FlyBase Gene Report: Dmel\CDase

General Information

Symbol

Dmel\CDase

Species

D. melanogaster

Name

Ceramidase

Annotation Symbol

CG1471

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039774

Gene Model Status

Current

Stock Availability

8 publicly available

Enzyme Name (EC)

ceramidase (3.5.1.23)

Gene Summary

Ceramidase (CDase) encodes a protein that has a cell non-autonomous function in maintaining membrane homeostasis. CDase targeted over-expression suppresses retinal degeneration in certain photoreceptor degeneration mutants. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

slab

Key Links

Genomic Location

Cytogenetic map

99F5-99F6

Sequence location

3R:30,459,521..30,465,736 [+]

Recombination map

3-100

RefSeq locus

NT_033777 REGION:30459521..30465736

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables N-acylsphingosine amidohydrolase activity

inferred from direct assay

(Acharya et al., 2008, Acharya et al., 2003)

inferred from direct assay

(Yoshimura et al., 2002)

inferred from mutant phenotype

(Yuan et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables N-acylsphingosine amidohydrolase activity

inferred from biological aspect of ancestor with PANTHER:PTN004377481

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR006823

(InterPro Project Members, 2004-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in ceramide catabolic process

inferred from direct assay

(Yoshimura et al., 2002)

involved_in chemical synaptic transmission

inferred from mutant phenotype

(Rohrbough et al., 2004)

involved_in hatching behavior

inferred from mutant phenotype

(Rohrbough et al., 2004)

involved_in photoreceptor cell maintenance

inferred from mutant phenotype

(Acharya et al., 2008)

involved_in sphingolipid metabolic process

inferred from direct assay

(Yoshimura et al., 2002)

involved_in synaptic vesicle exocytosis

inferred from mutant phenotype

(Rohrbough et al., 2004)

involved_in synaptic vesicle fusion to presynaptic active zone membrane

inferred from mutant phenotype

(Rohrbough et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in ceramide catabolic process

inferred from electronic annotation with InterPro:IPR006823

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN004377481

(GO Reference Genome Project, 2011-)

involved_in long-chain fatty acid biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN004377481

(GO Reference Genome Project, 2011-)

involved_in sphingosine biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN004377481

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Rohrbough et al., 2004)

located_in extracellular region

inferred from direct assay

(Yoshimura et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular region

inferred from biological aspect of ancestor with PANTHER:PTN004377481

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF LINEAR AMIDES

Protein Family (UniProt)

Belongs to the neutral ceramidase family. (Q9VA70)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

N-acylsphingosine amidohydrolase activity

an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine (3.5.1.23)

RHEA 20856:

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED CARBON-NITROGEN HYDROLASES OF LINEAR AMIDES -: This group comprises carbon-nitrogen hydrolases of linear amides that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition.

(UniProt, Q9VA70)

Summary (Interactive Fly)

enzyme that hydrolyzes ceramide to sphingosine, a critical structural components of cell membranes that act as second messengers in diverse signal transduction cascades - maintains photoreceptor homeostasis - regulates synaptic vesicle exocytosis and trafficking

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CDase for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VA70)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CDase-RA

FBtr0085646

NM_143540

2639

704

CDase-RB

FBtr0085645

NM_170488

2372

704

CDase-RC

FBtr0085647

NM_170489

2744

704

CDase-RD

FBtr0085648

NM_170490

2740

704

CDase-RE

FBtr0085649

NM_170491

2875

704

CDase-RF

FBtr0331357

NM_001276180

2336

704

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CDase-PA

FBpp0085008

78.2

704

6.57

FBpp0085007

78.2

704

6.57

FBpp0085009

78.2

704

6.57

FBpp0085010

78.2

704

6.57

FBpp0085011

78.2

704

6.57

FBpp0303775

78.2

704

6.57

Q9VA70

NP_001263109

AGB96488

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

704 aa isoforms: CDase-PA, CDase-PB, CDase-PC, CDase-PD, CDase-PE, CDase-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

N-glycosylated.

