FBXO7
Please see the JBrowse view of Dmel\ntc for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Genes with CDS overlap: ntc and CG32264 share promoter, first exon and N-terminal coding sequences (46 residues).
There is only one protein coding transcript and one polypeptide associated with this gene
Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, at least composed of ntc, skpA and Cul1. Interacts (via F-box domain) with skpA and Cul1. Interacts with Prosalpha7 and PI31. Interacts with Bruce.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ntc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
ntc protein acuumulates predominantly around the outer borders of the individualization complex.
JBrowse - Visual display of RNA-Seq signals
View Dmel\ntc in JBrowse3-9
3-8.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: ntc CG10855
The gene is named "nutcracker", for "novel ubiquitin targeting complex required for activating caspases".