required for assembly of smooth septate junctions (sSJs) together with mesh and Tsp2A - required for maintaining intestinal stem cell homeostasis through the regulation of aPKC and Yki activities in the Drosophila midgut - expressed in Malpighian tubule, embryonic/larval visceral muscle, gut section and primordial germ cells
Please see the JBrowse view of Dmel\Ssk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Forms a complex with Tsp2A and mesh (PubMed:26848177). Interacts with mesh; the interaction may be necessary for the localization of both proteins to the cell apicolateral region (PubMed:22854041).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ssk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Ssk is expressed in the midgut and Malpighian tubules but not in the foregut and hindgut from embryos to adults. It is localized to septate junctions.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ssk in JBrowse3-47
3-43.5
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Ssk CG6981
Named 'Snakeskin' because of its immunofluorescence staining pattern in the midgut.