awol, absent without leave
a conserved regulator of cell cycle, co-ordination of centrosome and nuclear division cycles, and maintenance of chromosome condensation
Please see the JBrowse view of Dmel\MCPH1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MCPH1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
RT-PCR experiments show that MCPH1 transcripts are present at all developmental stages. Highest embryonic levels of MCPH1 transcripts are seen in syncytial stage embryos, distributed throughout the embryo. The different isoforms were assayed by RT-PCR. Both splice and unspliced forms (intron 7) are found in embryos but only the spliced form is observed in testis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\MCPH1 in JBrowse2-65
2-66.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New annotation (CG30038) in release 3 of the genome annotation.
Source for merge of: MCPH1 CG30038
Source for merge of: MCPH1 awol
Source for merge of: CG13184 CG8981
Annotations CG8981 and CG30038 merged as CG42572 in release 5.16 of the genome annotation.
Source for merge of CG13184 CG8981 was a shared cDNA ( date:010720 ).
Source for identity of: MCPH1 CG8981
The gene is named "absent without leave" based on the mutant phenotype of acentrosomal mitotic spindles.