(UniProt, Q9VA70)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CDase using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.67

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10 -- 13

embryonic/larval hemocyte

(Herr and Harris, 2004)

embryonic stage 11 -- 12

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic precursor of adult hindgut

(Fisher et al., 2012)

embryonic stage 16

posterior midgut primordium

(Herr and Harris, 2004)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Rohrbough et al., 2004)

located_in extracellular region

inferred from direct assay

(Yoshimura et al., 2002)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CDase in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CDase

View exonic expression by tissue for Dmel\CDase

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039774

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43618/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039774

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039774

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039774

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1471

Flygut - An atlas of the Drosophila adult midgut

FBgn0039774

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CDase

Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CDase

Transgenic constructs containing regulatory region of CDase

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3R)slab-3

(Rohrbough et al., 2004)

Df(3R)tll-g

(Rohrbough et al., 2004)

Gene not disrupted in

Df(3R)20

(Rohrbough et al., 2004)

Df(3R)L127

(Rohrbough et al., 2004)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

CDase¹

lethal - all die during embryonic stage

lethal - all die during embryonic stage (with CDase^slab-1)

CDase^slab-2

lethal - all die during embryonic stage (with CDase^slab-2)

CDase^slab-1

lethal - all die during embryonic stage (with Df(3R)slab-3)

lethal - all die during embryonic stage | recessive

CDase¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CDase^GD3129

viable, with Scer\GAL4^Mef2.PR

CDase^GD3129

viable, with Scer\GAL4^pnr-MD237

CDase^GD3129

viable, with Scer\GAL4^tin.CΔ4

CDase^GD3129

Other Phenotypes

Allele

abnormal locomotor behavior | recessive

CDase^slab-1

abnormal neurophysiology

CDase¹

abnormal neurophysiology (with CDase^slab-1)

CDase^slab-2

abnormal neurophysiology (with CDase^slab-2)

CDase^slab-1

abnormal neurophysiology (with Df(3R)slab-3)

CDase^slab-1

abnormal neurophysiology | recessive

CDase^slab-1

increased cell death

CDase¹

some die during embryonic stage

some die during embryonic stage (with CDase^slab-1)

CDase^slab-2

some die during embryonic stage (with CDase^slab-2)

CDase^slab-1

some die during embryonic stage (with Df(3R)slab-3)

some die during embryonic stage | recessive

CDase¹

Phenotype manifest in

Allele

eye disc

CDase¹

eye photoreceptor cell

CDase¹

rhabdomere

CDase¹

synaptic vesicle

CDase^slab-1

synaptic vesicle (with CDase^slab-1)

CDase^slab-2

synaptic vesicle (with CDase^slab-2)

CDase^slab-1

synaptic vesicle (with Df(3R)slab-3)

CDase^slab-1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\ASAH2

13 of 14

Yes

Hsap\ASAH2B

6 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Asah2

14 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Asah2

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\asah2

11 of 13

Yes

Xtro\LOC100494440

2 of 13

Yes

Xtro\rbp5

1 of 13

Danio rerio (Zebrafish) (1)

Drer\asah2

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP000973

12 of 12

Yes

Agam\AgaP_AGAP003730

12 of 12

Yes

Agam\AgaP_AGAP012841

4 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\AT2G38010

13 of 13

Yes

Atha\AT1G07380

12 of 13

Yes

Atha\AT5G58980

12 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CDase. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

lipotoxic cardiomyopathy, ceramide/sphingolipid-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

CDase^GD3129

model of cardiomyopathy

CEA

(Walls et al., 2018)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

CDase^UAS.cAa

ameliorates retinal disease

modeled by norpA^P41

(Acharya et al., 2003)

exacerbates primary autosomal dominant microcephaly 18

modeled by bchs⁵⁸

(Hebbar et al., 2015)

CDase^slab-2

ameliorates primary autosomal dominant microcephaly 18

modeled by bchs⁵⁸

(Hebbar et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ASAH2; N-acylsphingosine amidohydrolase 2

13 of 14

611202

ASAH2B; N-acylsphingosine amidohydrolase 2B

6 of 14

610987

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CDase

suppressible

bwa

(Yuan et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Arr2

suppressible

CDase

(Acharya et al., 2008, Acharya et al., 2003)

bchs

suppressible

CDase

(Hebbar et al., 2015)

bchs

enhanceable

CDase

(Hebbar et al., 2015)

Cerk

suppressible

CDase

(Dasgupta et al., 2009)

ninaE

enhanceable

CDase

(Acharya et al., 2004)

norpA

suppressible

CDase

(Acharya et al., 2003)

shi

suppressible

CDase

(Acharya et al., 2003)

spin

enhanceable

CDase

(Hebbar et al., 2017)

spin

suppressible

CDase

(Hebbar et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68472

DroID - A comprehensive database of gene and protein interactions.

