a component of the conserved THO/TREX (transcription/export) complex involved in processing of nascent RNAs and mRNA export from nucleus - splicing-independent loading on nascent RNA - piRNA biogenesis - male meiosis- regulation of p53 and PI3K/AKT signaling
Please see the JBrowse view of Dmel\thoc5 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the THO complex, composed of at least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7 (PubMed:15133499). Interacts with piwi; the interaction might be partly RNA-mediated (PubMed:28472469). Interacts with CG9890 (PubMed:30713769).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\thoc5 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\thoc5 in JBrowse2-105
2-109.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of thoc5 CG2980 was sequence comparison ( date:040503 ).
Source for identity of: thoc5 CG2980