\adamts16
1 of 13
Yes
No
Xtro\adamts17
1 of 13
Yes
No
Xtro\adamts19
1 of 13
Yes
No
Xtro\adamtsl1
1 of 13
Yes
No
Xtro\adamtsl3
1 of 13
Yes
No
Xtro\camkmt
1 of 13
Yes
No
Xtro\dock9
1 of 13
Yes
No
Xtro\fgfr2
1 of 13
Yes
No
Xtro\krt61
1 of 13
Yes
Yes
Xtro\LOC100498221
1 of 13
Yes
No
Xtro\med6
1 of 13
Yes
No
Xtro\rcn3
1 of 13
Yes
No
Xtro\sar1a
1 of 13
Yes
No
Xtro\tex10
1 of 13
Yes
No
Xtro\thsd4
1 of 13
Yes
No
Xtro\tmem170b
1 of 13
Yes
Yes
Xtro\traf7
1 of 13
Yes
Yes
Xtro\ubxn2a
1 of 13
Yes
No
Danio rerio (Zebrafish) (30)
Drer\adamts3
2 of 14
Yes
No
Drer\adamts10
2 of 14
Yes
No
Drer\adamts12
2 of 14
Yes
No
Drer\adamts15a
2 of 14
Yes
No
Drer\adamts17
2 of 14
Yes
No
Drer\adamts18
2 of 14
Yes
No
Drer\LOC568792
2 of 14
Yes
No
Drer\LOC100001991
2 of 14
Yes
No
Drer\LOC100002059
2 of 14
Yes
No
Drer\adamts1
1 of 14
No
No
Drer\adamts5
1 of 14
No
No
Drer\adamts6
1 of 14
No
No
Drer\adamts7
1 of 14
No
No
Drer\adamts8a
1 of 14
No
No
Drer\adamts9
1 of 14
No
No
Drer\adamts13
1 of 14
No
No
Drer\adamtsl2
1 of 14
No
Yes
Drer\adamtsl3
1 of 14
No
No
Drer\adamtsl4
1 of 14
No
No
Drer\adamtsl5
1 of 14
No
No
Drer\adamtsl7
1 of 14
No
No
Drer\adgrb1a
1 of 14
No
No
Drer\col28a1a
1 of 14
No
No
Drer\paplna
1 of 14
No
No
Drer\paplnb
1 of 14
No
No
Drer\si:ch211-267e7.3
1 of 14
No
No
Drer\si:dkeyp-73b11.8
1 of 14
No
No
Drer\wfikkn2a
1 of 14
No
No
Drer\wfikkn2b
1 of 14
No
No
Drer\wu:fb59d01
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\mig-17
6 of 14
Yes
Yes
Cele\adt-1
2 of 14
No
No
Cele\adt-3
2 of 14
No
No
Cele\adt-2
1 of 14
No
No
Cele\gon-1
1 of 14
No
No
Cele\madd-4
1 of 14
No
No
Cele\mig-6
1 of 14
No
No
Cele\T21B6.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP011737
4 of 12
Yes
Yes
Agam\AgaP_AGAP001113
2 of 12
No
No
Agam\AgaP_AGAP001662
2 of 12
No
No
Agam\AgaP_AGAP004201
2 of 12
No
No
Agam\AgaP_AGAP004961
2 of 12
No
No
Agam\AgaP_AGAP000974
1 of 12
No
No
Agam\AgaP_AGAP003498
1 of 12
No
No
Agam\AgaP_AGAP007792
1 of 12
No
No
Agam\AgaP_AGAP010001
1 of 12
No
No
Agam\AgaP_AGAP010003
1 of 12
No
No
Agam\AgaP_AGAP013468
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:sona. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
AdamTS-A
3 of 13
AdamTS-B
3 of 13
Ppn
3 of 13
stl
3 of 13
nolo
2 of 13
CG31609
1 of 13
loh
1 of 13
Meltrin
1 of 13
mmd
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Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    sona - arr
    anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot
    (Han et al., 2020)
    sona - dlg1
    two hybrid
    (Kim et al., 2016)
    sona - wg
    anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, enzymatic study
    (Won et al., 2019, Kim et al., 2016)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    sona
    suppressible
    arr
    (Han et al., 2020)
    sona
    suppressible
    wg
    (Won et al., 2019)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    wg
    suppressible
    sona
    (Won et al., 2019)
    wls
    suppressible
    sona
    (Kim et al., 2016)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Positive Regulators of Wnt-TCF Signaling Pathway -
    Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-104
    Cytogenetic map
    59F7-60A1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    59F7-60A1
    Limits computationally determined from genome sequence between P{EP}eglEP938 and P{lacW}eIF6k13214
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-104

    (FlyBase, 2016)

    2-109.4

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (21)
    Genomic Clones (35)
    cDNA Clones (15)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Kim et al., 2016)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Overexpression of CG9850 inhibits cell growth, while loss of CG9850 causes overproliferation of cells.

          (Cho, 2005)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: CG11169 CG9850

          (Cho, 2005.3.2)
          Additional comments

          Annotations CG9850 and CG11169 merged as CG9850 in release 4.2 of the genome annotation.

          (FlyBase Genome Annotators, 2005)
          Nomenclature History
          Source for database identify of

          Source for identity of: sona CG9850

          (Kim et al., 2016)

          Source for identity of: CG9850 Dimp

          (Cho, 2005.6.23)
          Nomenclature comments
          Etymology

          Named 'sol narae' meaning 'small wing' in Korean, based on the small wing phenotype of mutant escapers.

          (Kim et al., 2016)
          Synonyms and Secondary IDs (8)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 57 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (55)