FBgn0039774

MIST (genetic) - An integrated Molecular Interaction Database

43618

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Glycosphingolipid catabolism

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Glycosphingolipid catabolism

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-100

Cytogenetic map

99F5-99F6

Sequence location

3R:30,459,521..30,465,736 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99F5-99F6

Limits computationally determined from genome sequence between P{PZ}ncd⁰⁵⁸⁸⁴ and P{lacW}l(3)s2500^s2500

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-100

(FlyBase, 2016)

3-98.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

23627

w¹¹¹⁸; Mi{ET1}CDase^MB03531/TM6C, Sb¹

92701

y¹ w^*; TI{CRIMIC.TG4.0}CDase^{CR70089-TG4.0}

44356

y¹ w^*; Mi{MIC}CDase^MI08043/TM3, Sb¹ Ser¹

59678

y¹ w^*; Mi{MIC}CDase^MI14197/TM3, Sb¹ Ser¹

36764

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03025}attP2/TM3, Sb¹

NIG-Fly

HMS03025

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03025}attP2/TM3, Sb¹

VDRC

v110671

P{KK100757}VIE-260B

v30189

w¹¹¹⁸; P{GD3129}v30189

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (53)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD07768

Other clones

FI23007

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039774

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039774

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila EST AA699045 (inverted).

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: CDase anon-WO0118547.407

(FlyBase, 1996-)

Additional comments

Source for merge of CDase anon-WO0118547.407 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: CDase CG1471

(Acharya, 2003.3.31)

Nomenclature comments

Etymology

The name "slug-a-bed" refers to the characteristic arrest of partially hatched mutant embryos, thus appearing disinclined to start moving.

(Rohrbough et al., 2004)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CDase

(Vesala et al., 2024, Li et al., 2022, Mu et al., 2019, Gene Disruption Project members, 2018-, Huang et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Yuan et al., 2011, Dasgupta et al., 2009, Acharya et al., 2008, Zhang et al., 2007, Rehwinkel et al., 2004, Yoshimura et al., 2002)

CG1471

(Hebbar et al., 2015, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Weber et al., 2008, Rohrbough et al., 2004, Giot et al., 2003, Renault et al., 2002, Renault et al., 2002, Zinke et al., 2002)

Cdase

(Walls et al., 2018, Hebbar et al., 2015)

anon-WO0118547.407

cdase

(Rahman et al., 2014, Yuan et al., 2011, Kuronen et al., 2009, Acharya et al., 2008)

fcd

(Yoshimura, 2003.6.11)

slab

(Hebbar et al., 2017, Hebbar et al., 2015, Rohrbough et al., 2004)

Name Synonyms

Ceramidase

(Hebbar et al., 2015, Kuronen et al., 2009, Acharya et al., 2008, Acharya et al., 2004)

ceramidase

(Acharya et al., 2003, Yoshimura et al., 2002)

slug-a-bed

(Rohrbough et al., 2004)

Secondary FlyBase IDs

FBgn0062033

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 67 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43618

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VA70

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VA70

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A4V3N7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VA70

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039774

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43618/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039774

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039774

FlyMine - An integrated database for Drosophila genomics

FBgn0039774

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1471

MARRVEL_MODEL - MARRVEL (model organism gene)

43618

Linkouts

BioGRID - A database of protein and genetic interactions.

68472

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039774

DroID - A comprehensive database of gene and protein interactions.

FBgn0039774

DRSC - Results frm RNAi screens

FBgn0039774

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039774

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039774

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1471

Flygut - An atlas of the Drosophila adult midgut

FBgn0039774

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039774

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

43618

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Glycosphingolipid catabolism

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Glycosphingolipid catabolism

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

-0.67

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